Immunopathogenesis of psoriasis

Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

2005 • 4,573 citations

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

2005 • 4,165 citations

Matrix Metalloproteinases

1999 • 3,774 citations

Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance

2004 • 2,910 citations

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

1995 • 2,531 citations

THE B7 FAMILY REVISITED

2005 • 2,239 citations

Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides

2006 • 2,234 citations

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

1995 • 2,090 citations

Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

1998 • 2,048 citations

Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

2006 • 1,806 citations

The cornified envelope: a model of cell death in the skin

2005 • 1,639 citations

INTERMEDIATE FILAMENTS: Structure, Dynamics, Function and Disease

1994 • 1,408 citations

Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties

2006 • 1,403 citations

IL-22 Increases the Innate Immunity of Tissues

2004 • 1,330 citations

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells

1997 • 1,143 citations

Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the αEβ7 integrin

1994 • 1,131 citations

Macrophages and angiogenesis

1994 • 1,123 citations

A Large-Scale Genetic Association Study Confirms IL12B and Leads to the Identification of IL23R as Psoriasis-Risk Genes

2007 • 1,070 citations

Plasmacytoid predendritic cells initiate psoriasis through interferon-α production

2005 • 1,063 citations

Psoriasis: epidemiology, clinical features, and quality of life

2005 • 998 citations

Psoriasis of early and late onset: Characterization of two types of psoriasis vulgaris

1985 • 993 citations

Psoriasis − epidemiology and clinical spectrum

2001 • 949 citations

Psoriasis

2005 • 904 citations

IL‐22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis

2006 • 898 citations

Increased Expression of Interleukin 23 p19 and p40 in Lesional Skin of Patients with Psoriasis Vulgaris

2004 • 873 citations

Production and auto-induction of transforming growth factor-α in human keratinocytes

1987 • 870 citations

Regulation of Dendritic Cell Migration to the Draining Lymph Node

2003 • 863 citations

The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells

1999 • 839 citations

Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo.

1996 • 800 citations

CCL27–CCR10 interactions regulate T cell–mediated skin inflammation

2002 • 773 citations

Developmental regulation of MHC class II transport in mouse dendritic cells

1997 • 754 citations

Activation of Lysosomal Function During Dendritic Cell Maturation

2003 • 703 citations

Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model

2004 • 693 citations

Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis.

1994 • 680 citations

IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2–dependent mechanisms with implications for psoriasis pathogenesis

2006 • 662 citations

Epidermal differentiation: the bare essentials.

1990 • 651 citations

Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis

1995 • 622 citations

Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells

1997 • 582 citations

Cutting Edge: Immune Cells as Sources and Targets of the IL-10 Family Members?

2002 • 580 citations

Interleukin-17 and Interferon-γ Synergize in the Enhancement of Proinflammatory Cytokine Production by Human Keratinocytes

1998 • 565 citations

Dysfunctional Blood and Target Tissue CD4+CD25high Regulatory T Cells in Psoriasis: Mechanism Underlying Unrestrained Pathogenic Effector T Cell Proliferation

2005 • 561 citations

Interleukin 20

2001 • 542 citations

Overexpression of Transforming Growth Factor α in Psoriatic Epidermis

1989 • 537 citations

Interleukin (IL)-22, a Novel Human Cytokine That Signals through the Interferon Receptor-related Proteins CRF2–4 and IL-22R

2000 • 531 citations

Cathepsin S Required for Normal MHC Class II Peptide Loading and Germinal Center Development

1999 • 519 citations

Characterization of intercellular adhesion molecule-1 and HLA-DR expression in normal inflamed skin: Modulation by recombinant gamma interferon and tumor necrosis factor

1989 • 505 citations

CC Chemokine Receptor (CCR)4 and the CCR10 Ligand Cutaneous T Cell–attracting Chemokine (CTACK) in Lymphocyte Trafficking to Inflamed Skin

2001 • 502 citations

Spontaneous Development of Psoriasis in a New Animal Model Shows an Essential Role for Resident T Cells and Tumor Necrosis Factor-α

2004 • 484 citations

Degradation of Corneodesmosome Proteins by Two Serine Proteases of the Kallikrein Family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7

2004 • 483 citations

Transport of Peptide-MHC Class II Complexes in Developing Dendritic Cells

2000 • 483 citations

The Majority of Epidermal T Cells in Psoriasis Vulgaris Lesions can Produce Type 1 Cytokines, Interferon-γ, Interleukin-2, and Tumor Necrosis Factor-α, Defining TC1 (Cytotoxic T Lymphocyte) and TH1 Effector Populations:1 a Type 1 Differentiation Bias is also Measured in Circulating Blood T Cells in Psoriatic Patients

1999 • 479 citations

Getting under the skin: the immunogenetics of psoriasis

2005 • 465 citations

T Cells Involved in Psoriasis Vulgaris Belong to the Th1 Subset

1994 • 451 citations

Plasmacytoid Dendritic Cells: A New Cutaneous Dendritic Cell Subset with Distinct Role in Inflammatory Skin Diseases

2002 • 450 citations

Increase in TNF-α and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)

2005 • 446 citations

Dermal injection of immunocytes induces psoriasis.

