Glutathione transferases as mediators of signaling pathways involved in cell proliferation and cell death

Glutathione S-Transferases

1974 • 17,321 citations

The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I

1995 • 3,492 citations

GLUTATHIONE TRANSFERASES

2004 • 3,229 citations

Regulation of JNK signaling by GSTp

1999 • 1,102 citations

Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties.

1985 • 1,081 citations

Glutathione-Associated Enzymes In Anticancer Drug Resistance

2016 • 864 citations

Theta, a new class of glutathione transferases purified from rat and man

1991 • 743 citations

Molecular Cloning, Characterization, and Expression in Escherichia coli of Full-length cDNAs of Three Human Glutathione S-Transferase Pi Gene Variants

1997 • 716 citations

Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution

1998 • 678 citations

Ligandin: a Hepatic Protein which Binds Steroids, Bilirubin, Carcinogens and a Number of Exogenous Organic Anions

1971 • 570 citations

Zeta, a novel class of glutathione transferases in a range of species from plants to humans

1997 • 498 citations

The Identity of Glutathione S -Transferase B with Ligandin, a Major Binding Protein of Liver

1974 • 491 citations

4‐Hydroxyalk‐2‐enals are substrates for glutathione transferase

1985 • 422 citations

From JNK to Pay Dirt: Jun Kinases, their Biochemistry, Physiology and Clinical Importance

2005 • 406 citations

Glutathione S-Transferase Mu Modulates the Stress-activated Signals by Suppressing Apoptosis Signal-regulating Kinase 1

2001 • 397 citations

Glutathione S-transferase P1–1 (GSTP1–1) Inhibits c-Jun N-terminal Kinase (JNK1) Signaling through Interaction with the C Terminus

2001 • 304 citations

Nomenclature for Mammalian Soluble Glutathione Transferases

2005 • 302 citations

Regulation of 4-hydroxynonenal-mediated signaling by glutathione S-transferases

2004 • 267 citations

Glutathione S-transferase p elicits protection against H2O2-induced cell death via coordinated regulation of stress kinases.

2000 • 263 citations

Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2–ASK1 signals

2006 • 222 citations

Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance

2007 • 206 citations

Human Glutathione Transferase A3-3, a Highly Efficient Catalyst of Double-bond Isomerization in the Biosynthetic Pathway of Steroid Hormones

2001 • 201 citations

The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution

1997 • 178 citations

Glutathione-associated enzymes in the human cell lines of the National Cancer Institute Drug Screening Program.

1996 • 176 citations

Pharmacologic or genetic manipulation of glutathione S-transferase P1-1 (GSTpi) influences cell proliferation pathways.

2001 • 164 citations

Increased Constitutive c-Jun N-terminal Kinase Signaling in Mice Lacking Glutathione S-Transferase Pi

2003 • 157 citations

7-Nitro-2,1,3-benzoxadiazole Derivatives, a New Class of Suicide Inhibitors for Glutathione S-Transferases

2005 • 139 citations

Identification of an anionic form of glutathione transferase present in many human tumors and human tumor cell lines.

1988 • 137 citations

Coordinated Action of Glutathione S-Transferases (GSTs) and Multidrug Resistance Protein 1 (MRP1) in Antineoplastic Drug Detoxification

1998 • 136 citations

Transport of glutathione diethyl ester into human cells.

1993 • 118 citations

Isozyme-specific glutathione S-transferase inhibitors potentiate drug sensitivity in cultured human tumor cell lines

1996 • 116 citations

Proapoptotic Activity of New Glutathione S-Transferase Inhibitors

2005 • 111 citations

The chemistry and biology of inhibitors and pro-drugs targeted to glutathione S-transferases

2005 • 106 citations

Expression of class Pi glutathione transferase in human malignant melanoma cells

1987 • 105 citations

Monomer−Dimer Equilibrium in Glutathione Transferases: A Critical Re-Examination

2009 • 102 citations

Identification of mu-class glutathione transferases M2-2 and M3-3 as cytosolic prostaglandin E synthases in the human brain.

2000 • 101 citations

The glutathione-binding site in glutathione S-transferases. Investigation of the cysteinyl, glycyl and γ-glutamyl domains

1990 • 98 citations

Expression of glutathione transferase pi as a predictor for treatment results at different stages of acute nonlymphoblastic leukemia.

1992 • 97 citations

Isoenzyme-specific glutathione-S-transferase inhibitors: design and synthesis

1994 • 88 citations

Differential effects of glutathione S-transferase pi (GSTP1) haplotypes on cell proliferation and apoptosis

2007 • 86 citations

Structural Basis for the Binding of the Anticancer Compound 6-(7-Nitro-2,1,3-Benzoxadiazol-4-Ylthio)Hexanol to Human Glutathione S-Transferases

2009 • 84 citations

Role of glutathione in cellular resistance to alkylating agents

1993 • 83 citations

Increased Myeloproliferation in Glutathione S-Transferase π-deficient Mice Is Associated with a Deregulation of JNK and Janus Kinase/STAT Pathways

2004 • 82 citations

Detection of drug-induced apoptosis and necrosis in human cervical carcinoma cells using 1H NMR spectroscopy

2001 • 82 citations

Human GSTA1-1 reduces c-Jun N-terminal kinase signalling and apoptosis in Caco-2 cells

2006 • 82 citations

Glutathione Transferases as Targets for Cancer Therapy

2009 • 82 citations

Thiazolides inhibit growth and induce glutathione‐S‐transferase Pi (GSTP1)‐dependent cell death in human colon cancer cells

