The liver and IgA: Immunological, cell biological and clinical implications

Carbohydrate-Specific Receptors of the Liver

1982 • 1,895 citations

CHARACTERISTICS OF AN IMMUNE SYSTEM COMMON TO CERTAIN EXTERNAL SECRETIONS

1965 • 1,014 citations

Immunoglobulin A (IgA): Molecular and Cellular Interactions Involved in IgA Biosynthesis and Immune Response

1987 • 956 citations

Metabolism of Immunoglobulins

2015 • 733 citations

The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains

1984 • 507 citations

The galactose-specific recognition system of mammalian liver: The route of ligand internalization in rat hepatocytes

1980 • 484 citations

Direct evidence for an integrated function of J chain and secretory component in epithelial transport of immunoglobulins

1984 • 415 citations

Immunoglobulin A: Strategic Defense Initiative at the Mucosal Surface

1986 • 404 citations

Structure of the Carbohydrate Units of IgA1 Immunoglobulin

1974 • 382 citations

Intravascular and Mucosal Immunoglobulin A: Two Separate but Related Systems of Immune Defense?

1987 • 372 citations

Intracellular receptor sorting during endocytosis: Comparative immunoelectron microscopy of multiple receptors in rat liver

1984 • 359 citations

Gamma-Globulins: Quantitative Relationships in Human Serum and Nonvascular Fluids

1963 • 346 citations

Polymeric immunoglobulin receptor expressed in MDCK cells transcytoses IgA

1986 • 313 citations

Role of J Chain and Secretory Component in Receptor‐Mediated Glandular and Hepatic Transport of Immunoglobulins in Man

1985 • 312 citations

Novel Subunit in Secretory IgA

1970 • 294 citations

IgA subclasses in various secretions and in serum.

1982 • 285 citations

Studies on a mammalian hepatic binding protein specific for asialoglycoproteins. Evidence for receptor recycling in isolated rat hepatocytes.

1980 • 270 citations

Rapid active transport of immunoglobulin A from blood to bile.

1978 • 266 citations

Structure of the Carbohydrate Units of IgA1 Immunoglobulin

1974 • 263 citations

The human IgA system: A reassessment

1986 • 254 citations

An ATP-driven proton pump in clathrin-coated vesicles.

1983 • 253 citations

Receptor-mediated transcellular transport of immunoglobulin: synthesis of secretory component as multiple and larger transmembrane forms.

1980 • 244 citations

Selective transport of polymeric immunoglobulin A in bile. Quantitative relationships of monomeric and polymeric immunoglobulin A, immunoglobulin M, and other proteins in serum, bile, and saliva.

1982 • 237 citations

Biliary transport of IgA: role of secretory component.

1979 • 233 citations

Rapid disappearance from serum of intravenously injected rat myeloma IgA and its secretion into bile

1978 • 221 citations

A transmembrane precursor of secretory component. The receptor for transcellular transport of polymeric immunoglobulins.

1982 • 220 citations

Evidence for a Vesicular Transport Mechanism in Hepatocytes for Biliary Secretion of Immunoglobulin A

1980 • 219 citations

Acidification of endocytic vesicles by an ATP-dependent proton pump.

1983 • 217 citations

Deletion of the cytoplasmic domain of the polymeric immunoglobulin receptor prevents basolateral localization and endocytosis

1986 • 202 citations

ANTIBODIES TO INTESTINAL MICROBES IN SERUM OF PATIENTS WITH CIRRHOSIS OF THE LIVER

1972 • 191 citations

Studies on Translocation of Immunoglobulins Across Intestinal Epithelium

1976 • 189 citations

IGA in human bile and liver.

1981 • 189 citations

Circulating immune complexes and immunoglobulin A rheumatoid factor in patients with mesangial immunoglobulin A nephropathies.

1986 • 188 citations

IgA interaction with the asialoglycoprotein receptor.

1982 • 184 citations

Proteolytic degradation of exocrine and serum immunoglobulins

1970 • 178 citations

Fate of receptor and ligand during endocytosis of asialoglycoproteins by isolated hepatocytes.

1982 • 178 citations

Changes in size, subclass, and metabolic properties of serum immunoglobulin A in liver diseases and in other diseases with high serum immunoglobulin A.

1983 • 178 citations

Intracellular dissociation of receptor-bound asialoglycoproteins in cultured hepatocytes. A pH-mediated nonlysosomal event.

1983 • 176 citations

Hormonal induction of the secretory immune system in the mammary gland.