1996 • 441 citations

Developmental Control of Endocytosis in Dendritic Cells by Cdc42

2000 • 440 citations

Cellular localization of interleukin-8 and its inducer, tumor necrosis factor-alpha in psoriasis.

1991 • 437 citations

Mechanisms of MHC class I‐restricted antigen processing and cross‐presentation

2005 • 422 citations

Distinct Roles for LFA-1 and CD28 during Activation of Naive T Cells: Adhesion versus Costimulation

1997 • 411 citations

Impaired Invariant Chain Degradation and Antigen Presentation and Diminished Collagen-Induced Arthritis in Cathepsin S Null Mice

1999 • 408 citations

Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines

2005 • 405 citations

Keratins and the Skin

1995 • 402 citations

Psoriasis Triggered by Toll-like Receptor 7 Agonist Imiquimod in the Presence of Dermal Plasmacytoid Dendritic Cell Precursors

2004 • 399 citations

Developmental Regulation of Invariant Chain Proteolysis Controls MHC Class II Trafficking in Mouse Dendritic Cells

1998 • 378 citations

Macrophage Inflammatory Protein 3α Is Expressed at Inflamed Epithelial Surfaces and Is the Most Potent Chemokine Known in Attracting Langerhans Cell Precursors

2000 • 377 citations

EBI1/CCR7 Is a New Member of Dendritic Cell Chemokine Receptor That Is Up-Regulated upon Maturation

1998 • 377 citations

Epithelial Wound Healing Enhanced by Transforming Growth Factor-α and Vaccinia Growth Factor

1987 • 368 citations

Characterization of factor XIIIa positive dermal dendritic cells in normal and inflamed skin

1989 • 351 citations

The Role of Streptococcal Infection in the Initiation of Guttate Psoriasis

1992 • 333 citations

Subsecond Induction of α4 Integrin Clustering by Immobilized Chemokines Stimulates Leukocyte Tethering and Rolling on Endothelial Vascular Cell Adhesion Molecule 1 under Flow Conditions

2000 • 327 citations

Characterization of dermal dendritic cells in psoriasis. Autostimulation of T lymphocytes and induction of Th1 type cytokines.

1994 • 299 citations

Interleukin-22: A novel T- and NK-cell derived cytokine that regulates the biology of tissue cells

2006 • 299 citations

Keratins (Kl6 and Kl7) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro

1995 • 291 citations

Interleukin-17 is Produced by Both Th1 and Th2 Lymphocytes, and Modulates Interferon-γ- and Interleukin-4-Induced Activation of Human Keratinocytes

2000 • 289 citations

Cyclosporin a for Psoriasis

1979 • 288 citations

Janus-like role of regulatory iNKT cells in autoimmune disease and tumour immunity

2003 • 278 citations

Prevalence of Joint Disease in Patients with Psoriasis

2003 • 272 citations

Specialized Contributions by α(1,3)-Fucosyltransferase-IV and FucT-VII during Leukocyte Rolling in Dermal Microvessels

2000 • 261 citations

The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules

2004 • 256 citations

Activated macrophages are essential in a murine model for T cell-mediated chronic psoriasiform skin inflammation

2006 • 251 citations

Psoriasis in the community: prevalence, severity and patients' beliefs and attitudes towards the disease

1996 • 246 citations

Streptococcal throat infections and exacerbation of chronic plaque psoriasis: a prospective study

2003 • 246 citations

Immunocompetent cells in psoriasis

1983 • 241 citations

Impaired Wound Contraction in Stromelysin-1–Deficient Mice

1999 • 232 citations

Interleukin (IL)‐19, IL‐20 and IL‐24 are produced by and act on keratinocytes and are distinct from classical ILs

2006 • 231 citations

Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes

2006 • 230 citations

Psoriatic scales: a promising source for the isolation of human skin-derived antimicrobial proteins

2005 • 229 citations

Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis

2007 • 229 citations

Endotoxin-mediated dendritic cell release from the intestine. Characterization of released dendritic cells and TNF dependence.

