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The role of γ-scintigraphy in oral drug delivery

Data up to Jan 2025

Published2001
Citations205
References134

Total Citations Per Year

Abstract

References (134)

Physiology of the Gastrointestinal Tract

2006 • 4,704 citations

Physiology of the Gastrointestinal Tract.

1982 • 1,635 citations

Measurement of gastrointestinal pH profiles in normal ambulant human subjects.

1988 • 1,146 citations

A migrating electric complex of canine small intestine

1969 • 864 citations

Percutaneous endoscopic gastrostomy

1987 • 860 citations

Transit of pharmaceutical dosage forms through the small intestine.

1986 • 849 citations

Bioadhesive polymers as platforms for oral-controlled drug delivery: method to study bioadhesion

1984 • 427 citations

MEASUREMENT OF RATE OF GASTRIC EMPTYING USING CHROMIUM-51

1966 • 361 citations

Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects.

1991 • 265 citations

Topics in Pharmaceutical Sciences

1982 • 264 citations

Controlled-Release Multiple-Units and Single-Unit Doses a Literature Review

1978 • 240 citations

Topics in Pharmaceutical Sciences

1983 • 226 citations

The effect of density on the gastric emptying of single- and multiple-unit dosage forms.

1986 • 226 citations

The Hydrodynamically Balanced System (Hbs™): A Novel Drug Delivery System for Oral Use

1984 • 214 citations

A comparative study of the gastrointestinal transit of a pellet and tablet formulation

1984 • 211 citations

Drug delivery to the proximal colon

1985 • 176 citations

Techniques and errors in scintigraphic measurements of gastric emptying.

1978 • 168 citations

Distribution of pellets in the gastrointestinal tract. The influence on transit time exerted by the density or diameter of pellets

1978 • 159 citations

Instrumentation in Nuclear Medicine

1967 • 156 citations

Gastrointestinal transit of non-disintegrating tablets in fed subjects

1989 • 142 citations

Effect of Certain Tablet Formulation Factors on Dissolution Rate of the Active Ingredient I11

1963 • 136 citations

The effect of food on the gastrointestinal transit of pellets and an osmotic device (Osmet)

1984 • 136 citations

Effects of gender, posture, and age on gastric residence time of an indigestible solid: pharmaceutical considerations.

1988 • 120 citations

Bioadhesion — Possibilities and future trends

1991 • 117 citations

An Illustrated Guide to Gastrointestinal Motility

1989 • 115 citations

Evaluation of the effect of food and specific gravity of tablets on gastric retention time

1987 • 114 citations

Estimation of gastric residence time of the heidelberg capsule in humans: Effect of varying food composition

1985 • 110 citations

Use of 99mTc-DTPA for measuring gastric emptying time.

1974 • 109 citations

The effect of polycarbophil on the gastric emptying of pellets

1987 • 107 citations

The design and evaluation of controlled release systems for the gastrointestinal tract

1985 • 107 citations

Gastroenterologic endoscopy

1988 • 106 citations

Conception and in vivo investigation of peroral sustained release floating dosage forms with enhanced gastrointestinal transit

1987 • 104 citations

Motility of the ileocolonic junction.

1988 • 101 citations

Gastrointestinal transit and systemic absorption of captopril from a pulsed-release formulation.

1992 • 101 citations

The influence of density on the gastrointestinal transit of pellets

1990 • 100 citations

Emptying of the terminal ileum in intact humans

1987 • 98 citations

Evaluation of an enteric‐coated delayed‐release 5‐aminosalicylic acid tablet in patients with inflammatory bowel disease

1987 • 98 citations

Effect of Certain Tablet Formulation Factors on Dissolution Rate of the Active Ingredient I

1963 • 95 citations

GI transit of potential bioadhesive formulations in man: A scintigraphic study

1990 • 93 citations

Method for Monitoring Hard Gelatin Capsule Disintegration Times in Humans Using External Scintigraphy

1976 • 93 citations

ROYAL SOCIETY OF MEDICINE

1949 • 91 citations

Bimodal release of ibuprofen in a sustained-release formulation: a scintigraphic and pharmacokinetic open study in healthy volunteers under different conditions of food intake

1989 • 88 citations

The behaviour of a fast-dissolving dosage form (Expidet) followed by γ-scintigraphy

1987 • 80 citations

Correlation of the gastric emptying of nondisintegrating tablets with gastrointestinal motility.

1991 • 77 citations

The effect of tablet size on the gastric emptying of non-disintegrating tablets

1990 • 76 citations

Gastrointestinal transit of a controlled-release pellet formulation of tiaprofenic acid and the effect of food

1987 • 74 citations

Gastrointestinal transit of a solid indigestible capsule as measured by radiotelemetry and dual gamma scintigraphy.

1989 • 74 citations

The in-vivo evaluation of an osmotic device (Osmet) using gamma scintigraphy

1984 • 69 citations

Gastrointestinal motility: which test?

