Liver Endocytosis and Kupffer Cells

Coated pits, coated vesicles, and receptor-mediated endocytosis

1979 • 2,073 citations

FIBRONECTIN AND ITS RECEPTORS

1988 • 1,336 citations

Two distinct classes of carbohydrate-recognition domains in animal lectins.

1988 • 1,259 citations

The Role of Surface Carbohydrates in the Hepatic Recognition and Transport of Circulating Glycoproteins

1974 • 1,200 citations

Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis.

1987 • 1,152 citations

Type I macrophage scavenger receptor contains α-helical and collagen-like coiled coils

1990 • 1,039 citations

Biologically active products of stimulated liver macrophages (Kupffer cells)

1990 • 926 citations

Manual of Clinical Laboratory Immunology

1997 • 833 citations

Cells of the hepatic sinusoid

1989 • 589 citations

Increased tumor necrosis factor production by monocytes in alcoholic hepatitis

1989 • 542 citations

Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess

1987 • 539 citations

Enzymes of the Renin-Angiotensin System and their Inhibitors

1982 • 465 citations

Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II

1990 • 460 citations

The Clearance, Tissue Distribution, and Cellular Localization of Intravenously Injected Lipopolysaccharide in Rabbits

1979 • 427 citations

Effects of cytokines on the liver

1991 • 409 citations

The receptosome: An intermediate organelle of receptor-mediated endocytosis in cultured fibroblasts

1980 • 398 citations

In vivo and in vitro uptake and degradation of acetylated low density lipoprotein by rat liver endothelial, Kupffer, and parenchymal cells.

1983 • 396 citations

Quantitation, tissue distribution and proliferation kinetics of kupffer cells in normal rat liver

1986 • 359 citations

An ancient, highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors.

1990 • 311 citations

THE INVOLVEMENT OF LACTOFERRIN IN THE HYPOSIDEREMIA OF ACUTE INFLAMMATION

1974 • 294 citations

Different fate in vivo of oxidatively modified low density lipoprotein and acetylated low density lipoprotein in rats. Recognition by various scavenger receptors on Kupffer and endothelial liver cells

1991 • 275 citations

Neutrophil and monocyte cell surface p150,95 has iC3b-receptor (CR4) activity resembling CR3.

1988 • 266 citations

Purification and characterization of a bovine acetyl low density lipoprotein receptor.

1988 • 259 citations

C-reactive protein is protective against Streptococcus pneumoniae infection in mice.

1981 • 239 citations

IMMUNE COMPLEXES CONTAINING FOOD PROTEINS IN NORMAL AND ATOPIC SUBJECTS AFTER ORAL CHALLENGE AND EFFECT OF SODIUM CROMOGLYCATE ON ANTIGEN ABSORPTION

1979 • 227 citations

The Relation of Leukotrienes to Liver Injury

1985 • 211 citations

Clearance Capacity of Rat Liver Kupffer, Endothelial, and Parenchymal Cells

1981 • 188 citations

Relation between localization and function of rat liver Kupffer cells.

1982 • 184 citations

Insights into the pathogenesis of alcoholic liver necrosis and fibrosis: Status report

1990 • 180 citations

Ueber Sternzellen der Leber

1876 • 178 citations

The liver and IgA: Immunological, cell biological and clinical implications

1989 • 177 citations

Macrophage cytotoxicity: interleukin 1 as a mediator of tumor cytostasis.

1986 • 168 citations

Elimination of ¹²⁵I‐Trypsin α‐Macroglobulin Complexes from Blood by Reticuloendothelial Cells in Dog

1971 • 167 citations

Involvement of tumor necrosis factor-α in development of hepatic injury in galactosamine-sensitized mice

1990 • 159 citations

HYPERGLOBULINÆMIA IN LIVER DISEASE

1973 • 159 citations

Phagocytosis, an unrecognized property of murine endothelial liver cells

1986 • 156 citations

A macrophage receptor for (mannose/glucosamine)-glycoproteins of potential importance in phagocytic activity

1980 • 155 citations

The involvement of parenchymal, Kupffer and endothelial liver cells in the hepatic uptake of intravenously injected liposomes effects of lanthanum and gadolinium salts

1981 • 149 citations

The liver in sickle cell disease

1980 • 145 citations

A quantitative analysis of the interactions of antipneumococcal antibody and complement in experimental pneumococcal bacteremia.

