The role of γ-scintigraphy in oral drug delivery
Data up to Jan 2025
Total Citations Per Year
Abstract
References (134)
Physiology of the Gastrointestinal Tract
2006 • 4,704 citations
Physiology of the Gastrointestinal Tract.
1982 • 1,635 citations
Measurement of gastrointestinal pH profiles in normal ambulant human subjects.
1988 • 1,146 citations
A migrating electric complex of canine small intestine
1969 • 864 citations
Percutaneous endoscopic gastrostomy
1987 • 860 citations
Transit of pharmaceutical dosage forms through the small intestine.
1986 • 849 citations
Bioadhesive polymers as platforms for oral-controlled drug delivery: method to study bioadhesion
1984 • 427 citations
MEASUREMENT OF RATE OF GASTRIC EMPTYING USING CHROMIUM-51
1966 • 361 citations
Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects.
1991 • 265 citations
Topics in Pharmaceutical Sciences
1982 • 264 citations
Controlled-Release Multiple-Units and Single-Unit Doses a Literature Review
1978 • 240 citations
Topics in Pharmaceutical Sciences
1983 • 226 citations
The effect of density on the gastric emptying of single- and multiple-unit dosage forms.
1986 • 226 citations
The Hydrodynamically Balanced System (Hbs™): A Novel Drug Delivery System for Oral Use
1984 • 214 citations
A comparative study of the gastrointestinal transit of a pellet and tablet formulation
1984 • 211 citations
Drug delivery to the proximal colon
1985 • 176 citations
Techniques and errors in scintigraphic measurements of gastric emptying.
1978 • 168 citations
Distribution of pellets in the gastrointestinal tract. The influence on transit time exerted by the density or diameter of pellets
1978 • 159 citations
Instrumentation in Nuclear Medicine
1967 • 156 citations
Gastrointestinal transit of non-disintegrating tablets in fed subjects
1989 • 142 citations
Effect of Certain Tablet Formulation Factors on Dissolution Rate of the Active Ingredient I11
1963 • 136 citations
The effect of food on the gastrointestinal transit of pellets and an osmotic device (Osmet)
1984 • 136 citations
Effects of gender, posture, and age on gastric residence time of an indigestible solid: pharmaceutical considerations.
1988 • 120 citations
Bioadhesion — Possibilities and future trends
1991 • 117 citations
An Illustrated Guide to Gastrointestinal Motility
1989 • 115 citations
Evaluation of the effect of food and specific gravity of tablets on gastric retention time
1987 • 114 citations
Estimation of gastric residence time of the heidelberg capsule in humans: Effect of varying food composition
1985 • 110 citations
Use of 99mTc-DTPA for measuring gastric emptying time.
1974 • 109 citations
The effect of polycarbophil on the gastric emptying of pellets
1987 • 107 citations
The design and evaluation of controlled release systems for the gastrointestinal tract
1985 • 107 citations
Gastroenterologic endoscopy
1988 • 106 citations
Conception and in vivo investigation of peroral sustained release floating dosage forms with enhanced gastrointestinal transit
1987 • 104 citations
Motility of the ileocolonic junction.
1988 • 101 citations
Gastrointestinal transit and systemic absorption of captopril from a pulsed-release formulation.
1992 • 101 citations
The influence of density on the gastrointestinal transit of pellets
1990 • 100 citations
Emptying of the terminal ileum in intact humans
1987 • 98 citations
Evaluation of an enteric‐coated delayed‐release 5‐aminosalicylic acid tablet in patients with inflammatory bowel disease
1987 • 98 citations
Effect of Certain Tablet Formulation Factors on Dissolution Rate of the Active Ingredient I
1963 • 95 citations
GI transit of potential bioadhesive formulations in man: A scintigraphic study
1990 • 93 citations
Method for Monitoring Hard Gelatin Capsule Disintegration Times in Humans Using External Scintigraphy
1976 • 93 citations
ROYAL SOCIETY OF MEDICINE
1949 • 91 citations
Bimodal release of ibuprofen in a sustained-release formulation: a scintigraphic and pharmacokinetic open study in healthy volunteers under different conditions of food intake
1989 • 88 citations
The behaviour of a fast-dissolving dosage form (Expidet) followed by γ-scintigraphy
1987 • 80 citations
Correlation of the gastric emptying of nondisintegrating tablets with gastrointestinal motility.
1991 • 77 citations
The effect of tablet size on the gastric emptying of non-disintegrating tablets
1990 • 76 citations
Gastrointestinal transit of a controlled-release pellet formulation of tiaprofenic acid and the effect of food
1987 • 74 citations
Gastrointestinal transit of a solid indigestible capsule as measured by radiotelemetry and dual gamma scintigraphy.
1989 • 74 citations
The in-vivo evaluation of an osmotic device (Osmet) using gamma scintigraphy
1984 • 69 citations
Gastrointestinal motility: which test?
