Prevalence of methylenetetrahydrofolate reductase mutations in patients with venous thrombosis

A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease

1995 • 3,645 citations

Prevention of neural tube defects: Results of the Medical Research Council vitamin study

1992 • 2,294 citations

Hyperhomocysteinemia: An Independent Risk Factor for Vascular Disease

1991 • 2,191 citations

Plasma Homocysteine as a Risk Factor for Vascular Disease

1997 • 1,770 citations

Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group.

1991 • 1,717 citations

A Second Common Mutation in the Methylenetetrahydrofolate Reductase Gene: An Additional Risk Factor for Neural-Tube Defects?

1998 • 1,569 citations

Relation Between Folate Status, a Common Mutation in Methylenetetrahydrofolate Reductase, and Plasma Homocysteine Concentrations

1996 • 1,423 citations

A Second Genetic Polymorphism in Methylenetetrahydrofolate Reductase (MTHFR) Associated with Decreased Enzyme Activity

1998 • 1,283 citations

Hyperhomocysteinemia as a Risk Factor for Deep-Vein Thrombosis

1996 • 1,034 citations

Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida

1995 • 870 citations

Homocysteine metabolism in pregnancies complicated by neural-tube defects

1995 • 641 citations

Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells

1990 • 392 citations

Activation of endogenous factor V by a homocysteine-induced vascular endothelial cell activator.

1986 • 390 citations

Is hyperhomocysteinaemia a risk factor for recurrent venous thrombosis?

1995 • 374 citations

Hyperhomocysteinemia: a risk factor in women with unexplained recurrent early pregnancy loss

1993 • 294 citations

Elevated homocyst(e)ine levels with preeclampsia

1997 • 193 citations

Thermolabile Methylenetetrahydrofolate Reductase and Factor V Leiden in the Risk of Deep-Vein Thrombosis

1998 • 160 citations

The Methylenetetrahydrofolate Reductase TT677 Genotype Is Associated with Venous Thrombosis Independently of the Coexistence of the FV Leiden and the Prothrombin

1998 • 141 citations

Clinical chemistry and molecular biology of homocysteine metabolism: An update

1997 • 135 citations

Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida [short report]

1995 • 93 citations

Oral Contraceptives and Thrombotic Disease: Risk of Venous Thromboembolism

1997 • 88 citations

Hyperhomocyst(e)inemia and Atherothrombosis^a

1997 • 87 citations

High frequency (71%) of cystathionine β-synthase mutation G307S in Irish homocystinuria patients

1995 • 80 citations

Clinical Hematology: Principles, Procedures, Correlations

1992 • 73 citations

C677T substitution in the methylenetetrahydrofolate reductase gene as a risk factor for venous thrombosis and arterial disease in selected patients.

1999 • 69 citations

Mutated 5,10-methylenetetrahydrofolate reductase and moderate hyperhomocysteinaemia

1998 • 41 citations

Hyperhomocysteinemia and venous thromboembolic disease.

1997 • 38 citations

The inherited basis of venous thrombosis

1997 • 32 citations

Risk of venous thrombosis in carriers of a common mutation in the homocysteine regulatory enzyme methylenetetrahydrofolate reductase*

1997 • 21 citations

Genetic determinants of heritable venous thrombosis: genotyping methods for factor VLEIDEN A1691G, methylenetetrahydrofolate reductase C677T, prothrombin G20210A mutation, and algorithms for venous thrombosis investigations

1999 • 13 citations

Non-fasting reference intervals for the Abbott IMx^TM homocysteine and AxSYM^TM plasma folate assays: influence of the methylenetetrahydrofolate reductase 677 C→T mutation on homocysteine

2000 • 9 citations