Regulation of cytoskeletal functions by Rho small GTP-binding proteins in normal and cancer cells

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.

1992 • 1,330 citations

FUNCTION AND REGULATION OF RAS

1993 • 1,161 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

On the Crawling of Animal Cells

1993 • 1,020 citations

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1991 • 961 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

PROTEIN ISOPRENYLATION AND METHYLATION AT CARBOXYL-TERMINAL CYSTEINE RESIDUES

1992 • 885 citations

The Cellular Functions of Small GTP-Binding Proteins

1990 • 881 citations

Small GTP-Binding Proteins and the Regulation of the Actin Cytoskeleton

1994 • 822 citations

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

1993 • 760 citations

Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

1995 • 665 citations

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1994 • 647 citations

rac, a novel ras-related family of proteins that are botulinum toxin substrates

1989 • 585 citations

Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity.

1990 • 560 citations

Asparagine residue in the rho Gene Product Is the Modification Site for Botulinum ADP-ribosyltransferase

1989 • 550 citations

Small GTP-Binding Proteins

1992 • 526 citations

Bcr encodes a GTPase-activating protein for p21rac

1991 • 474 citations

Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase.

1994 • 469 citations

Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction.

1992 • 458 citations

Post-translational modifications of p21rho proteins.

1992 • 422 citations

Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42.

1995 • 386 citations

Intracellular localization of the P21rho proteins.

1992 • 382 citations

Small GTP-binding proteins in vesicular transport

1990 • 381 citations

Regulation of cytoplasmic division of Xenopus embryo by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI).

1993 • 363 citations

Bridging Ral GTPase to Rho Pathways

1995 • 330 citations

Association between GTPase activators for Rho and Ras families

1992 • 322 citations

Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product.

1994 • 314 citations

Isolation and characterization of the faciogenital dysplasia (Aarskog-Scott syndrome) gene: A putative RhoRac guanine nucleotide exchange factor

1994 • 297 citations

Oncogene ect2 is related to regulators of small GTP-binding proteins

1993 • 281 citations

Microfilament Structure and Function in the Cortical Cytoskeleton

1991 • 276 citations

Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap.

1994 • 270 citations

Activation of rat liver phospholipase D by the small GTP-binding protein RhoA

1994 • 265 citations

Critical role of Rho in cell transformation by oncogenic Ras.

1995 • 256 citations

Development of cell polarity in budding yeast

1991 • 252 citations

Regulation and function of the Rho subfamily of small GTPases

1994 • 233 citations

A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways.

1994 • 195 citations

Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes.

1993 • 192 citations

Purification of the major GTP-binding proteins from human placental membranes.

1986 • 190 citations

Involvement of microtubule motors in basolateral and apical transport in kidney cells

1994 • 183 citations

A novel type of myosin implicated in signalling by rho family GTPases.

1995 • 176 citations

A putative effector of Ral has homology to Rho/Rac GTPase activating proteins.

1995 • 176 citations

Membrane-cytoskeleton interactions in animal cells

1989 • 157 citations

Direct Involvement of the Small GTP-binding Protein Rho in lbc Oncogene Function

1995 • 156 citations

The cytoplasmic domain of adherens‐type junctions

1991 • 151 citations

The Ras-related Small GTP-binding Protein RhoB Is Immediate-early Inducible by DNA Damaging Treatments

1995 • 149 citations

The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav.

1994 • 140 citations

Botulinum ADP-ribosyltransferase C3: a new tool to study low molecular weight GTP-binding proteins

1989 • 137 citations

The small GTPases Rac and Rho as regulators of secretion in mast cells

1995 • 137 citations

Membrane-binding domain of the small G protein G25K contains an S-(all-trans-geranylgeranyl)cysteine methyl ester at its carboxyl terminus.

1991 • 118 citations

Both stimulatory and inhibitory exchange proteins, smg GDS and rho GDI, are active on multiple small GTP-binding proteins

1992 • 116 citations

The ras-related gene rhoB is an immediate-early gene inducible by v-Fps, epidermal growth factor, and platelet-derived growth factor in rat fibroblasts.

1991 • 115 citations

Ash/Grb-2, a SH2/SH3-containing protein, couples to signaling for mitogenesis and cytoskeletal reorganization by EGF and PDGF.

1993 • 108 citations

Characterization and expression of the human rhoH12 gene product.

1989 • 108 citations

Tumorigenic activity of rho genes from Aplysia californica.

1993 • 108 citations

The epidermal growth factor receptor is associated with actin filaments

1992 • 101 citations

Regulation of Ras-related RhoB protein expression during the cell cycle.

1995 • 84 citations

Guanosine 5′-3-O-(Thio)triphosphate Stimulates Tyrosine Phosphorylation of p125FAK and Paxillin in Permeabilized Swiss 3T3 Cells

1995 • 72 citations

Identification and purification from bovine brain of a guanine-nucleotide-binding protein distinct from Gs, Gi and Go

1987 • 69 citations

Signal transduction through the GTP-binding proteins Rac and Rho

1994 • 65 citations

Isoprenoid modification of G25K (Gp), a low molecular mass GTP-binding protein distinct from p21ras.

1990 • 61 citations

Characterization of G25K, a GTP-binding protein containing a novel putative nucleotide binding domain

1989 • 59 citations

A hemopoietic specific gene encoding a small GTP binding protein is overexpressed during T cell activation

1991 • 50 citations

GTP-stimulated carboxyl methylation of a soluble form of the GTP-binding protein G25K in brain.

1992 • 41 citations

rho Gene amplification and malignant transformation

1990 • 16 citations

Cytosolic proteins of 21–23 kDa are methylated by kidney cortex membrane-associated C-terminal carboxyl methyltransferases

1994 • 12 citations

Low Molecular Weight GTP-Binding Proteins

1996 • 2 citations

Cellular Transformation and

1994 • 1 citations