1990 • 69 citations
Gastrointestinal transit of an enteric‐coated delayed‐release 5‐aminosalicylic acid tablet
1987 • 67 citations
The influence of food on the gastric emptying of multiparticulate dosage forms
1987 • 66 citations
In vivo evaluation of rapid release and sustained release Gelucire capsule formulations
1990 • 64 citations
Gastrointestinal Behavior of Orally Administered Radiolabeled Erythromycin Pellets in Man as Determined by Gamma Scintigraphy
1990 • 64 citations
Gastric emptying and small and large bowel transit of non-disintegrating tablets in fasted subjects
1989 • 63 citations
On the intestinal transit of a single non-disintegrating object
1984 • 62 citations
Gastric emptying of large single unit dosage forms
1988 • 61 citations
OBSTETRIC ULTRASOUND AND CHILDHOOD MALIGNANCIES
1984 • 59 citations
Gastrointestinal transit of small tablets in patients with ulcerative colitis
1988 • 58 citations
Premedication for upper gastrointestinal endoscopy
1989 • 57 citations
Heterogeneous Catalysis
1983 • 57 citations
Correlation of ibuprofen bioavailability with gastrointestinal transit by scintigraphic monitoring of 171Er-labeled sustained-release tablets.
1987 • 52 citations
An illustrated guide to gastrointestinal motility
1989 • 50 citations
Gastric emptying of enteric-coated tablets
1984 • 50 citations
A comparative evaluation of techniques for rapid and efficient in vivo labeling of red cells with [99mTc] pertechnetate.
1977 • 49 citations
The Gastric Emptying of Pellets Contained in Hard Gelatin Capsules
1982 • 46 citations
Evaluation of an enteric coated naproxen tablet using gamma scintigraphy and pH monitoring
1987 • 46 citations
Scintigraphic assessment of the in vivo dissolution rate of a sustained release tablet
1982 • 45 citations
Pharmacokinetics: A Modern View
1984 • 44 citations
Transpyloric fluid movement and antroduodenal motility in patients with gastro-oesophageal reflux.
1987 • 43 citations
Characterisation of the In Vivo Behaviour of a Controlled-Release Formulation of Levodopa (Sinemet CR)
1991 • 42 citations
Pharmacokinetics and in vivo scintigraphic monitoring of a sustained release acetylsalicylic acid formulation
1984 • 42 citations
Relationship between the rate of appearance of oxprenolol in the systemic circulation and the location of an oxprenolol Oros 16/260 drug delivery system within the gastrointestinal tract as determined by scintigraphy.
1988 • 42 citations
Mechanism of gastric emptying of a nondisintegrating radiotelemetry capsule in man.
1991 • 40 citations
Relationship between systemic drug absorption and gastrointestinal transit after the simultaneous oral administration of carbamazepine as a controlled‐release system and as a suspension of 15N‐labelled drug to healthy volunteers.
1991 • 39 citations
Investigation of the gastrointestinal transit and in vivo drug release of isosorbide-5-nitrate pellets.
1987 • 39 citations
‘In vivo’ disintegration of hard gelatin capsules in fasting and non-fasting subjects
1980 • 37 citations
Gastrointestinal Transit and Concomitant Absorption of Verapamil from a Single-Unit Sustained-Release Tablet
1987 • 34 citations
The effect of food on gastrointestinal (GI) transit of sustained-release ibuprofen tablets as evaluated by gamma scintigraphy.
1990 • 33 citations
Gastrointestinal transit of a multiparticulate tablet formulation in patients with active ulcerative colitis
1991 • 32 citations
Evaluation of an enteric‐coated naproxen pellet formulation
1991 • 31 citations
A gamma scintigraphic study to compare oesophageal clearance of “Expidet” formulations, tablets and capsules in supine volunteers
1988 • 31 citations
Method for Determining In Vivo Tablet Disintegration
1965 • 30 citations
Gastrointestinal transit of a controlled release naproxen tablet formulation
1986 • 30 citations
A gastroscopic and pharmacological study of the disintegration time and absorption of pivampicillin capsules and tablets.
1979 • 29 citations
The effect of capsule size and density on transit through the proximal colon
1988 • 29 citations
Radiolabeling of Intact Tablets by Neutron Activation for In Vivo Scintigraphic Studies
1985 • 29 citations
Application of radiotelemetric technique in evaluating diclofenac sodium absorption after oral administration of various dosage forms in healthy volunteers.
1990 • 28 citations
Rate and pattern of gastric emptying in humans using 99mTc-Labeled triethylenetetraamine–polystyrene resin
1980 • 27 citations
Correlation of phenylpropanolamine bioavailability with gastrointestinal transit by scintigraphic monitoring of 111In-labeled hydroxypropylmethylcellulose matrices.
