Visualization of the interaction of native and modified lipoproteins with parenchymal, endothelial and Kupffer cells from human liver

Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).

1984 • 3,268 citations

The plasma lecithin:cholesterol acyltransferase reaction

1968 • 2,415 citations

Separation of plasma lipoproteins by density-gradient ultracentrifugation

1975 • 1,114 citations

Role of lysine residues of plasma lipoproteins in high affinity binding to cell surface receptors on human fibroblasts.

1978 • 621 citations

Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins.

1989 • 600 citations

Increased binding of low density lipoprotein to liver membranes from rats treated with 17 alpha-ethinyl estradiol.

1979 • 571 citations

Dissociation of tissue uptake of cholesterol ester from that of apoprotein A-I of rat plasma high density lipoprotein: selective delivery of cholesterol ester to liver, adrenal, and gonad.

1983 • 490 citations

Liver Transplantation to Provide Low-Density-Lipoprotein Receptors and Lower Plasma Cholesterol in a Child with Homozygous Familial Hypercholesterolemia

1984 • 442 citations

Acetoacetylated lipoproteins used to distinguish fibroblasts from macrophages in vitro by fluorescence microscopy.

1981 • 396 citations

Subfractionation of human high density lipoproteins by heparin-Sepharose affinity chromatography.

1980 • 349 citations

Monoclonal antibody to keratin filaments, specific for glandular epithelia and their tumors. Use in surgical pathology.

1983 • 268 citations

Monoclonal antibodies to desmin, the muscle-specific intermediate filament protein.

1983 • 239 citations

Uptake of chemically modified low density lipoproteins in vivo is mediated by specific endothelial cells.

1985 • 219 citations

Discrimination of Human Macrophages and Dendritic Cells by Means of Monoclonal Antibodies

1986 • 199 citations

Plasminogen Activator Inhibitor 1: Biosynthesis and mRNA Level Are Increased by Insulin in Cultured Human Hepatocytes

1989 • 190 citations

Interaction of high density lipoprotein with its receptor on cultured fibroblasts and macrophages. Evidence for reversible binding at the cell surface without internalization.

1987 • 141 citations

Detection of factor VIII/coagulant antigen in human liver tissue

1983 • 124 citations

Binding of high density lipoprotein to cultured fibroblasts after chemical alteration of apoprotein amino acid residues.

1986 • 122 citations

Autoradiographic localization of the sites of uptake, cellular transport, and catabolism of low density lipoproteins in the liver of normal and estrogen-treated rats

1981 • 118 citations

Rat high density lipoprotein subfraction (HDL3) uptake and catabolism by isolated rat liver parenchymal cells.

1976 • 114 citations

Morphological evidence that high density lipoproteins are not internalized by steroid-producing cells during in situ organ perfusion.

1984 • 111 citations

Endocytosis of formaldehyde-treated serum albumin via scavenger pathway in liver endothelial cells

1984 • 111 citations

Tissue sites of degradation of native and reductively methylated [14C]sucrose-labeled low density lipoprotein in rats. Contribution of receptor-dependent and receptor-independent pathways.

1982 • 110 citations

Characterization of a human hepatic receptor for high density lipoproteins.

1985 • 104 citations

Apolipoproteins of high, low, and very low density lipoproteins in human bile

1983 • 102 citations

Uptake of cholesterol-rich remnant lipoproteins by human monocyte-derived macrophages is mediated by low density lipoprotein receptors.

1988 • 101 citations

High-affinity uptake and degradation of ApoE-free high-density lipoprotein and low-density lipoprotein in cultured porcine hepatocytes

1982 • 101 citations

Monoclonal antibodies as probes for defining cellular subsets in the bone marrow, thymus, bursa of Fabricius, and spleen of the chicken

1988 • 96 citations

Hormonal regulation of low‐density lipoprotein (LDL) receptor activity in human hepatoma Hep G2 cells

1988 • 95 citations

Receptor-mediated catabolism of homologous low density lipoproteins in cultured pig hepatocytes.

1981 • 94 citations

Uptake of rat plasma HDL subfractions labeled with [3H]cholesteryl linoleyl ether or with 125I by cultured rat hepatocytes and adrenal cells

1984 • 93 citations

Ketoconazole blocks bile acid synthesis in hepatocyte monolayer cultures and in vivo in rat by inhibiting cholesterol 7 alpha-hydroxylase.

1986 • 86 citations

Cultured human hepatocytes. Evidence for metabolism of low density lipoproteins by a pathway independent of the classical low density lipoprotein receptor.

1986 • 84 citations

The uptake of the apoprotein and cholesteryl ester of high-density lipoproteins by the perfused rat liver

1987 • 67 citations

Experimental hypothyroidism modulates the expression of the low density lipoprotein receptor by the liver

1986 • 67 citations

Characterization of hepatic low density lipoprotein binding and cholesterol metabolism in normal and homozygous familial hypercholesterolemic subjects.