1995 • 226 citations

CD56^brightCD16^– NK cells accumulate in psoriatic skin in response to CXCL10 and CCL5 and exacerbate skin inflammation

2005 • 225 citations

Kinetics and regulation of human keratinocyte stem cell growth in short-term primary ex vivo culture. Cooperative growth factors from psoriatic lesional T lymphocytes stimulate proliferation among psoriatic uninvolved, but not normal, stem keratinocytes.

1995 • 223 citations

Evolution, maturation, and regression of lesions of lichen planus

1981 • 221 citations

Predominance of ?memory? T cells (CD4+, CDw29+) over ?naive? T cells (CD4+, CD45R+) in both normal and diseased human skin

1989 • 218 citations

Overexpression of CD1d by Keratinocytes in Psoriasis and CD1d-Dependent IFN-γ Production by NK-T Cells

2000 • 218 citations

Prevalence of psoriasis in Spain (Epiderma Project: phase I)

2001 • 215 citations

Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of major histocompatibility complex class II molecules and expression of invariant chain.

1990 • 214 citations

Potential Role of the Chemokine Receptors CXCR3, CCR4, and the Integrin αEβ7 in the Pathogenesis of Psoriasis Vulgaris

2001 • 212 citations

CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking

2003 • 210 citations

Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation

2006 • 208 citations

Expression and Function of Nerve Growth Factor and Nerve Growth Factor Receptor on Cultured Keratinocytes

1994 • 188 citations

Resident Skin-specific γδ T Cells Provide Local, Nonredundant Regulation of Cutaneous Inflammation

2002 • 188 citations

Nerve growth factor binds to normal human keratinocytes through high and low affinity receptors and stimulates their growth by a novel autocrine loop.

1993 • 187 citations

Clearance of severe psoriasis after allogenic bone marrow transplantation.

1990 • 176 citations

Keratinocyte growth regulation by the products of immune cells.

1988 • 172 citations

Accessory cell function of keratinocytes for superantigens. Dependence on lymphocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction.

1993 • 171 citations

Evolution, maturation, and regression of lesions of psoriasis

1979 • 169 citations

Localization of tumour necrosis factor-alpha (TNF-α) and its receptors in normal and psoriatic skin: epidermal cells express the 55-kD but not the 75-kD TNF receptor

1993 • 168 citations

Epidermal Overexpression of Interleukin-19 and -20 mRNA in Psoriatic Skin Disappears After Short-Term Treatment with Cyclosporine A or Calcipotriol

2003 • 168 citations

Dendritic cell trafficking: More than just chemokines

2005 • 165 citations

Drug-Induced Psoriasis

2000 • 165 citations

Control of MHC class II antigen presentation in dendritic cells: a balance between creative and destructive forces

2005 • 164 citations

CD69, HLA-DR and the IL-2R Identify Persistently Activated T Cells in Psoriasis Vulgaris Lesional Skin: Blood and Skin Comparisons by Flow Cytometry

2000 • 160 citations

Maturation of Dendritic Cells Is Accompanied by Rapid Transcriptional Silencing of Class II Transactivator (Ciita) Expression

2001 • 158 citations

The immunological synapse: integrins take the stage

2002 • 151 citations

The genetics of psoriasis.

1972 • 144 citations

Peripheral blood T cell responses to keratin peptides that share sequences with streptococcal M proteins are largely restricted to skin-homing CD8+ T cells

2004 • 144 citations

Identical TCR β-Chain Rearrangements in Streptococcal Angina and Skin Lesions of Patients with Psoriasis Vulgaris

2006 • 140 citations

Gamma interferon induces different keratinocyte cellular patterns of expression of HLA-DR and DQ and intercellular adhesion molecule-I (ICAM-I) antigens

1989 • 139 citations

Role of Integrin αE(CD103)β7 for Tissue-Specific Epidermal Localization of CD8+ T Lymphocytes

2001 • 134 citations

Flow cytometric identification of proliferative subpopulations within normal human epidermis and the localization of the primary hyperproliferative population in psoriasis.

