Transferrin: Receptor-Mediated Endocytosis and Iron Delivery

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Coated pits, coated vesicles, and receptor-mediated endocytosis

1979 • 2,073 citations

Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor

1983 • 1,757 citations

Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes.

1983 • 1,586 citations

Endocytosis and the recycling of plasma membrane.

1983 • 1,447 citations

Iron Transport and Storage Proteins

1980 • 1,183 citations

pH and the recycling of transferrin during receptor-mediated endocytosis.

1983 • 1,165 citations

The Role of Sialic Acid in Determining the Survival of Glycoproteins in the Circulation

1971 • 1,061 citations

Intracellular site of asialoglycoprotein receptor-ligand uncoupling: Double-label immunoelectron microscopy during receptor-mediated endocytosis

1983 • 816 citations

Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells.

1980 • 798 citations

Recycling receptors: The round-trip itinerary of migrant membrane proteins

1983 • 780 citations

Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin.

1981 • 699 citations

Human cell surface glycoprotein related to cell proliferation is the receptor for transferrin.

1981 • 685 citations

Rapid acidification of endocytic vesicles containing α2-macroglobulin

1982 • 672 citations

Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 cells.

1983 • 636 citations

Virus Entry into Animal Cells

1989 • 625 citations

Binding of apotransferrin to K562 cells: explanation of the transferrin cycle.

1983 • 603 citations

Receptor-mediated endocytosis of transferrin in K562 cells.

1983 • 576 citations

Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line. Effect of lysosomotropic agents.

1983 • 558 citations

Journey to the Center of the Cell: Role of the Receptosome

1981 • 500 citations

Receptor-mediated endocytosis of transferrin in developmentally totipotent mouse teratocarcinoma stem cells.

1981 • 497 citations

Receptor-mediated endocytosis of transferrin and the uptake of fe in K562 cells: identification of a nonlysosomal acidic compartment.

1982 • 486 citations

The galactose-specific recognition system of mammalian liver: The route of ligand internalization in rat hepatocytes

1980 • 484 citations

Transferrin receptor induction in mitogen-stimulated human T lymphocytes is required for DNA synthesis and cell division and is regulated by interleukin 2.

1983 • 448 citations

THE PLASMA-TO-CELL CYCLE OF TRANSFERRIN*

1963 • 432 citations

The receptosome: An intermediate organelle of receptor-mediated endocytosis in cultured fibroblasts

1980 • 398 citations

Receptor-Mediated Endocytosis of Hormones in Cultured Cells

1981 • 388 citations

Studies on glycoconjugates. LXIV. Complete structure of two carbohydrate units of human serotransferrin

1975 • 361 citations

Primary structure of human transferrin receptor deduced from the mRNA sequence

1984 • 351 citations

The human transferrin receptor gene: genomic organization, and the complete primary structure of the receptor deduced from a cDNA sequence

1984 • 337 citations

Monoclonal antibody to transferrin receptor blocks transferrin binding and inhibits human tumor cell growth in vitro.

1982 • 335 citations

Partial replacement of serum by selenite, transferrin, albumin and lecithin in haemopoitec cell cultures

1976 • 319 citations

Biosynthesis of the human transferrin receptor in cultured cells.

1981 • 316 citations

Human melanoma-associated antigen p97 is structurally and functionally related to transferrin

1982 • 288 citations

The synergistic binding of anions and Fe3+ by transferrin. Implications for the interlocking sites hypothesis.

1975 • 285 citations

Proteins of iron metabolism

1977 • 282 citations

Anti-transferrin receptor monoclonal antibody and toxin–antibody conjugates affect growth of human tumour cells

1981 • 275 citations

Structural features of the cell surface receptor for transferrin that is recognized by the monoclonal antibody OKT9.

1982 • 275 citations

The primary structure of human serum transferrin. The structures of seven cyanogen bromide fragments and the assembly of the complete structure.

1983 • 272 citations

Changes in cell surface antigen expression during hemopoietic differentiation

1982 • 260 citations

Adenovirus-induced release of epidermal growth factor and pseudomonas toxin into the cytosol of KB cells during receptor-mediated endocytosis

1983 • 256 citations

Covalent binding of fatty acid to the transferrin receptor in cultured human cells.

1981 • 246 citations

Evidence for the sorting of endocytic vesicle contents during the receptor-mediated transport of IgG across the newborn rat intestine.

1981 • 244 citations

Structure of Glycoproteins and Their Oligosaccharide Units

1980 • 243 citations

The kinetics of transferrin endocytosis and iron uptake from transferrin in rabbit reticulocytes.

1983 • 222 citations

Isolation and characterization of the transferrin receptor from human placenta.

1979 • 215 citations

Growth and maintenance of HeLa cells in serum-free medium supplemented with hormones.

1978 • 208 citations

Transferrin receptor and its recycling in HeLa cells.