1982 • 144 citations

Study of reticuloendothelial phagocytic capacity in patients with cholestasis.

1976 • 138 citations

Interactions between isolated hepatocytes and kupffer cells in iron metabolism: A possible role for ferritin as an iron carrier protein

1988 • 134 citations

Iron metabolism in the erythrophagocytosing Kupffer cell

1988 • 124 citations

Comparative Study of Cytotoxicity, Tumor Necrosis Factor, and Prostaglandin Release After Stimulation of Rat Kupffer Cells, Murine Kupffer Cells, and Murine Inflammatory Liver Macrophages

1989 • 123 citations

Modulation of hepatotoxicity by macrophages in the liver

1988 • 123 citations

Binding of Escherichia coli and Salmonella strains to members of the carcinoembryonic antigen family: differential binding inhibition by aromatic alpha-glycosides of mannose

1991 • 116 citations

Low-molecular weight C1q-binding immunoglobulin G in patients with systemic lupus erythematosus consists of autoantibodies to the collagen-like region of C1q.

1988 • 115 citations

Impaired Bacterial Clearance and Trapping in Obstructive Jaundice

1984 • 112 citations

Binding and complement activation by C-reactive protein via the collagen-like region of C1q and inhibition of these reactions by monoclonal antibodies to C-reactive protein and C1q.

1991 • 112 citations

The Pathway of Endocytosis

1985 • 112 citations

Recognition of lysosomal glycosidases in vivo inhibited by modified glycoproteins

1976 • 102 citations

Molecular cloning and sequencing of a cDNA for a carbohydrate binding receptor unique to rat Kupffer cells.

1988 • 102 citations

Effect of DNA size and strandedness on the in vivo clearance and organ localization of DNA.

1984 • 98 citations

Clathrin and coated vesicles.

1987 • 95 citations

Identification and quantitation of platelet-associated fibronectin antigen.

1979 • 95 citations

Binding of tissue-type plasminogen activator by the mannose receptor

1991 • 94 citations

Role of the Kupffer cells in local and systemic immune responses

1981 • 92 citations

Differential properties of organ-specific serum opsonins for liver and spleen macrophages

1989 • 91 citations

Role of the liver in clearance and excretion of circulating carcinoembryonic antigen (CEA)

1983 • 87 citations

Kupffer cell blockade inhibits induction of tolerance by the portal venous route.

1989 • 87 citations

Molecular cloning of a gene belonging to the carcinoembryonic antigen gene family and discussion of a domain model.

1987 • 86 citations

KUPFFER CELL BLOCKADE INHIBITS INDUCTION OF TOLERANCE BY THE PORTAL VENOUS ROUTE

1989 • 85 citations

Peliosis hepatis and sinusoidal dilation during infection by the human immunodeficiency virus (HIV). An ultrastructural study.

1988 • 84 citations

BACTERIAL INFECTION AND THE ASPLENIC HOST

1976 • 83 citations

Clearance of circulating IgA immune complexes is mediated by a specific receptor on Kupffer cells in mice.

1984 • 82 citations

Comparative studies of endotoxin uptake by isolated rat Kupffer and peritoneal cells

1987 • 81 citations

Receptor-Mediated Clearance of Aspergillus Galactomannan

1987 • 79 citations

Endocytosis via galactose receptors in vivo

1986 • 78 citations

Liver sinusoidal lining cells express class II major histocompatibility antigens but are poor stimulators of fresh allogeneic T lymphocytes.

1986 • 78 citations

Liver endothelium and not hepatocytes or Kupffer cells have transferrin receptors

1984 • 77 citations

Analysis of lectin-dependent recognition of desialylated erythrocytes by Kupffer cells

1980 • 77 citations

Studies in vivo and in vitro on the uptake and degradation of soluble collagen α1(I) chains in rat liver endothelial and Kupffer cells

1985 • 77 citations

Endotoxic-lipopolysaccharide-specific binding proteins on lymphoid cells of various animal species: association with endotoxin susceptibility

1989 • 72 citations

Products of lipopolysaccharide-activated macrophages (tumor necrosis factor-alpha, transforming growth factor-beta) but not lipopolysaccharide modify DNA synthesis by rat trophoblast cells exhibiting the 80-kDa lipopolysaccharide-binding protein.