2008 • 82 citations

Ethacrynic acid and its glutathione conjugate as inhibitors of glutathioneS-transferases

1993 • 81 citations

Critical role of oxidative stress and sustained JNK activation in aloe-emodin-mediated apoptotic cell death in human hepatoma cells

2007 • 78 citations

The human glutathione S-transferases: Developmental aspects of the GST1, GST2, and GST3 loci

1985 • 77 citations

Identification of Cysteine Residues Involved in Disulfide Formation in the Inactivation of Glutathione Transferase P-Form by Hydrogen Peroxide

1993 • 75 citations

Significance of an unusually lowK_mfor glutathione in glutathione transferases of the α μ and π classes

1993 • 64 citations

Phase 1 multicenter dose-escalation study of ezatiostat hydrochloride (TLK199 tablets), a novel glutathione analog prodrug, in patients with myelodysplastic syndrome

2009 • 62 citations

Studies of the development of basic, neutral and acidic isoenzymes of glutathione S-transferase in human liver, adrenal, kidney and spleen

1987 • 62 citations

Phase 1-2a multicenter dose-escalation study of ezatiostat hydrochloride liposomes for injection (Telintra®, TLK199), a novel glutathione analog prodrug in patients with myelodysplastic syndrome

2009 • 58 citations

Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD‐1 and suppression by N‐acetyl‐<scp>l</scp>‐cysteine

2003 • 52 citations

Negative Regulation of MEKK1-induced Signaling by Glutathione S-Transferase Mu

2004 • 51 citations

Advance in Antitumor Agents Targeting Glutathione-S-Transferase

2006 • 48 citations

Modulation of GST P1-1 activity by polymerization during apoptosis

2000 • 48 citations

Association between glutathione-S-transferase GSTP1 genotypes, GSTP1 over-expression, and outcome in epithelial ovarian cancer

2004 • 46 citations

Two distinct forms of glutathione transferase from human foetal liver. Purification and comparison with isoenzymes isolated from adult liver and placenta

1986 • 46 citations

Peptidomimetic Glutathione Analogues as Novel γGT Stable GST Inhibitors

2002 • 46 citations

Novel Class of Bivalent Glutathione S-Transferase Inhibitors

2003 • 45 citations

The polymorphic human glutathione transferase T1-1, the most efficient glutathione transferase in the denitrosation and inactivation of the anticancer drug 1,3-bis(2-chloroethyl)-1-nitrosourea

2002 • 43 citations

Peptide-bond modified glutathione conjugate analogs modulate GSTπ function in GSH-conjugation, drug sensitivity and JNK signaling

2005 • 38 citations

Benastatins A and B, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. I. Taxonomy, production, isolation, physico-chemical properties and biological activities.

1992 • 35 citations

In vitro and in vivo efficacy of 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) on human melanoma

2009 • 33 citations

Glutathione analogues in cancer treatment

2004 • 29 citations

Synthesis and activity of novel glutathione analogues containing an urethane backbone linkage

2003 • 28 citations

Conformational change in the active center region of GST P1-1, due to binding of a synthetic conjugate of DXR with GSH, enhanced JNK-mediated apoptosis

2007 • 25 citations

Ligand-based protein alignment and isozyme specificity of glutathioneS-transferase inhibitors

1997 • 25 citations

Phosphono analogs of glutathione: inhibition of glutathione transferases, metabolic stability, and uptake by cancer cells

2000 • 25 citations

Benastatins C and D, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. Production, isolation, structure determination and biological activities.

1993 • 25 citations

Structure of the human allelic glutathione S-transferase-π gene variant, hGSTP1*C, cloned from a glioblastoma multiforme cell line

1998 • 24 citations

Glutathione-doxorubicin conjugate expresses potent cytotoxicity by suppression of glutathione S-transferase activity: comparison between doxorubicin-sensitive and -resistant rat hepatoma cells

1997 • 23 citations

Mechanism of action of potential anticancer drugs

2008 • 22 citations

Haloenol Lactone Is a New Isozyme-selective and Active Site-directed Inactivator of Glutathione S-Transferase

1996 • 19 citations

Suppression of GST-P by treatment with glutathione-doxorubicin conjugate induces potent apoptosis in rat hepatoma cells

2001 • 19 citations

Proposed intracellular regulatory functions of glutathione transferases by recognition and binding to S‐glutathiolated proteins

2005 • 17 citations

Chapter 20 Small-Molecule Inhibitors of Glutathione S-Transferase P1-1 as Anticancer Therapeutic Agents

2007 • 17 citations

The Human Glutathione Transferase P1-1 Specific Inhibitor TER 117 Designed for Overcoming Cytostatic-Drug Resistance Is also a Strong Inhibitor of Glyoxalase I

2000 • 16 citations

Purification and characterization of rat testicular glutathione S-transferases: role in the synthesis of eicosanoids.

2000 • 15 citations

Phosphono Analogues of Glutathione as New Inhibitors of Glutathione S‐Transferases

1996 • 13 citations

Human renal UOK130 tumor cells: A drug resistant cell line with highly selective over-expression of glutathione S-transferase-π isozyme

2007 • 11 citations

TWO DISTINCT FORMS OF GLUTATHIONE TRANSFERASE FROM HUMAN FOETAL LIVER

1986 • 10 citations

Association between glutathione-S-transferase GSTP1 genotypes, GSTP1 over-expression, and outcome in epithelial ovarian cancer

2004 • 10 citations

Mechanistic Studies of Inactivation of Glutathione S-transferase Pi Isozyme by a Haloenol Lactone Derivative

2005 • 8 citations