1982 • 206 citations

Luminal membrane retrieved after exocytosis reaches most Golgi cisternae in secretory cells

1977 • 204 citations

The transferrin receptor

1982 • 202 citations

Morphologic characterization of the pathway of transferrin endocytosis and recycling in human KB cells.

1984 • 202 citations

Biological aspects of metals and metal-related diseases

1983 • 198 citations

Effect of tunicamycin on the secretion of serum proteins by primary cultures of rat and chick hepatocytes. Studies on transferrin, very low density lipoprotein, and serum albumin

1978 • 195 citations

Molecular cloning and nucleotide sequence of a transforming gene detected by transfection of chicken B-cell lymphoma DNA

1983 • 194 citations

Transmembrane assembly of membrane and secretory glycoproteins

1981 • 188 citations

Identification of transferrin receptors on the surface of human cultured cells.

1979 • 185 citations

Fate of receptor and ligand during endocytosis of asialoglycoproteins by isolated hepatocytes.

1982 • 178 citations

Bicarbonate and the Binding of Iron to Transferrin

1967 • 177 citations

Kinetics of transit of transferrin and epidermal growth factor through clathrin-coated membranes

1984 • 174 citations

Transferrin receptor in human placental brush border membranes. Studies on the binding of transferrin to placental membrane vesicles and the identification of a placental brush border glycoprotein with high affinity for transferrin.

1979 • 174 citations

Internalization and subcellular localization of transferrin and transferrin receptors in HeLa cells.

1983 • 172 citations

Transferrin receptors and iron uptake during erythroid cell development

1982 • 164 citations

The asialoglycoprotein receptor internalizes and recycles independently of the transferrin and insulin receptors

1983 • 161 citations

Transferrin as a fetal growth factor: acquisition of responsiveness related to embryonic induction.

1983 • 158 citations

Polynuclear complexes of iron and their biological implications

2008 • 153 citations

Autoradiographic Localization of 125I-Labelled Transferrin in Rabbit Reticulocytes

1969 • 153 citations

Transit of epidermal growth factor through coated pits of the Golgi system.

1982 • 144 citations

Iron uptake and utilization by mammalian cells. I: Cellular uptake of transferrin and iron

1983 • 136 citations

Transferrin Uptake by Cultured Rat Embryo Fibroblasts

2005 • 134 citations

Morphologic study of the internalization of a lysosomal enzyme by the mannose 6-phosphate receptor in cultured Chinese hamster ovary cells.

1981 • 131 citations

The Role of Endocytosis in Transferrin Uptake by Reticulocytes and Bone Marrow Cells

1977 • 128 citations

Micropinocytosis of transferrin by developing red cells: an electron- microscopic study utilizing ferritin-conjugated transferrin and ferritin-conjugated antibodies to transferrin

1976 • 121 citations

The interaction of transferin with isolated hepatocytes

1980 • 119 citations

An abnormal membrane glycoprotein associated with malignancy in a wide range of different tumours

1978 • 117 citations

The mechanism of iron exchange between synthetic iron chelators and rabbit reticulocytes

1974 • 117 citations

Transferrin receptors and the uptake and release of iron by isolated hepatocytes

1981 • 112 citations

Pathways followed by membrane recovered from the surface of plasma cells and myeloma cells

1980 • 109 citations

Divergence of epidermal growth factor and transferrin during receptor-mediated endocytosis

1983 • 104 citations

Receptor for transferrin may be a "target" structure for natural killer cells.

1983 • 103 citations

Modulation of T leukaemic cell phenotype with phorbol ester

1982 • 103 citations

Transferrin receptors during rabbit reticulocyte maturation

1979 • 101 citations

Internalization of insulin into rat liver Golgi elements. Evidence for vesicle heterogeneity and the path of intracellular processing.

1982 • 98 citations

Inhibition of reticulocyte iron uptake by NH4Cl and CH3NH2

1981 • 97 citations

The entry of viruses into animal cells

1980 • 96 citations

A monoclonal antibody that detects expression of transferrin receptor in human erythroid precursor cells

1982 • 92 citations

The reduction and release of iron from Fe3+ .transferrin.CO3(2-).

1979 • 91 citations

The morphologic pathway of binding and internalization of epidermal growth factor in cultured cells

1983 • 90 citations

Distribution of receptors for transferrin and low density lipoprotein on the surface of giant HeLa cells.

1983 • 87 citations

Receptor-mediated endocytosis of transferrin by developing erythroid cells from the fetal rat liver.

1983 • 86 citations

Co-migration and internalization of transferrin and its receptor on K562 cells.

1983 • 82 citations

Receptor-rich intracellular membrane vesicles transporting asialotransferrin and insulin in liver

1982 • 81 citations

Evidence for the bilobal nature of diferric rabbit plasma transferrin

1979 • 79 citations

Assignment of the gene for human melanoma-associated antigen p97 to chromosome 3

1983 • 79 citations

The formation of iron-binding fragments of hen ovotransferrin by limited proteolysis

1974 • 78 citations

Iron removal from transferrin An experimental study

1977 • 74 citations

Isolation and characterization of a highly enriched preparation of receptosomes (endosomes) from a human cell line.