1989 • 72 citations

Reticulo-endothelial function in obstructive jaundice

1987 • 72 citations

Receptor-mediated endocytosis of carcinoembryonic antigen by rat liver Kupffer cells.

1985 • 70 citations

Antigen presentation by isolated guinea pig Kupffer cells.

1980 • 70 citations

Both macrophages and endothelial cells of the human hepatic sinusoid express the CD4 molecule, a receptor for the human immunodeficiency virus

1990 • 68 citations

Fluid endocytosis by rat liver and spleen. Experiments with 125I-labelled poly(vinylpyrrolidone) in vivo

1980 • 68 citations

Blood clearance of Streptococcus pneumoniae by C-reactive protein.

1987 • 68 citations

Interaction of human plasma fibronectin with cariogenic and non-cariogenic oral streptococci

1983 • 67 citations

Proteolytic enzymes released by liver macrophages may promote hepatic injury in a rat model of hepatic damage.

1981 • 65 citations

The plasma clearance of human α2-macroglobulin-trypsin complex in the rat is mainly accounted for by uptake into hepatocytes

1985 • 64 citations

In vivo fate of large unilamellar sphingomyelin-cholesterol liposomes after intraperitoneal and intravenous injection into rats

1981 • 63 citations

Antigen presentation by liver sinusoidal lining cells after antigen exposure in vivo.

1987 • 61 citations

Rat liver endothelial cells have a greater capacity than kupffer cells to endocytoseN-acetylglucosamine- and mannose-terminated glycoproteins

1987 • 60 citations

The ligand binding specificity and tissue localization of a rat alveolar macrophage lectin.

1986 • 58 citations

Kupffer cells and liver metastasis

1989 • 58 citations

Proteolytic enzymes released by liver macrophages may promote hepatic injury in a rat model of hepatic damage

1981 • 57 citations

Antibody-independent interactions between Escherichia coli J5 and human complement components.

1981 • 57 citations

Receptor-mediated endocytosis of lactate dehydrogenase M4 by liver macrophages: a mechanism for elimination of enzymes from plasma. Evidence for competition by creatine kinase MM, adenylate kinase, malate, and alcohol dehydrogenase.

1987 • 55 citations

Cytoprotective effect of prostaglandins on isolated rat liver cells

1985 • 54 citations

Platelet secretory products inhibit lipoprotein metabolism in macrophages

1985 • 53 citations

Biosynthesis of platelet-activating factor by cultured rat Kupffer cells stimulated with calcium ionophore A23187

1989 • 53 citations

Hepatic binding of DNA is mediated by a receptor on nonparenchymal cells.

1988 • 53 citations

Identification of Receptors for Platelet-Activating Factor in Rat Kupffer Cells

1989 • 52 citations

Fc receptors of liver sinusoidal endothelium in normal rats and humans

1987 • 52 citations

Platelet C1q receptor interactions with collagen- and C1q-coated surfaces.

1990 • 50 citations

Human liver Kupffer cells express CR1, CR3, and CR4 complement receptor antigens. An immunohistochemical study.

1989 • 50 citations

Hepatic mechanisms for clearance and detoxification of bacterial endotoxins

1990 • 48 citations

Role of bacterial association with Kupffer cells in occurrence of endogenous systemic bacteremia

1991 • 48 citations

Natural cytotoxicity of isolated rat liver cells.

1982 • 47 citations

A membrane-associated form of C-reactive protein is the galactose-specific particle receptor on rat liver macrophages.

1990 • 46 citations

Fibronectin and Kupffer cell function in fulminant hepatic failure

1985 • 46 citations

Transferrin: Receptor-Mediated Endocytosis and Iron Delivery

1985 • 44 citations

The Role of the Immune Response in the Pathogenesis of Primary Biliary Cirrhosis

1981 • 42 citations

A new Kupffer cell receptor mediating plasma clearance of carcinoembryonic antigen by the rat

1982 • 39 citations

Scavenger receptor-mediated recognition of maleylated albumin and its relation to subsequent endocytic degradation

1989 • 38 citations

Kupffer Cells May Autoregulate Interleukin 1 Production by Producing Interleukin 1 Inhibitor and Prostaglandin E₂

1988 • 38 citations

Activation of murine kupffer cell tumoricidal activity by liposomes containing lipophilic muramyl dipeptide

1988 • 37 citations

Differential sensitivity of tumor targets to liver macrophage-mediated cytotoxicity.

