Increased Glomerular and Tubular Expression of Transforming Growth Factor-β1, Its Type II Receptor, and Activation of the Smad Signaling Pathway in the db/db Mouse

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system

2000 • 1,935 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

1992 • 1,071 citations

Transcriptional Activators of TGF-β Responses: Smads

1998 • 1,024 citations

Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

1998 • 916 citations

Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-β antibody indb/dbdiabetic mice

2000 • 907 citations

Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy.

1993 • 819 citations

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription

1998 • 789 citations

Neutralization of TGF-β by Anti-TGF-β Antibody Attenuates Kidney Hypertrophy and the Enhanced Extracellular Matrix Gene Expression in STZ-Induced Diabetic Mice

1996 • 658 citations

Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-beta.

1994 • 593 citations

Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC β inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes

2000 • 425 citations

Expression of transforming growth factor-β isoforms in human glomerular diseases

1996 • 424 citations

ATF-2 Is a Common Nuclear Target of Smad and TAK1 Pathways in Transforming Growth Factor-β Signaling

1999 • 347 citations

Elevated glucose stimulates TGF-β gene expression and bioactivity in proximal tubule

1992 • 264 citations

Expression of transforming growth factor-β1 during diabetic renal hypertrophy

1994 • 237 citations

Suppression of transforming growth factor beta and vascular endothelial growth factor in diabetic nephropathy in rats by a novel advanced glycation end product inhibitor, OPB-9195

1999 • 213 citations

Renal hypertrophy is associated with upregulation of TGF-beta 1 gene expression in diabetic BB rat and NOD mouse

1994 • 186 citations

Quantification of glomerular TGF-β1 mRNA in patients with diabetes mellitus

1996 • 182 citations

Interaction of Smad3 with a proximal smad-binding element of the human ?2(I) procollagen gene promoter required for transcriptional activation by TGF-?

2000 • 180 citations

Expression of Transforming Growth Factor-β and Type IV Collagen in Early Streptozotocin-Induced Diabetes

1997 • 180 citations

Transcriptional activation of transforming growth factor-β1 in mesangial cell culture by high glucose concentration

1998 • 167 citations

Prevention of diabetic nephropathy in db/db mice with glycated albumin antagonists. A novel treatment strategy.

1995 • 150 citations

The transforming growth factor-βbgr/SMAD signaling pathway is present and functional in human mesangial cells

1999 • 144 citations

High Glucose Stimulates Proliferation and Collagen Type I Synthesis in Renal Cortical Fibroblasts

1999 • 143 citations

Extracellular Signal-Regulated Kinase Mediates Stimulation of TGF-β1 and Matrix by High Glucose in Mesangial Cells

2000 • 122 citations

Biochemical events and cytokine interactions linking glucose metabolism to the development of diabetic nephropathy.

1997 • 114 citations

Studies in the diabetic mutant mouse. VI. Evolution of glomerular lesions and associated proteinuria.

1972 • 111 citations

TGF-β receptor expression and binding in rat mesangial cells: Modulation by glucose and cyclic mechanical strain

1999 • 79 citations

Stimulation of TGF-β type II receptor by high glucose in mouse mesangial cells and in diabetic kidney

2000 • 73 citations

Effects of high glucose on the production of heparan sulfate proteoglycan by mesangial and epithelial cells

1996 • 65 citations

In situ non-radioactive detection of nuclear factors in paraffin sections by Southwestern histochemistry

1999 • 64 citations

Captopril reverses high-glucose-induced growth effects on LLC-PK1 cells partly by decreasing transforming growth factor-beta receptor protein expressions.

1996 • 49 citations

The Renal TGF-β System in the db/db Mouse Model of Diabetic Nephropathy

1998 • 43 citations

Early immunopathologic events in experimental diabetic nephropathy: A study in mice

1980 • 25 citations

Role of insulin and IGF1 receptors in proliferation of cultured renal proximal tubule cells

1992 • 24 citations

Hormones, Autacoids, and the Kidney

1992 • 17 citations

In situ DNA-protein binding: A novel method for detecting DNA-binding activity of transcription factor in brain

1992 • 15 citations