A Novel Cytochrome P450 Expressed Primarily in Brain

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

Genomic sequencing.

1984 • 8,343 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

Place navigation impaired in rats with hippocampal lesions

1982 • 6,277 citations

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

1987 • 5,139 citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1986 • 3,586 citations

Molecular Genetics of Human Color Vision: The Genes Encoding Blue, Green, and Red Pigments

1986 • 1,702 citations

The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature

1993 • 1,663 citations

Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme

1989 • 1,244 citations

Adrenal steroid receptors and actions in the nervous system

1986 • 1,231 citations

Structure-activity relationships for steroid interaction with the gamma-aminobutyric acidA receptor complex.

1987 • 601 citations

Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor.

1991 • 521 citations

Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues.

1987 • 449 citations

Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact.

1988 • 444 citations

Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it.

1992 • 442 citations

Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).

1989 • 440 citations

Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus.

1995 • 426 citations

Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain

1993 • 402 citations

Characterization of Two Genes Encoding Human Steroid 11β-Hydroxylase (P-45011β)

1989 • 377 citations

Neurosteroids: Biosynthesis of Pregnenolone and Progesterone in Primary Cultures of Rat Glial Cells*

1989 • 372 citations

Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis.

1990 • 365 citations

On the membrane topology of vertebrate cytochrome P-450 proteins.

1988 • 362 citations

Progesterone receptor-mediated effects of neuroactive steroids

1993 • 297 citations

Neurosteroids: a new function in the brain

1991 • 296 citations

Cytochrome P450 and the arachidonate cascade ¹

1992 • 288 citations

The role of individual human cytochrpmes P450 in drug metabolism and clinical response

1992 • 246 citations

Dehydroepiandrosterone and its sulfate enhance memory retention in mice

1988 • 232 citations

Pregnenolone sulfate potentiation of N-methyl-D-aspartate receptor channels in hippocampal neurons.

1993 • 223 citations

Bovine adrenocortical cytochrome P-450(17 alpha). Regulation of gene expression by ACTH and elucidation of primary sequence.

1986 • 211 citations

S26 ribosomal protein RNA: an invariant control for gene regulation experiments in eucaryotic cells and tissues

1993 • 198 citations

Gene Structure of Human Cytochrome P-450(SCC), Cholesterol Desmolase

1987 • 192 citations

Regional Distribution of Cytochrome P‐450 in the Rat Brain: Spectral Quantitation and Contribution of P‐450b,e and P‐450c,d

1988 • 147 citations

Effect of ethanol on cytochrome P450 in the rat brain.

1994 • 123 citations

Subcellular distribution of cytochrome P-450 in the brain

1986 • 116 citations

Molecular cloning and sequence analysis of cDNA encoding human cholesterol 7α‐hydroxylase

1990 • 114 citations

Cloning of the human cholesterol 7α-hydroxylase gene (CYP7) and localization to chromosome 8q11–q12

1992 • 106 citations

Molecular cloning of cDNA for cholesterol 7α‐hydroxylase from rat liver microsomes

1989 • 105 citations

Structure of a bovine gene for P-450c21 (steroid 21-hydroxylase) defines a novel cytochrome P-450 gene family.

1986 • 96 citations

The pharmacology of neurosteroidogenesis

1994 • 95 citations

Immunohistochemical localization of cytochrome P-450 in rat brain

1987 • 87 citations

Steroid hormones are multifunctional messengers to the brain

1991 • 85 citations

Extraadrenal Formation of a Mineralocorticosteroid: Deoxycorticosterone and Deoxycorticosterone Sulfate Biosynthesis and Metabolism*

1982 • 83 citations

Point mutations at threonine-301 modify substrate specificity of rabbit liver microsomal cytochromes P-450 (laurate (ω-1)-hydroxylase and testosterone 16α-hydroxylase)

1989 • 72 citations

Modulation of the GABA_A receptor complex by steroids in slices of rat cuneate nucleus

1989 • 71 citations

Rip locus: regulation of female-specific isozyme (I-P-45016.alpha.) of testosterone 16.alpha.-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA

1988 • 60 citations

Cytochrome P450: molecular architecture, mechanism, and prospects for rational inhibitor design.

1988 • 55 citations

Cytochrome P450s of the 4A Subfamily in the Brain

1994 • 36 citations

Regulation of cytochrome P450 in the central nervous system

1993 • 34 citations

Purification of Multiple Forms of Cytochrome P450 from a Human Brain and Reconstitution of Catalytic Activities

1993 • 34 citations

Effects of adrenocortical steroids on long-term potentiation in the limbic system: Basic mechanisms and behavioral consequences

1993 • 33 citations

Modulation by adrenal steroids of limbic function

1991 • 28 citations

Growth Hormone-Dependent and -Independent Regulation of Cytochrome P-450 Isozyme Expression in Streptozotocin-Diabetic Rats*

1991 • 25 citations

Species differences of testosterone 16-hydroxylases in liver microsomes of guinea pig, rat and dog

1993 • 24 citations

Sex-specific isozymes of P-450

1987 • 11 citations