1987 • 37 citations

Effect of endotoxin on fibronectin and kupffer cell activity

1985 • 37 citations

Correction of Serum Opsonic Defects After Burn and Sepsis by Opsonic Fibronectin Administration

1983 • 36 citations

Functional and Biochemical Properties of Rat Kupffer Cells and Peritoneal Macrophages

1988 • 34 citations

The location of binding sites on C1q for DNA.

1990 • 34 citations

The Kupffer cell in experimental extrahepatic cholestasis in the rat—a light microscopy, immunohistochemical and electron microscopy study

1986 • 33 citations

Modified lysosomal compartment as carrier of slowly and non-degradable tracers in macrophages.

1990 • 32 citations

Uptake and degradation in vivo and in vitro of laminin and nidogen by rat liver cells

1989 • 32 citations

Endocytosis of lysosomal enzymes by non-parenchymal rat liver cells. Comparative study of lysosomal-enzyme uptake by hepatocytes and non-parenchymal liver cells

1979 • 32 citations

Several dehydrogenases and kinases compete for endocytosis from plasma by rat tissues

1985 • 31 citations

CELLULAR BASIS OF TRANSPLANTATION TOLERANCE INDUCED BY LIVER GRAFTING IN THE RAT

1988 • 31 citations

Uptake and degradation of human low-density lipoprotein by human liver parenchymal and Kupffer cells in culture

1991 • 30 citations

Genetic control of the immune response to myoglobin. III. Determinant-specific, two Ir gene phenotype is regulated by the genotype of reconstituting Kupffer cells.

1980 • 30 citations

Bacterial clearance in the intact and regenerating liver

1985 • 27 citations

Binding and receptor-mediated endocytosis of pregnancy zone protein-proteinase complex in rat macrophages

1987 • 27 citations

Visualization of the interaction of native and modified lipoproteins with parenchymal, endothelial and Kupffer cells from human liver

1991 • 26 citations

Partial Hepatectomy Augments the Liver's Antitumor Response

1989 • 26 citations

Regulation of Platelet-activating Factor Receptors in Rat Kupffer Cells

1989 • 26 citations

Interaction in vivo and in vitro of apolipoprotein E-free high-density lipoprotein with parenchymal, endothelial and Kupffer cells from rat liver

1988 • 26 citations

Uptake of lactoferrin by the liver. III. Critical role of the protein moiety.

1984 • 25 citations

Membrane lipids of hepatocytes, Kupffer cells and endothelial cells

1983 • 25 citations

Effects of aspirin on gastric mucosal prostaglandin E2 and F2α content and on gastric mucosal injury in humans receiving fish oil or olive oil

1990 • 24 citations

Immunohistochemical studies on hemoglobin-haptoglobin and hemoglobin catabolism sites.

1987 • 24 citations

Electron microscopic observations on the accumulation of large granular lymphocytes (pit cells) and kupffer cells in the liver of rats treated with continuous infusion of interleukin-2

1990 • 24 citations

Role of Kupffer Cells, Complement, and Specific Antibody in Bactericidal Activities of Perfused Livers

1980 • 24 citations

Red cell aging results in a change of cell surface carbohydrate epitopes allowing for recognition by galactose-specific receptors of rat liver macrophages.

1988 • 23 citations

Uptake of lactoferrin by the liver. II. Endocytosis by sinusoidal cells.

1984 • 23 citations

Uptake and modification of125I-lipopolysaccharide by isolated rat Kupffer cells

1988 • 23 citations

Endogeneous interferon α/β produced by murine Kupffer cells augments liver-associated natural killing activity

1989 • 22 citations

Polymeric IgA and Galactose-Specific Pathways in Rat Hepatocytes: Evidence for Intracellular Ligand Sorting

1985 • 22 citations

Binding of Metastatic Colon Carcinoma Cells to Liver Macrophages

1989 • 22 citations

Induction of tumoricidal activity in isolated rat liver macrophages by liposomes containing recombinant rat gamma-interferon supplemented with lipopolysaccharide or muramyldipeptide.

