HDL Stimulation of Endothelial Nitric Oxide Synthase A Novel Mechanism of HDL Action

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

1999 • 3,529 citations

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

1999 • 2,577 citations

High-Density Lipoprotein — The Clinical Implications of Recent Studies

1989 • 1,565 citations

Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI

1991 • 990 citations

Estrogen receptor α mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen

1999 • 895 citations

AMP‐activated protein kinase phosphorylation of endothelial NO synthase

1999 • 827 citations

Acylation Targets Endothelial Nitric-oxide Synthase to Plasmalemmal Caveolae

1996 • 798 citations

High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase

2001 • 712 citations

Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling.

1996 • 677 citations

Coordinated Control of Endothelial Nitric-oxide Synthase Phosphorylation by Protein Kinase C and the cAMP-dependent Protein Kinase

2001 • 547 citations

Regulation of Endothelial Nitric Oxide Synthase: Location, Location, Location

2002 • 542 citations

Endothelial Nitric Oxide Synthase Is Regulated by Tyrosine Phosphorylation and Interacts with Caveolin-1

1996 • 532 citations

Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits.

1994 • 501 citations

Phosphorylation of Endothelial Nitric Oxide Synthase in Response to Fluid Shear Stress

1996 • 497 citations

Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology

1999 • 496 citations

Loss of SR-BI Expression Leads to the Early Onset of Occlusive Atherosclerotic Coronary Artery Disease, Spontaneous Myocardial Infarctions, Severe Cardiac Dysfunction, and Premature Death in Apolipoprotein E–Deficient Mice

2002 • 478 citations

The Akt kinase signals directly to endothelial nitric oxide synthase

1999 • 469 citations

Shear Stress Stimulates Phosphorylation of Endothelial Nitric-oxide Synthase at Ser1179 by Akt-independent Mechanisms

2002 • 441 citations

Murine SR-BI, a High Density Lipoprotein Receptor That Mediates Selective Lipid Uptake, Is N-Glycosylated and Fatty Acylated and Colocalizes with Plasma Membrane Caveolae

1997 • 375 citations

High Density Lipoprotein-induced Endothelial Nitric-oxide Synthase Activation Is Mediated by Akt and MAP Kinases

2003 • 373 citations

Reciprocal Phosphorylation and Regulation of Endothelial Nitric-oxide Synthase in Response to Bradykinin Stimulation

2001 • 368 citations

Oxidized Low Density Lipoprotein Displaces Endothelial Nitric-oxide Synthase (eNOS) from Plasmalemmal Caveolae and Impairs eNOS Activation

1999 • 357 citations

Atherosclerosis in Transgenic Mice Overexpressing Apolipoprotein A-II

1993 • 355 citations

Identification of Flow-dependent Endothelial Nitric-oxide Synthase Phosphorylation Sites by Mass Spectrometry and Regulation of Phosphorylation and Nitric Oxide Production by the Phosphatidylinositol 3-Kinase Inhibitor LY294002

1999 • 331 citations

Gene Transfer and Hepatic Overexpression of the HDL Receptor SR-BI Reduces Atherosclerosis in the Cholesterol-Fed LDL Receptor–Deficient Mouse

2000 • 330 citations

Phosphorylation and subcellular translocation of endothelial nitric oxide synthase.

1993 • 329 citations

Atheroprotective mechanisms of HDL

1999 • 324 citations

Decreased Atherosclerosis in Heterozygous Low Density Lipoprotein Receptor-deficient Mice Expressing the Scavenger Receptor BI Transgene

1999 • 313 citations

High Density Lipoprotein Prevents Oxidized Low Density Lipoprotein-induced Inhibition of Endothelial Nitric-oxide Synthase Localization and Activation in Caveolae

2000 • 308 citations

Intracellular pH and Tyrosine Phosphorylation but Not Calcium Determine Shear Stress–Induced Nitric Oxide Production in Native Endothelial Cells

1996 • 287 citations

Endothelial Nitric-oxide Synthase (Type III) Is Activated and Becomes Calcium Independent upon Phosphorylation by Cyclic Nucleotide-dependent Protein Kinases

2000 • 279 citations

Protein composition determines the anti-atherogenic properties of HDL in transgenic mice

1993 • 276 citations

Liver-specific Overexpression of Scavenger Receptor BI Decreases Levels of Very Low Density Lipoprotein ApoB, Low Density Lipoprotein ApoB, and High Density Lipoprotein in Transgenic Mice

1998 • 271 citations

Long-term inhibition of NO synthesis promotes atherosclerosis in the hypercholesterolemic rabbit thoracic aorta. PGH2 does not contribute to impaired endothelium-dependent relaxation.

1994 • 255 citations

Apolipoproteins of HDL can directly mediate binding to the scavenger receptor SR-BI, an HDL receptor that mediates selective lipid uptake

1997 • 218 citations

The role of the high-density lipoprotein receptor SR-BI in cholesterol metabolism

2000 • 203 citations

High density lipoprotein receptors, binding proteins, and ligands

1999 • 203 citations

Increased LDL Cholesterol and Atherosclerosis in LDL Receptor–Deficient Mice With Attenuated Expression of Scavenger Receptor B1

2000 • 170 citations

Decreased basal nitric oxide release in hypercholesterolemia increases neutrophil adherence to rabbit coronary artery endothelium.

1993 • 155 citations

Binding of High Density Lipoprotein (HDL) and Discoidal Reconstituted HDL to the HDL Receptor Scavenger Receptor Class B Type I

2000 • 153 citations

Binding and Cross-linking Studies Show That Scavenger Receptor BI Interacts with Multiple Sites in Apolipoprotein A-I and Identify the Class A Amphipathic α-Helix as a Recognition Motif

2000 • 116 citations

Centripetal cholesterol flux to the liver is dictated by events in the peripheral organs and not by the plasma high density lipoprotein or apolipoprotein A-I concentration

1998 • 110 citations

Inhibition of Protein Kinase Cα Prevents Endothelial Cell Migration and Vascular Tube Formation In Vitro and Myocardial Neovascularization In Vivo

2002 • 85 citations

Influence of Caveolin, Cholesterol, and Lipoproteins on Nitric Oxide Synthase Implications for Vascular Disease

2001 • 80 citations

Decreased Susceptibility to Diet-Induced Atherosclerosis in Human Apolipoprotein A-II Transgenic Mice

2000 • 60 citations

Mechanical endothelial damage results in basic fibroblast growth factor–mediated activation of extracellular signal-regulated kinases

1999 • 37 citations

Lipoprotein classes and coronary disease regression

1998 • 23 citations

Deleted Work

1955 • 0 citations