Localization of 70 kDa Stress Protein mRNA Induction in Gerbil Brain after Ischemia

THE HEAT-SHOCK PROTEINS

1988 • 5,214 citations

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

1984 • 2,884 citations

Glutamate and the pathophysiology of hypoxic–ischemic brain damage

1986 • 2,428 citations

Expression of c- fos Protein in Brain: Metabolic Mapping at the Cellular Level

1988 • 1,916 citations

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

Mapping Patterns of c- fos Expression in the Central Nervous System After Seizure

1987 • 1,771 citations

A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides

1988 • 1,504 citations

Interaction of Hsp 70 with Newly Synthesized Proteins: Implications for Protein Folding and Assembly

1990 • 1,293 citations

70K heat shock related proteins stimulate protein translocation into microsomes

1988 • 1,276 citations

Greenfield's Neuropathology

1985 • 1,149 citations

Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70.

1985 • 860 citations

Peptide Binding and Release by Proteins Implicated as Catalysts of Protein Assembly

1989 • 763 citations

Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia

1990 • 589 citations

Effect of protein synthesis inhibitors on growth factor activation of c-fos, c-myc, and actin gene transcription.

1986 • 548 citations

Regulation of Proenkephalin by Fos and Jun

1989 • 546 citations

The heat shock response is self-regulated at both the transcriptional and posttranscriptional levels

1982 • 542 citations

Cellular and biochemical events in mammalian cells during and after recovery from physiological stress.

1986 • 513 citations

Localization of 70-kDa stress protein induction in gerbil brain after ischemia

1988 • 465 citations

Purification and Properties of Drosophila Heat Shock Activator Protein

1987 • 388 citations

Persistent inhibition of protein synthesis precedes delayed neuronal death in postischemic gerbil hippocampus

1986 • 380 citations

Quantitative in situ hybridization histochemistry reveals increased levels of corticotropin-releasing factor mRNA after adrenalectomy in rats

1986 • 377 citations

The effects of 5-minute ischemia in Mongolian gerbils: II. Changes of spontaneous neuronal activity in cerebral cortex and CA1 sector of hippocampus

1983 • 356 citations

Glutamate receptor agonists increase the expression of Fos, Fra, and AP‐1 DNA binding activity in the mammalian brain

1989 • 330 citations

Human HSP70 promoter contains at least two distinct regulatory domains.

1986 • 326 citations

N-methyl-D-aspartate receptors mediate hypoxic neuronal injury in cortical culture.

1987 • 309 citations

Heat shock proteins as markers of neural injury

1989 • 304 citations

MK-801 is neuroprotective in gerbils when administered during the post-ischaemic period

1988 • 276 citations

Regulation of heat shock protein 70 gene expression by c-myc

1984 • 270 citations

Synthesis of a Stress Protein Following Transient Ischemia in the Gerbil

1985 • 270 citations

Fine structural nature of delayed neuronal death following ischemia in the gerbil hippocampus

1984 • 253 citations

Evidence for amelioration of ischaemic neuronal damage in the hippocampal formation by lesions of the perforant path

1985 • 247 citations

Transcription of the human hsp70 gene is induced by serum stimulation.

1985 • 235 citations

Regional Protein Synthesis in Rat Brain Following Acute Hemispheric Ischemia

1980 • 231 citations

Brain injury induces c-fos protein(s) in nerve and glial-like cells in adult mammalian brain

1988 • 223 citations

Generalized seizures induce c-fos protein(s) in mammalian neurons

1987 • 212 citations

Heat Shock RNA Levels in Brain and Other Tissues After Hyperthermia and Transient Ischemia

1990 • 199 citations

Induction of a heat shock gene at the site of tissue injury in the rat brain

1989 • 183 citations

Induction of stress protein HSP70 in nerve cells after status epilepticus in the rat

1989 • 179 citations

Delayed c-fos proto-oncogene expression in the rat hippocampus induced by transient global cerebral ischemia: an in situ hybridization study

1989 • 178 citations

Heat shock proteins are methylated in avian and mammalian cells.

1981 • 173 citations

Central mammalian neurons normally resistant to glutamate toxicity are made sensitive by elevated extracellular Ca2+: toxicity is blocked by the N-methyl-D-aspartate antagonist MK-801.

1988 • 168 citations

Long-lasting and sequential increase of c-fos oncoprotein expression in kainic acid-induced status epilepticus

1988 • 165 citations

[7] Terminal transferase-catalyzed addition of nucleotides to the 3′ termini of DNA

1980 • 164 citations

Proto-oncogene c-fos is transiently induced in the rat cerebral cortex after forebrain ischemia

1989 • 149 citations

Selective induction of a heat shock gene in fibre tracts and cerebellar neurons of the rabbit brain detected by in situ hybridization

1987 • 145 citations

Complex modes of heat shock factor activation.

1990 • 141 citations

70‐Kilodalton Heat Shock Protein Induction in Cerebellar Astrocytes and Cerebellar Granule Cells In Vitro: Comparison with Immunocytochemical Localization After Hyperthermia In Vivo

1990 • 140 citations

Continuous lidocaine infusion and focal feline cerebral ischemia.

1990 • 140 citations

Synthesis of Heat Shock Proteins in Rat Brain Cortex after Transient Ischemia

1986 • 129 citations

Ischemic CA-1 pyramidal cell loss is prevented by preischemic colchicine destruction of dentate gyrus granule cells

1986 • 127 citations

Removal of the entorhinal cortex protects hippocampal CA-1 neurons from ischemic damage

1987 • 126 citations

Selective Gene Expression in Focal Cerebral Ischemia

1986 • 123 citations

Mouse Brain c‐fos mRNA Distribution Following a Single Electroconvulsive Shock

1989 • 106 citations

The heat shock response in HeLa cells is accompanied by elevated expression of the c-fos proto-oncogene.

1987 • 106 citations

Protein Synthesis in Postischemic Rat Brain: A Two-Dimensional Electrophoretic Analysis

1986 • 99 citations

Impairment of protein ubiquitination may cause delayed neuronal death

1989 • 96 citations

Synthesis of the major inducible heat shock protein in rat hippocampus after neonatal hypoxia-ischemia

1989 • 92 citations

c-fos mRNA levels are increased by the cellular stressors, heat shock and sodium arsenite.

1988 • 72 citations

Hippocampal unit activity after transient cerebral ischemia in rats.

1989 • 64 citations

The mechanism of ischemia-induced brain cell injury

1988 • 51 citations

Selective vulnerability of brain: New insights from the excitatory synapse

1986 • 50 citations

C-fos mRNA expression following electrical-induced seizure and acute nociceptive stress in mouse brain

1989 • 48 citations

Experimental stroke in gerbils: Effect on translation and transcription

1978 • 39 citations

Heat shock induces c-fos protein-like immunoreactivity in glial cells in adult rat brain

1989 • 39 citations

Cerebral Ischemia in Gerbils: Differential Vulnerability of Protein, RNA, and Lipid Syntheses

1976 • 30 citations

[40] RNA detection and localization in cells and tissue sections by in Situ hybridization of 35S-labeled RNA probes

1987 • 26 citations

[Changes in protein and RNA synthesis following acute hindbrain ischemia].

1987 • 1 citations