1993 • 131 citations

Natural killer and natural killer-T cells in psoriasis

2002 • 130 citations

FOXP3⁺ regulatory T cells: Current controversies and future perspectives

2006 • 130 citations

Altered Expression of Angiopoietins and Tie2 Endothelium Receptor in Psoriasis

2001 • 126 citations

Cytokine Regulation of Proliferation and ICAM-1 Expression of Human Dermal Microvascular Endothelial Cells In Vitro

1992 • 122 citations

HLA-DM Is Localized to Conventional and Unconventional MHC Class II–Containing Endocytic Compartments

1996 • 122 citations

Efficiency of Acitretin in Combination With UV-B in the Treatment of Severe Psoriasis

1990 • 121 citations

Response to injury of skin involved and uninvolved with psoriasis, and its relation to disease activity: Koebner and'reverse'Koebner reactions

1982 • 121 citations

An important role of tumor necrosis factor-α in the induction of adhesion molecules in psoriasis

1998 • 119 citations

Abnormal Sequence of Expression of Differentiation Markers in Psoriatic Epidermis: Inversion of Two Steps in the Differentiation Program?

1988 • 118 citations

Characterization of Mononuclear Cell Infiltrates in Psoriatic Lesions

1978 • 114 citations

The dynamics of gene expression of interleukin-19 and interleukin-20 and their receptors in psoriasis

2005 • 112 citations

CD43 is a ligand for E-selectin on CLA+ human T cells

2005 • 111 citations

Cutting Edge: CD1a+ Antigen-Presenting Cells in Human Dermis Respond Rapidly to CCR7 Ligands

2006 • 111 citations

Severe combined immunodeficiency mouse and human psoriatic skin chimeras. Validation of a new animal model.

1995 • 108 citations

Is an epitope on keratin 17 a major target for autoreactive T lymphocytes in psoriasis?

1999 • 108 citations

Is there an interaction between interleukin-10 and interleukin-22?

2004 • 107 citations

Cross-reactivity between streptococcal M surface antigen and human skin

1991 • 106 citations

Detection of IL-20 and its receptors on psoriatic skin

2005 • 106 citations

The Genetics of Psoriasis

1972 • 104 citations

Plaque psoriasis vs. atopic dermatitis and lichen planus: a comparison for lesional T-cell subsets, epidermal proliferation and differentiation

2005 • 104 citations

Group A streptococcal antigen-specific T lymphocytes in guttate psoriatic lesions

1993 • 97 citations

K252a, a High-Affinity Nerve Growth Factor Receptor Blocker, Improves Psoriasis: An In Vivo Study Using the Severe Combined Immunodeficient Mouse–Human Skin Model

2004 • 92 citations

A systematic review of antistreptococcal interventions for guttate and chronic plaque psoriasis

2001 • 90 citations

Novel phenotypes and migratory properties distinguish memory CD4 T cell subsets in lymphoid and lung tissue

2005 • 89 citations

Functional Analysis of the Profilaggrin N-Terminal Peptide: Identification of Domains that Regulate Nuclear and Cytoplasmic Distribution

2002 • 88 citations

Diagnosis of nail psoriasis: importance of biopsy and histopathology

2005 • 86 citations

Keratin 17: a useful marker in anti-psoriatic therapies

1991 • 85 citations

Increased Sensitivity to Interferon-α in Psoriatic T Cells

2005 • 80 citations

Cytokine and Anti-Cytokine Therapies for Psoriasis and Atopic Dermatitis

2006 • 77 citations

Corneodesmosin Expression in Psoriasis Vulgaris Differs from Normal Skin and Other Inflammatory Skin Disorders

2001 • 75 citations

Effects of rIFN Alpha, Beta, and Gamma on the Morphology, Proliferation, and Cell Surface Antigen Expression of Human Dermal Microvascular Endothelial Cells In Vitro

1990 • 75 citations

Immunopathogenesis of Psoriasis

2004 • 75 citations

T lymphocyte co-signaling pathways of the B7-CD28 family.

2004 • 74 citations

Possible relations between the polymorphisms of the cytokines IL-19, IL-20 and IL-24 and plaque-type psoriasis

2005 • 74 citations

Epidermal HLA-DR and the enhancement of cutaneous reactivity to superantigenic toxins in psoriasis

1999 • 72 citations

Immunohistochemical identification of type II alternatively activated dendritic macrophages (RM 3/1+++, MS-1± 25F9−) in psoriatic dermis

1996 • 71 citations

Combined haplotype analysis of the interleukin-19 and -20 genes: relationship to plaque-type psoriasis

2004 • 68 citations

Asparaginyl endopeptidase: case history of a class II MHC compartment protease

2005 • 67 citations

Identification and Cloning of a New Calmodulin-like Protein from Human Epidermis

2000 • 66 citations

A role for CCR4 in development of mature circulating cutaneous T helper memory cell populations

2005 • 64 citations

Pan-selectin antagonism improves psoriasis manifestation in mice and man

2005 • 60 citations

Up-Regulation of Keratin 17 Expression in Human HaCaT Keratinocytes by Interferon-γ

1995 • 59 citations

Treatment of Psoriasis in Children: Is There a Role for Antibiotic Therapy and Tonsillectomy?

