Risk of venous thrombosis in carriers of a common mutation in the homocysteine regulatory enzyme methylenetetrahydrofolate reductase*

Chelex 100 as a Medium for Simple Extraction of DNA for PCR-Based Typing from Forensic Material

2013 • 5,893 citations

Mutation in blood coagulation factor V associated with resistance to activated protein C

1994 • 3,871 citations

A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease

1995 • 3,645 citations

Vitamin Status and Intake as Primary Determinants of Homocysteinemia in an Elderly Population

1993 • 1,920 citations

Relation Between Folate Status, a Common Mutation in Methylenetetrahydrofolate Reductase, and Plasma Homocysteine Concentrations

1996 • 1,423 citations

The natural history of homocystinuria due to cystathionine beta-synthase deficiency.

1985 • 1,251 citations

Natural history of pulmonary embolism

1975 • 1,137 citations

Mutation in the Gene Coding for Coagulation Factor V and the Risk of Myocardial Infarction, Stroke, and Venous Thrombosis in Apparently Healthy Men

1995 • 1,060 citations

Total Plasma Homocysteine and Cardiovascular Risk Profile

1995 • 1,048 citations

Hyperhomocysteinemia as a Risk Factor for Deep-Vein Thrombosis

1996 • 1,034 citations

Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida

1995 • 870 citations

Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.

1996 • 670 citations

Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient families

1994 • 446 citations

Rapid HPLC determination of total homocysteine and other thiols in serum and plasma: sex differences and correlation with cobalamin and folate concentrations in healthy subjects

1994 • 437 citations

Is hyperhomocysteinaemia a risk factor for recurrent venous thrombosis?

1995 • 374 citations

Resistance to activated protein C as an additional genetic risk factor in hereditary deficiency of protein S

1995 • 314 citations

Inherited thrombophilia: resistance to activated protein C as a pathogenic factor of venous thromboembolism

1995 • 307 citations

Coexistence of Hereditary Homocystinuria and Factor V Leiden — Effect on Thrombosis

1996 • 266 citations

Factor V Leiden and Risks of Recurrent Idiopathic Venous Thromboembolism

1995 • 251 citations

High prevalence of hyperhomocyst(e)inemia in patients with juvenile venous thrombosis.

1994 • 251 citations

Prevalence of Moderate Hyperhomocysteinemia in Patients with Early-Onset Venous and Arterial Occlusive Disease

1995 • 235 citations

Common Mutation in Methylenetetrahydrofolate Reductase

1996 • 226 citations

Distribution in Healthy and Coronary Populations of the Methylenetetrahydrofolate Reductase (MTHFR) C ₆₇₇ T Mutation

1996 • 173 citations

Factor V Leiden: An Additional Risk Factor for Thrombosis in Protein S Deficient Families?

1995 • 152 citations

A Single Mutation of the Fumarylacetoacetate Hydrolase Gene in French Canadians with Hereditary Tyrosinemia Type I

1994 • 133 citations

Incidence of activated protein C resistance caused by the ARG 506 GLN mutation in factor V in 113 unrelated symptomatic protein C-deficient patients. The French Network on the behalf of INSERM

1995 • 119 citations

Ischemic Stroke in the Elderly

1996 • 101 citations

Elevated total plasma homocysteine, a risk factor for thrombosis. Relation to coagulation and fibrinolytic parameters

1993 • 99 citations

Higher Plasma Homocyst(e)ine and Increased Susceptibility to Adverse Effects of Low Folate in Early Familial Coronary Artery Disease

1995 • 89 citations

Molecular Detection of a Common Mutation in Coagulation Factor V Causing Thrombosis via Hereditary Resistance to Activated Protein C

1995 • 46 citations