1989 • 27 citations
The effect of food on gastrointestinal transit and drug absorption of a multiparticular sustained-release verapamil formulation
1989 • 27 citations
Gastrointestinal Transit and Release of Mesalazine Tablets in Patients with Inflammatory Bowel Disease
1990 • 26 citations
The effect of sleep on the gastrointestinal transit of pharmaceutical dosage forms
1992 • 26 citations
Exercise and small intestinal transit
1987 • 25 citations
THE ABILITY OF PATIENTS TO SWALLOW CAPSULES
1981 • 24 citations
What Happens to Tablets and Capsules in the Stomach: Endoscopic Comparison of Disintegration and Dispersion Characteristics of Two Microencapsulated Potassium Formulations
1990 • 24 citations
A profile scanning method of studying the release properties of different types of tablets in man.
1976 • 23 citations
[Gastric evacuation time following a standard meal as determined by radio-opaque granules. Clinical applications and validation (author's transl)].
1980 • 23 citations
The effect of in-vivo dispersion and gastric emptying on glibenclamide absorption from a novel, rapidly dissolving capsule formulation
1984 • 22 citations
Influence of single and multiple doses of oral ranitidine on the gastric transit of an indigestible capsule in humans
1990 • 22 citations
The influence of food on the absorption of acyclovir: a pharmacokinetic and scintigraphic assessment
1987 • 21 citations
The effect of fibre on gastrointestinal transit times in vegetarians and omnivores
1991 • 21 citations
Gastrointestinal motility : which test?
1989 • 20 citations
Gastrointestinal transit of an osmotic tablet drug delivery system
1985 • 20 citations
Basic science of nuclear medicine
1978 • 19 citations
The gastrointestinal transit of a controlled release formulation of indomethacin
1990 • 19 citations
Dissolution rate and transit times of technetium-99m DTPA-labeled tablets.
1987 • 18 citations
The effect of eating on transit through the small intestine
1989 • 18 citations
Radiolabeling of an enteric coated tablet by (n,γ) radioactivation of erbium-170 for scintigraphic imaging
1986 • 17 citations
Deposition of a model substance, 99m Tc E-HIDA, in the oral cavity after administration of lozenges, chewing gum and sublingual tablets
1990 • 16 citations
EFFECT OF STRESS ON THE GASTRIC EMPTYING OF CAPSULES
1984 • 16 citations
Gastrointestinal transit time of single-unit tablets
1981 • 16 citations
Textbook of Nuclear Medicine Technology.
1970 • 14 citations
Gastroscopic and pharmacokinetic evaluation of a new pivmecillinam tablet
1982 • 14 citations
Stabilization of particulate suspensions with nonantigenic polyhydric alcohols: application to 99mTc-sulfur colloid.
1969 • 14 citations
Gastrointestinal transit of Sinemet CR in healthy volunteers.
1989 • 14 citations
The gastrointestinal transit investigation of a controlled release aminophylline formulation
1989 • 13 citations
Radiolabeling of intact dosage forms by neutron activation: effects on in vitro performance.
1987 • 12 citations
[Comparative study of gastric emptying of digestible and nondigestible solids in normal man and duodenal ulcer patients].
1983 • 11 citations
Oesophageal transit of small tablets
1988 • 11 citations
A comparison of the behaviour of tablet and capsule formulations in vivo
1981 • 10 citations
Delivery of drugs to the colon by means of a new microencapsulated oral dosage form.
1983 • 9 citations
Plasma concentrations of remoxipride and the gastrointestinal transit of 111In-marked extended-release coated spheres.
1990 • 9 citations
Scintigraphic study of the gastro-intestinal transit and correlations with the drug absorption kinetics of a sustained release theophylline tablet
1988 • 8 citations
Gastrointestinal scintigraphy with 99mTc-DTPA labeled tablets in fed and fasting subjects
1989 • 8 citations
Role of Rectal Formulations: Enemas
1990 • 7 citations
The Gastric Emptying of Pellets in Supine Volunteers
1986 • 6 citations
A Direct Method for Studying the Efficiency of “Enteric” Tablets
1933 • 5 citations
[Development and pharmacokinetic study of metoprolol tartrate controlled-release tablet remaining-floating in stomach].
1989 • 5 citations
Therapeutic Upper Gastrointestinal Endoscopy : Past, Present, and Future
1990 • 4 citations
LACTOSE-BARIUM SMALL BOWEL STUDY
1971 • 3 citations
Representation of the path of a non-disintegrating capsule in the gastrointestinal tract using external scintigraphy and computer graphics
1986 • 3 citations
LACTOSE-BARIUM SMALL BOWEL STUDY
1972 • 3 citations
Modern Pharmaceutical Dosage Forms
1984 • 1 citations
Deleted Work
1955 • 0 citations