1984 • 65 citations

Acetaldehyde modification of low density lipoprotein accelerates its catabolism in man

1987 • 62 citations

Uptake and degradation of 125I-labelled high density lipoproteins in rat liver cells in vivo and in vitro

1979 • 62 citations

The fate of cholesteryl linoleyl ether and cholesteryl linoleate in the intact rat after injection of biologically labeled human low density lipoprotein

1981 • 60 citations

Saturable high affinity binding, uptake and degradation of rat plasma lipoproteins by isolated parenchymal and non-parenchymal cells from rat liver

1981 • 58 citations

Difference in saturable binding of low density lipoprotein to liver membranes from normocholesterolemic subjects and patients with heterozygous familial hypercholesterolemia.

1982 • 57 citations

Isolation of a porcine liver plasma membrane fraction that binds low density lipoproteins

1978 • 56 citations

Quantitative role of parenchymal and non-parenchymal liver cells in the uptake of [14C]sucrose-labelled low-density lipoprotein in vivo

1984 • 56 citations

Characterization of high-density lipoprotein binding sites in rat liver and testis membranes

1984 • 52 citations

Saturable high affinity binding of low density and high density lipoprotein by parenchymal and non-parenchymal cells from rat liver

1980 • 51 citations

Modification of human high density lipoprotein (HDL3) with tetranitromethane and the effect on its binding to isolated rat liver plasma membranes.

1985 • 51 citations

The binding of high density lipoproteins to isolated rat hepatocytes

1981 • 51 citations

Immunohistochemical localization of low density lipoprotein receptors in adrenal gland, liver, and intestine.

1989 • 50 citations

Detection and quantitation of low density lipoprotein (LDL) receptors in human liver by ligand blotting, immunoblotting, and radioimmunoassay. LDL receptor protein content is correlated with plasma LDL cholesterol concentration.

1986 • 50 citations

Up-regulation of high density lipoprotein receptor activity by gamma-interferon associated with inhibition of cell proliferation.

1988 • 46 citations

Binding of acetylated low density lipoprotein and maleylated bovine serum albumin to the rat liver: one or two receptors?

1987 • 45 citations

Membrane binding sites for plasma lipoproteins on endosomes from rat liver.

1989 • 42 citations

Regulation of low density lipoprotein receptor activity in primary cultures of human hepatocytes by serum lipoproteins

1986 • 41 citations

Hepatic processing of the cholesteryl ester from low density lipoprotein in the rat.

1986 • 35 citations

Binding properties of high-density lipoprotein subfractions and low-density lipoproteins to rabbit hepatocytes

1982 • 35 citations

Cellular localization of the receptor‐dependent and receptor‐independent uptake of human LDL in the liver of normal and 17α‐ethinyl estradiol‐treated rats

1983 • 34 citations

Interactions of triiodothyronine, insulin and dexamethasone on the binding of human LDL to rat hepatocytes in monolayer culture

1988 • 33 citations

A saturable, high-affinity binding site for human low density lipoprotein on freshly isolated rat hepatocytes

1982 • 30 citations

Characterization in vitro of interaction of human apolipoprotein E-free high density lipoprotein with human hepatocytes.

1990 • 30 citations

Comparison of taurocholate accumulation in cultured hepatocytes of pig, rat and man

1989 • 28 citations

The effect of Ca²⁺ and trifluoperazine on the processing of human acetylated low density lipoprotein by non‐parenchymal liver cells

1981 • 28 citations

In vivo and in vitro catabolism of native and biologically modified LDL

1984 • 26 citations

Interaction in vivo and in vitro of apolipoprotein E-free high-density lipoprotein with parenchymal, endothelial and Kupffer cells from rat liver

1988 • 26 citations

Effect of apolipoprotein E-free high density lipoproteins on cholesterol metabolism in cultured pig hepatocytes.

1987 • 25 citations

Visualization of the interaction of native and modified low density lipoproteins with isolated rat liver cells.

1985 • 25 citations

Metabolism of low-density lipoproteins by cultured hepatocytes from normal and homozygous familial hypercholesterolemic subjects

1986 • 24 citations

Demonstration of a high density lipoprotein (HDL)‐binding protein in Hep G2 cells using colloidal gold‐HDL conjugates

1988 • 21 citations

Human hepatic low-density lipoprotein receptors: associations of receptor activities in vitro with plasma lipid and apolipoprotein concentrations in vivo

1989 • 17 citations

High‐affinity association and degradation of ¹²⁵I‐labelled low density lipoproteins by human hepatocytes in primary culture

1985 • 17 citations

Light- and immunoelectron microscopic visualization of in vivo endocytosis of low density lipoprotein by hepatocytes and Kupffer cells in rat liver.

1990 • 16 citations

Effects of truncal vagotomy on tissue gastrin content and G cell density in rats

1981 • 9 citations

Receptor-independent low-density lipoprotein catabolism

1984 • 8 citations

Hypothyroidism reduces HDL binding to rat liver cells

1989 • 8 citations

Binding and uptake of native and modified low-density lipoproteins by human hepatocytes in primary culture

1989 • 5 citations

Metabolism of lipoproteins by human fetal hepatocytes

1987 • 3 citations