2003 • 59 citations

Increased Neutrophil Adherence in Psoriasis: Role of the Human Endothelial Cell Receptor Thy-1 (CD90)

2005 • 58 citations

Homing receptor and chemokine receptor on intraepidermal T cells in psoriasis vulgaris

2004 • 58 citations

Epithelium-lining macrophages in psoriasis

1994 • 55 citations

Pathophysiology of Psoriasis

1977 • 55 citations

Dynamic Differentiation of Activated Human Peripheral Blood CD8+ and CD4+ Effector Memory T Cells

2005 • 54 citations

Keratinocytes as targets for interleukin-10-related cytokines: a putative role in the pathogenesis of psoriasis.

2005 • 53 citations

Cytokine-Induced Expression of Transforming Growth Factor-α and the Epidermal Growth Factor Receptor in Neonatal Skin Explants

1992 • 50 citations

Human Leukocyte Elastase Induces Keratinocyte Proliferation In Vitro and In Vivo

2002 • 50 citations

Chemokines stimulate human T lymphocyte transendothelial migration to utilize VLA-4 in addition to LFA-1

2001 • 49 citations

The expression of legumain, an asparaginyl endopeptidase that controls antigen processing, is reduced in endotoxin-tolerant monocytes

2005 • 49 citations

Expression of nerve growth factor receptors in cutaneous inflammation

1998 • 48 citations

Selective enhancement of multipotential hematopoietic progenitors in vitro and in vivo by IL-20

2003 • 47 citations

Skin CD4+ T Cells Produce Interferon-γIn Vitro in Response to Streptococcal Antigens in Chronic Plaque Psoriasis

2000 • 47 citations

Psoriatic keratinocytes show reduced IRF‐1 and STAT‐1α activation in response to γ‐IFN

1999 • 42 citations

Disease mimicry—a pathogenetic concept for T cell-mediated autoimmune disorders triggered by molecular mimicry?

2003 • 41 citations

Preferential expression of alphaEbeta7 integrin (CD103) on CD8+ T cells in the psoriatic epidermis: regulation by interleukins 4 and 12 and transforming growth factor-beta

2002 • 38 citations

Psoriasis scales contain C5a as the predominant chemotaxin for monocyte‐derived dendritic cells

2001 • 33 citations

The evaluation of psoriasis therapy with biologics leads to a revision of the current view of the pathogenesis of this disorder

2006 • 29 citations

Profilaggrin Requires both Linker and Filaggrin Peptide Sequences to Form Granules: Implications for Profilaggrin Processing In Vivo11This work was presented in part at the Society of Investigative Dermatology meeting in 1997.

1999 • 29 citations

Psoriasis as a T cell-mediated autoimmune disease.

1998 • 27 citations

Incidental detection of S. pyogenes-DNA in psoriatic skin by PCR

2005 • 26 citations

A comparison of the stimulatory effects of cytokines on normal and psoriatic keratinocytes in vitro

1995 • 26 citations

Interferon-γ-Dependent in vitro Model for the Putative Keratin 17 Autoimmune Loop in Psoriasis: Exploration of Pharmaco- and Gene-Therapeutic Effects

2004 • 25 citations

Increased Production of Transforming Growth Factor‐α in Psoriatic Epidermis

1991 • 23 citations

Targeting leukocyte trafficking to inflamed skin – still an attractive therapeutic approach?

2006 • 23 citations

T Cell Phenotypes of the Normal Nasal Mucosa: Induction of Th2 Cytokines and CCR3 Expression by IL-4

2001 • 18 citations

Augmentation of CTLA-4 expression by wortmannin: involvement of lysosomal sorting properties of CTLA-4

1999 • 17 citations

Changes in T‐cell phenotype and adhesion molecules expression in psoriatic lesions after low‐dose cyclosporin therapy

1996 • 17 citations

Normal response to tumor necrosis factor‐alpha and transforming growth factor‐beta by keratinocytes in psoriasis

1993 • 15 citations

Cutaneous biology of gammadelta T cells.

2004 • 9 citations

Psoriasis

1977 • 6 citations