Central mammalian neurons normally resistant to glutamate toxicity are made sensitive by elevated extracellular Ca2+: toxicity is blocked by the N-methyl-D-aspartate antagonist MK-801.

Magnesium gates glutamate-activated channels in mouse central neurones

1984 • 3,999 citations

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

1986 • 1,842 citations

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

Ionic dependence of glutamate neurotoxicity

1987 • 1,811 citations

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

1986 • 1,283 citations

The Toxic Effect of Sodium L-Glutamate on the Inner Layers of the Retina

1957 • 1,061 citations

Histocompatibility Testing 1965

1966 • 1,036 citations

Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists

1988 • 983 citations

Permeation and block of N‐methyl‐D‐aspartic acid receptor channels by divalent cations in mouse cultured central neurones.

1987 • 934 citations

Guam Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Linked to a Plant Excitant Neurotoxin

1987 • 881 citations

Glutamate neurotoxicity in cortical cell culture is calcium dependent

1985 • 818 citations

Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels.

1988 • 747 citations

Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil

1987 • 647 citations

The action of N‐methyl‐D‐aspartic acid on mouse spinal neurones in culture.

1985 • 417 citations

Selective depression of excitatory amino acid induced depolarizations by magnesium ions in isolated spinal cord preparations.

1980 • 398 citations

Delayed neurotoxicity of excitatory amino acids In vitro

1987 • 332 citations

Neurons Containing NADPH-Diaphorase Are Selectively Resistant to Quinolinate Toxicity

1986 • 292 citations

Agonist- and voltage-gated calcium entry in cultured mouse spinal cord neurons under voltage clamp measured using arsenazo III

1987 • 288 citations

Glutamate Antagonist Therapy Reduces Neurologic Deficits Produced by Focal Central Nervous System Ischemia

1988 • 245 citations

Voltage‐dependent conductances of solitary ganglion cells dissociated from the rat retina.

1987 • 199 citations

Monoclonal Antibody to Thy-1 Enhances Regeneration of Processes by Rat Retinal Ganglion Cells In Culture

1984 • 190 citations

Ionic requirements for neurotoxic effects of excitatory amino acid analogues in rat cerebellar slices

1986 • 153 citations

Blockade of electrical activity promotes the death of mammalian retinal ganglion cells in culture.

1986 • 147 citations

Responses mediated by excitatory amino acid receptors in solitary retinal ganglion cells from rat.

1988 • 145 citations

MK-801 powerfully protects against N-methyl aspartate neurotoxicity

1987 • 141 citations

Kainic acid: neurotoxic effects after intraocular injection.

1977 • 127 citations

The interaction of agonists and noncompetitive antagonists at the excitatory amino acid receptors in rat retinal ganglion cells in vitro

1988 • 71 citations

Kainic acid affects both plexiform layers of chicken retina

1981 • 67 citations

The novel anticonvulsant MK-801 interacts with central phencyclidine recognition sites in rat brain

1987 • 63 citations

Brain calcium content in ischemic infarction

1987 • 32 citations

Changes of electroretinogram and neurochemical aspects of gabaergic neurons of retina after intraocular injection of kainic acid in rats

1981 • 25 citations

Specific ganglion cell death induced by intravitreal kainic acid in the chicken retina

1987 • 15 citations