1990 • 69 citations

Gastrointestinal transit of an enteric‐coated delayed‐release 5‐aminosalicylic acid tablet

1987 • 67 citations

The influence of food on the gastric emptying of multiparticulate dosage forms

1987 • 66 citations

In vivo evaluation of rapid release and sustained release Gelucire capsule formulations

1990 • 64 citations

Gastrointestinal Behavior of Orally Administered Radiolabeled Erythromycin Pellets in Man as Determined by Gamma Scintigraphy

1990 • 64 citations

Gastric emptying and small and large bowel transit of non-disintegrating tablets in fasted subjects

1989 • 63 citations

On the intestinal transit of a single non-disintegrating object

1984 • 62 citations

Gastric emptying of large single unit dosage forms

1988 • 61 citations

OBSTETRIC ULTRASOUND AND CHILDHOOD MALIGNANCIES

1984 • 59 citations

Gastrointestinal transit of small tablets in patients with ulcerative colitis

1988 • 58 citations

Premedication for upper gastrointestinal endoscopy

1989 • 57 citations

Heterogeneous Catalysis

1983 • 57 citations

Correlation of ibuprofen bioavailability with gastrointestinal transit by scintigraphic monitoring of 171Er-labeled sustained-release tablets.

1987 • 52 citations

An illustrated guide to gastrointestinal motility

1989 • 50 citations

Gastric emptying of enteric-coated tablets

1984 • 50 citations

A comparative evaluation of techniques for rapid and efficient in vivo labeling of red cells with [99mTc] pertechnetate.

1977 • 49 citations

The Gastric Emptying of Pellets Contained in Hard Gelatin Capsules

1982 • 46 citations

Evaluation of an enteric coated naproxen tablet using gamma scintigraphy and pH monitoring

1987 • 46 citations

Scintigraphic assessment of the in vivo dissolution rate of a sustained release tablet

1982 • 45 citations

Pharmacokinetics: A Modern View

1984 • 44 citations

Transpyloric fluid movement and antroduodenal motility in patients with gastro-oesophageal reflux.

1987 • 43 citations

Characterisation of the In Vivo Behaviour of a Controlled-Release Formulation of Levodopa (Sinemet CR)

1991 • 42 citations

Pharmacokinetics and in vivo scintigraphic monitoring of a sustained release acetylsalicylic acid formulation

1984 • 42 citations

Relationship between the rate of appearance of oxprenolol in the systemic circulation and the location of an oxprenolol Oros 16/260 drug delivery system within the gastrointestinal tract as determined by scintigraphy.

1988 • 42 citations

Mechanism of gastric emptying of a nondisintegrating radiotelemetry capsule in man.

1991 • 40 citations

Relationship between systemic drug absorption and gastrointestinal transit after the simultaneous oral administration of carbamazepine as a controlled‐release system and as a suspension of 15N‐labelled drug to healthy volunteers.

1991 • 39 citations

Investigation of the gastrointestinal transit and in vivo drug release of isosorbide-5-nitrate pellets.

1987 • 39 citations

‘In vivo’ disintegration of hard gelatin capsules in fasting and non-fasting subjects

1980 • 37 citations

Gastrointestinal Transit and Concomitant Absorption of Verapamil from a Single-Unit Sustained-Release Tablet

1987 • 34 citations

The effect of food on gastrointestinal (GI) transit of sustained-release ibuprofen tablets as evaluated by gamma scintigraphy.

1990 • 33 citations

Gastrointestinal transit of a multiparticulate tablet formulation in patients with active ulcerative colitis

1991 • 32 citations

Evaluation of an enteric‐coated naproxen pellet formulation

1991 • 31 citations

A gamma scintigraphic study to compare oesophageal clearance of “Expidet” formulations, tablets and capsules in supine volunteers

1988 • 31 citations

Method for Determining In Vivo Tablet Disintegration

1965 • 30 citations

Gastrointestinal transit of a controlled release naproxen tablet formulation

1986 • 30 citations

A gastroscopic and pharmacological study of the disintegration time and absorption of pivampicillin capsules and tablets.

1979 • 29 citations

The effect of capsule size and density on transit through the proximal colon

1988 • 29 citations

Radiolabeling of Intact Tablets by Neutron Activation for In Vivo Scintigraphic Studies

1985 • 29 citations

Application of radiotelemetric technique in evaluating diclofenac sodium absorption after oral administration of various dosage forms in healthy volunteers.

1990 • 28 citations

Rate and pattern of gastric emptying in humans using 99mTc-Labeled triethylenetetraamine–polystyrene resin

1980 • 27 citations

Correlation of phenylpropanolamine bioavailability with gastrointestinal transit by scintigraphic monitoring of 111In-labeled hydroxypropylmethylcellulose matrices.