1983 • 73 citations

Enhancement of toxicity of antitransferrin receptor antibody-Pseudomonas exotoxin conjugates by adenovirus.

1983 • 72 citations

Expression of human transferrin receptor is controlled by a gene on chromosome 3: Assignment using species specificity of a monoclonal antibody

1982 • 71 citations

Radioimmunochemical measurement of the transferrin receptor in human trophoblast and reticulocyte membranes with a specific anti-receptor antibody.

1981 • 70 citations

Differences between the binding sites for iron binding and release in human and rat transferrin

1978 • 70 citations

Transferrin Receptor in Human Placental Brush Border Membranes

1979 • 67 citations

Structure and function of transferrin.

1975 • 66 citations

Transferrin protein and iron uptake by cultured hepatocytes

1982 • 64 citations

Size and shape determination of apotransferrin and transferrin monomers

1971 • 63 citations

Iron-binding fragments from the carboxyl-terminal region of hen ovotransferrin

1975 • 59 citations

Transferrin Receptors in Developing Murine Erythroid Cells

1977 • 59 citations

Factors affecting the adenosine triphosphate induced release of iron from transferrin

1978 • 56 citations

Iron exchange between transferrin molecules mediated by phosphate compounds and other cell metabolites

1977 • 56 citations

Transferrin and Iron Uptake by Rabbit Bone Marrow Cells in Vitro

1974 • 55 citations

Function of three cytochromes in photosynthesis of whole cells of Rhodospirillum rubrum as studied by flash spectroscopy. Evidence for two types of reaction center

1976 • 54 citations

Dual nature of the hepatic lectin pathway for human asialotransferrin type 3 in the rat.

1982 • 53 citations

Studies of the Metabolism of Asialotransferrins: Potentiation of the Catabolism of Human Asialotransferrin in the Rabbit

1974 • 53 citations

The effect of pH on the kinetics of iron release from human transferrin

1982 • 52 citations

Selection and properties of a mouse L-cell transformant expressing human transferrin receptor

1983 • 52 citations

Dual pathways for epidermal growth factor processing after receptor‐mediated endocytosis

1982 • 52 citations

Similarities between the transferrin receptor proteins on human reticulocytes and human placentae.

1981 • 51 citations

Preparation and characterization of an NH2-terminal fragment of human serum transferrin containing a single iron-binding site.

1980 • 50 citations

Dual pathways for the uptake of rat asialotransferrin by rat hepatocytes.

1983 • 48 citations

Distribution of the transferrin receptor in normal human fibroblasts and fibrosarcoma cells

1983 • 48 citations

Transferrin and iron uptake by human cells in culture

1974 • 47 citations

Galactose‐Specific Endocytosis in Rat Liver

1983 • 40 citations

Cleavage of diferric bovine transferrin into two monoferric fragments

1976 • 38 citations

The transferrin cycle and iron uptake in rabbit reticulocytes. Pulse studies using 59Fe, 125I-labeled transferrin.

1983 • 37 citations

Transport by proteins

1979 • 37 citations

Accumulation of epidermal growth factor within cells does not depend on receptor recycling

1980 • 36 citations

Identification of 125I-labeled rat reticulocyte membrane proteins with affinity for transferrin

1978 • 34 citations

Uptake of transferrin by rat peritoneal macrophages

1982 • 30 citations

Placental transferrin receptor. Evaluation of the presence of endogenous ligand on specific binding.

1983 • 30 citations

Transferrin protein and iron uptake by isolated rat erythroblasts

1982 • 29 citations

Expression of transferrin receptors during erythroid maturation

1983 • 29 citations

Transferrin: Internal Homology in the Amino Acid Sequence

1975 • 29 citations

Hepatic uptake and degradation of trace doses of asialofetuin and asialoorosomucoid in the intact rat

1979 • 28 citations

Transferrin Uptake by Rabbit Alveolar Macrophages in Vitro

1977 • 25 citations

Identification of 125I-labeled rat reticulocyte membrane proteins with affinity for transferrin

1978 • 25 citations

Structures and Bonding

1970 • 20 citations

Transferrin Endocytosis in Reticulocytes: An Electron Microscope Study using Colloidal Gold

1982 • 19 citations

Effect of changes in the ionic environment of reticulocytes on the uptake of transferrin‐bound iron

1980 • 17 citations

Conformations of denatured and renatured ovotransferrin

1979 • 14 citations

The Biochemistry of Glycoprotein and Proteoglycans

1981 • 12 citations

THERMODYNAMIC AND ACCESSIBILITY FACTORS IN THE SPECIFIC BINDING OF IRON TO HUMAN TRANSFERRIN

1978 • 9 citations