Identification of a Potential Effector Pathway for the Trimeric Go Protein Associated with Secretory Granules

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

1996 • 1,045 citations

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.

1996 • 872 citations

Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity.

1990 • 600 citations

Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes.

1996 • 560 citations

Multiple calcium-dependent processes related to secretion in bovine chromaffin cells

1993 • 524 citations

Phosphoinositides and Calcium as Regulators of Cellular Actin Assembly and Disassembly

1994 • 524 citations

ATP-dependent inositide phosphorylation required for Ca2+-activated secretion

1995 • 508 citations

Role of Rho in Chemoattractant-Activated Leukocyte Adhesion Through Integrins

1996 • 494 citations

Gα12 and Gα13 Stimulate Rho-dependent Stress Fiber Formation and Focal Adhesion Assembly

1995 • 443 citations

Identification of a Putative Target for Rho as the Serine-Threonine Kinase Protein Kinase N

1996 • 417 citations

Rho as a regulator of the cytoskeleton

1995 • 386 citations

Protein Kinase N (PKN) and PKN-Related Protein Rhophilin as Targets of Small GTPase Rho

1996 • 384 citations

Phosphatidylinositol transfer protein required for ATP-dependent priming of Ca2+-activated secretion

1993 • 346 citations

Chromaffin cell cortical actin network dynamics control the size of the release-ready vesicle pool and the initial rate of exocytosis

1995 • 341 citations

ERM proteins: head-to-tail regulation of actin-plasma membrane interaction

1997 • 312 citations

Rho- and Rac-dependent Assembly of Focal Adhesion Complexes and Actin Filaments in Permeabilized Fibroblasts: An Essential Role for Ezrin/Radixin/Moesin Proteins

1997 • 303 citations

Functional modification of a 21-kilodalton G protein when ADP-ribosylated by exoenzyme C3 of Clostridium botulinum.

1988 • 299 citations

Resolution of regulated secretion into sequential MgATP-dependent and calcium-dependent stages mediated by distinct cytosolic proteins.

1992 • 286 citations

Rho: a connection between membrane receptor signalling and the cytoskeleton

1996 • 271 citations

Rho family GTPases: the cytoskeleton and beyond

1996 • 262 citations

Releasable pools and the kinetics of exocytosis in adrenal chromaffin cells

1994 • 254 citations

The rho gene product expressed in E. Coli is a substrate of botulinum ADP-ribosyltransferase C3

1989 • 252 citations

Activation of Exocytosis by the Heterotrimeric G Protein G _i3

1993 • 233 citations

Evidence that the inositol phospholipids are necessary for exocytosis. Loss of inositol phospholipids and inhibition of secretion in permeabilized cells caused by a bacterial phospholipase C and removal of ATP

1990 • 227 citations

Rho Is Required for Gαq and α1-Adrenergic Receptor Signaling in Cardiomyocytes

1996 • 220 citations

The GTPase Rab3a negatively controls calcium-dependent exocytosis in neuroendocrine cells.

1994 • 213 citations

Kinetic analysis of secretion from permeabilized adrenal chromaffin cells reveals distinct components.

1992 • 208 citations

Inhibition of RabSB expression attenuates Ca2+-dependent exocytosis in rat anterior pituitary cells

1993 • 199 citations

Association of the GTP-binding protein Rab3A with bovine adrenal chromaffin granules.

1990 • 195 citations

Chromaffin granule-associated phosphatidylinositol 4-kinase activity is required for stimulated secretion.

1996 • 177 citations

Characterization of Clostridium perfringens iota-toxin genes and expression in Escherichia coli

1993 • 174 citations

Regulated Exocytosis in Chromaffin Cells

1998 • 165 citations

Chromaffin granule-associated phosphatidylinositol 4-kinase activity is required for stimulated secretion.

1996 • 163 citations

Identification and quantification of polyphosphoinositides produced in response to platelet-derived growth factor stimulation

1991 • 149 citations

Regulated Exocytosis in Chromaffin Cells

1997 • 148 citations

Mastoparan interacts with the carboxyl terminus of the alpha subunit of Gi.