1989 • 27 citations

The effect of food on gastrointestinal transit and drug absorption of a multiparticular sustained-release verapamil formulation

1989 • 27 citations

Gastrointestinal Transit and Release of Mesalazine Tablets in Patients with Inflammatory Bowel Disease

1990 • 26 citations

The effect of sleep on the gastrointestinal transit of pharmaceutical dosage forms

1992 • 26 citations

Exercise and small intestinal transit

1987 • 25 citations

THE ABILITY OF PATIENTS TO SWALLOW CAPSULES

1981 • 24 citations

What Happens to Tablets and Capsules in the Stomach: Endoscopic Comparison of Disintegration and Dispersion Characteristics of Two Microencapsulated Potassium Formulations

1990 • 24 citations

A profile scanning method of studying the release properties of different types of tablets in man.

1976 • 23 citations

[Gastric evacuation time following a standard meal as determined by radio-opaque granules. Clinical applications and validation (author's transl)].

1980 • 23 citations

The effect of in-vivo dispersion and gastric emptying on glibenclamide absorption from a novel, rapidly dissolving capsule formulation

1984 • 22 citations

Influence of single and multiple doses of oral ranitidine on the gastric transit of an indigestible capsule in humans

1990 • 22 citations

The influence of food on the absorption of acyclovir: a pharmacokinetic and scintigraphic assessment

1987 • 21 citations

The effect of fibre on gastrointestinal transit times in vegetarians and omnivores

1991 • 21 citations

Gastrointestinal motility : which test?

1989 • 20 citations

Gastrointestinal transit of an osmotic tablet drug delivery system

1985 • 20 citations

Basic science of nuclear medicine

1978 • 19 citations

The gastrointestinal transit of a controlled release formulation of indomethacin

1990 • 19 citations

Dissolution rate and transit times of technetium-99m DTPA-labeled tablets.

1987 • 18 citations

The effect of eating on transit through the small intestine

1989 • 18 citations

Radiolabeling of an enteric coated tablet by (n,γ) radioactivation of erbium-170 for scintigraphic imaging

1986 • 17 citations

Deposition of a model substance, 99m Tc E-HIDA, in the oral cavity after administration of lozenges, chewing gum and sublingual tablets

1990 • 16 citations

EFFECT OF STRESS ON THE GASTRIC EMPTYING OF CAPSULES

1984 • 16 citations

Gastrointestinal transit time of single-unit tablets

1981 • 16 citations

Textbook of Nuclear Medicine Technology.

1970 • 14 citations

Gastroscopic and pharmacokinetic evaluation of a new pivmecillinam tablet

1982 • 14 citations

Stabilization of particulate suspensions with nonantigenic polyhydric alcohols: application to 99mTc-sulfur colloid.

1969 • 14 citations

Gastrointestinal transit of Sinemet CR in healthy volunteers.

1989 • 14 citations

The gastrointestinal transit investigation of a controlled release aminophylline formulation

1989 • 13 citations

Radiolabeling of intact dosage forms by neutron activation: effects on in vitro performance.

1987 • 12 citations

[Comparative study of gastric emptying of digestible and nondigestible solids in normal man and duodenal ulcer patients].

1983 • 11 citations

Oesophageal transit of small tablets

1988 • 11 citations

A comparison of the behaviour of tablet and capsule formulations in vivo

1981 • 10 citations

Delivery of drugs to the colon by means of a new microencapsulated oral dosage form.

1983 • 9 citations

Plasma concentrations of remoxipride and the gastrointestinal transit of 111In-marked extended-release coated spheres.

1990 • 9 citations

Scintigraphic study of the gastro-intestinal transit and correlations with the drug absorption kinetics of a sustained release theophylline tablet

1988 • 8 citations

Gastrointestinal scintigraphy with 99mTc-DTPA labeled tablets in fed and fasting subjects

1989 • 8 citations

Role of Rectal Formulations: Enemas

1990 • 7 citations

The Gastric Emptying of Pellets in Supine Volunteers

1986 • 6 citations

A Direct Method for Studying the Efficiency of “Enteric” Tablets

1933 • 5 citations

[Development and pharmacokinetic study of metoprolol tartrate controlled-release tablet remaining-floating in stomach].

1989 • 5 citations

Therapeutic Upper Gastrointestinal Endoscopy : Past, Present, and Future

1990 • 4 citations

LACTOSE-BARIUM SMALL BOWEL STUDY

1971 • 3 citations

Representation of the path of a non-disintegrating capsule in the gastrointestinal tract using external scintigraphy and computer graphics

1986 • 3 citations

LACTOSE-BARIUM SMALL BOWEL STUDY

1972 • 3 citations

Modern Pharmaceutical Dosage Forms

1984 • 1 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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The role of γ-scintigraphy in oral drug delivery (2001) – Advanced Drug Delivery Reviews | Metascience Observatory Explorer