1987 • 22 citations

The importance of the Fc receptors for IgA in the recognition of IgA by mouse liver cells: its comparison with carbohydrate and secretory component receptors.

1986 • 21 citations

In Vitro Cytostatic Properties of Unactivated Rat Kupffer Cells

1984 • 21 citations

High-Affinity Binding of Fibronectin to Cultured Kupffer Cells

1990 • 19 citations

Carcinoembryonic antigen binding to Kupffer cells is via a peptide located at the junction of the N-terminal and first loop domains

1990 • 19 citations

Preclustered receptor arrangement is a prerequisite for galactose-specific clearance of large participate ligands in rat liver

1989 • 17 citations

C1q receptor on murine cells.

1990 • 17 citations

Fibronectin-Enhanced Attachment of Gelatin-Coated Erythrocytes to Isolated Hepatic Kupffer Cells

1984 • 17 citations

DNA-binding domains of fibronectin probed using Western blots

1982 • 17 citations

Lysosomal and endosomal heterogeneity in the liver: A comparison of the intracellular pathways of endocytosis in rat liver cells

1991 • 17 citations

Defective Fc receptor-mediated clearance in patients with primary biliary cirrhosis

1991 • 16 citations

Decreased Fc Receptor Expression on Macrophages Following Simple Hemorrhage as Observed by Scanning Immunoelectron Microscopy

1990 • 15 citations

Characteristics of the Strongly Ia‐Positive Cells in Rat Liver

1984 • 15 citations

Reticuloendothelial system Fc receptor-mediated clearance of IgG-tagged erythrocytes from the circulation of patients with idiopathic ulcerative colitis and chronic liver disease

1986 • 15 citations

Receptor-Mediated Endocytosis of Carcinoembryonic Antigen by Rat Alveolar Macrophages In Vitro

1989 • 15 citations

Defect of sinusoidal Fc receptors and immune complex uptake in CCl4-induced liver cirrhosis in rats

1990 • 15 citations

A Membrane-Bound Form of the Acute-Phase Protein C-Reactive Protein Is the Galactose-Specific Particle Receptor on Rat Liver Macrophages

1991 • 15 citations

Human recombinant macrophage colony stimulating factor activates murine Kupffer cells to a cytotoxic state.

1990 • 13 citations

Uptake of processing of glycoproteins by isolated rat hepatic endothelial and Kupffer cells

1990 • 13 citations

Receptor-mediated endocytosis by human Kupffer cells

1988 • 11 citations

Immune Complex‐induced Disseminated Intravascular Coagulation (DIC) An Experimental Study

1990 • 10 citations

Endocytosis of bovine lactoperoxidase by two carbohydrate-specific receptors in rat liver

1985 • 10 citations

Beneficial effect of fibronectin administration on chronic nephritis in rats

1990 • 10 citations

Hepatocytes enhance Kupffer cell-mediated tumor cell cytostasis in vitro.

1989 • 9 citations

Defective hepatic handling of IgA immune aggregates by mice with experimental IgA nephropathy.

1989 • 8 citations

Effect of repetitive low-dose endotoxin on liver parenchymal and kupffer cell fibronectin release

1989 • 8 citations

Serum ?-N-acetyl hexosaminidase and bile acid levels in patients with benign and malignant biliary obstruction

1988 • 8 citations

Hepatic clearance and metabolism in the rat of a human breast cancer associated glycoprotein (GCDFP-15)

1988 • 8 citations

Inhibition of specific Kupffer-cell clearance of carcinoembryonic antigen from the serum of rats with bile-duct obstruction

1982 • 7 citations

Transferrin receptor on rat Kupffer cells in primary culture

1986 • 5 citations

Kupffer cell complement receptor clearance function after surgical injury and phagocytosis of immune complexes: effect of changes in plasma fibronectin.

1988 • 5 citations

Book review

1991 • 3 citations

Pregnancy-related changes of galactose recognition system on sinusoidal rat liver cells.

1989 • 2 citations