1990 • 138 citations

Peripheral actin filaments control calcium-mediated catecholamine release from streptolysin-O-permeabilized chromaffin cells.

1988 • 137 citations

Actin filament organization in activated mast cells is regulated by heterotrimeric and small GTP-binding proteins.

1994 • 135 citations

The small GTP-binding proteins, Rac and Rho, regulate cytoskeletal organization and exocytosis in mast cells by parallel pathways.

1996 • 130 citations

Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits.

1995 • 130 citations

Exocytosis in chromaffin cells. Possible involvement of the heterotrimeric GTP-binding protein G(o)

1993 • 122 citations

Chromogranin A in the pancreatic islet: cellular and subcellular distribution.

1986 • 115 citations

The Heterotrimeric G-protein Gi Is Localized to the Insulin Secretory Granules of β-Cells and Is Involved in Insulin Exocytosis

1995 • 113 citations

The control of cytoskeletal actin and exocytosis in intact and permeabilized adrenal chromaffin cells: role of calcium and protein kinase C

1989 • 104 citations

Recombinant Scinderin Enhances Exocytosis, an Effect Blocked by Two Scinderin-Derived Actin-Binding Peptides and PIP2

1996 • 80 citations

Secretory cell actin-binding proteins: identification of a gelsolin-like protein in chromaffin cells.

1986 • 75 citations

Detection of G-protein heterotrimers on large dense core and small synaptic vesicles of neuroendocrine and neuronal cells.

1994 • 73 citations

Trimeric G Proteins Control Exocytosis in Chromaffin Cells

1997 • 64 citations

Low molecular weight GTP-binding proteins in human neutrophil granule membranes.

1991 • 62 citations

Ca2+ and pH determine the interaction of chromaffin cell scinderin with phosphatidylserine and phosphatidylinositol 4,5,-biphosphate and its cellular distribution during nicotinic-receptor stimulation and protein kinase C activation.

1992 • 61 citations

Purification and identification of FOAD-II, a cytosolic protein that regulates secretion in streptolysin-O permeabilized mast cells, as a rac/rhoGDI complex.

1996 • 58 citations

Screening of phosphatidylinositol kinase inhibitors from Streptomyces.

1989 • 58 citations

Involvement of Rho and Rac small G proteins and Rho GDI in Ca²⁺‐dependent exocytosis from PC12 cells

1996 • 50 citations

GAP-43 controls the availability of secretory chromaffin granules for regulated exocytosis by stimulating a granule-associated G0.

1994 • 48 citations

Rho guanine nucleotide dissociation inhibitor protein (RhoGDI) inhibits exocytosis in mast cells.

1996 • 47 citations

Trimeric G Proteins Control Regulated Exocytosis in Bovine Chromaffin Cells: Sequential Involvement of Go Associated With Secretory Granules and Gi₃ Bound to the Plasma Membrane

1996 • 46 citations

The amino-terminal 200 amino acids of the plasma membrane Na+,K+-ATPase alpha subunit confer ouabain sensitivity on the sarcoplasmic reticulum Ca(2+)-ATPase.

1993 • 36 citations

Exocytosis in chromaffin cells: evidence for a MgATP-independent step that requires a pertussis toxin-sensitive GTP-binding protein

1994 • 36 citations

Phosphatidylinositol kinase of bovine adrenal chromaffin granules: Kinetic properties and inhibition by low concentrations of Ca2+

1988 • 34 citations

Rho proteins are localized with different membrane compartments involved in vesicular trafficking in anterior pituitary cells

1996 • 30 citations

Inhibition of adrenal dopamine-β-hydroxylase by 6-hydroxy dopamine

1973 • 24 citations

Exocytosis in single chromaffin cells: regulation by a secretory granule-associated Go protein.

1997 • 17 citations

Brefeldin A and a synthetic peptide to ADP-ribosylation factor (ARF) inhibit regulated exocytosis in melanotrophs

1995 • 14 citations