1978 • 175 citations

Bile Secretory Apparatus: Evidence for a Vesicular Transport Mechanism for Proteins in the Rat, Using Horseradish Peroxidase and [125I]Insulin

1980 • 172 citations

Rat bile as a convenient source of secretory IgA and free secretory component

1977 • 170 citations

Ultrastructural localization of carcinoembryonic antigen in normal intestine and colon cancer. Abnormal distribution of cea on the surfaces of colon cancer cells

1982 • 159 citations

HYPERGLOBULINÆMIA IN LIVER DISEASE

1973 • 159 citations

Tumor necrosis factor-alpha up-regulates expression of secretory component, the epithelial receptor for polymeric Ig.

1988 • 159 citations

Translocation of Dimeric IgA through Neoplastic Colon Cells in Vitro

1979 • 158 citations

Identification of secretory component as an IgA receptor on rat hepatocytes.

1979 • 155 citations

IGA in human bile and liver.

1981 • 155 citations

Evidence for a common mucosal immunologic system. II. Influence of the estrous cycle on B immunoblast migration into genital and intestinal tissues.

1980 • 153 citations

Receptor-mediated binding and uptake of immunoglobulin a by human liver

1988 • 152 citations

Secretory component as the receptor for polymeric IgA on rat hepatocytes.

1979 • 150 citations

Properties of immunoglobulin A in serum of individuals with liver diseases and in hepatic bile

1982 • 150 citations

Characterization of the asialoglycoprotein receptor on isolated rat hepatocytes.

1980 • 149 citations

In vitro Combination of Human and Bovine Free Secretory Component with IgA of Various Species

1970 • 141 citations

Secretion of immunoglobulins and plasma proteins from the jejunal mucosa. Transport rate and origin of polymeric immunoglobulin A.

1984 • 140 citations

Sex steroid hormone regulation of IgA and IgG in rat uterine secretions

1977 • 137 citations

Transcellular transport of polymeric IgA in the rat hepatocyte: biochemical and morphological characterization of the transport pathway.

1985 • 134 citations

IgA-associated renal diseases: Antibodies to environmental antigens in sera and deposition of immunoglobulins and antigens in glomeruli

1986 • 131 citations

Prevalence of IgA2 Deposits in IgA Nephropathies

1980 • 128 citations

High levels of secretory IgA and free secretory component in the serum of rats with bile duct obstruction.

1978 • 128 citations

Role of serum IgA. Hepatobiliary transport of circulating antigen.

1981 • 126 citations

The Human Gastrointestinal Secretory Immune System in Health and Disease

1985 • 124 citations

Immunological Diseases

1989 • 124 citations

Endocytosis and degradation mediated by the asialoglycoprotein receptor in isolated rat hepatocytes.

1982 • 123 citations

An electron microscope autoradiographic study of the carbohydrate recognition systems in rat liver. II. Intracellular fates of the 125I-ligands.

1979 • 123 citations

Receptor-mediated biliary transport of immunoglobulin A and asialoglycoprotein: sorting and missorting of ligands revealed by two radiolabeling methods.

1984 • 122 citations

The elimination of circulating complexes containing polymeric IgA by excretion in the bile.

1981 • 117 citations

Protein transmission through living membranes

1980 • 116 citations

Biosynthesis of the iga antibody receptor: A model for the transepithelial sorting of a membrane glycoprotein

1984 • 113 citations

Demonstration of Binding Sites for IgG Fc and the Third Complement Component (C3) on Isolated Hepatocytes

1976 • 110 citations

Immunohistochemical characterization of intracellular J-chain and binding site for secretory component (SC) in human immunoglobulin (Ig)-producing cells

1983 • 110 citations

Relevance of Biliary IgA Antibodies in Rat Intestinal Immunity

1978 • 109 citations

Serum immunoglobulins, complement component levels and autoantibodies in liver disease.

1973 • 106 citations

Local formation of gamma-globulin in the diseased liver, and its relation to hepatic necrosis.

1962 • 102 citations

The transport by hepatocytes of immunoglobulin A from blood to bile visualized by autoradiography and electron microscopy.

1979 • 100 citations

Intracellular and transcellular transport of secretory component and albumin in rat hepatocytes.

1983 • 100 citations

Role of secretory component, a secreted glycoprotein, in the specific uptake of IgA dimer by epithelial cells.

1979 • 99 citations

Die Primärstruktur der menschlichen freien Sekretkomponente und die Anordnung der Disulfidbrücken

1984 • 99 citations

Human secretory component—VI

1977 • 98 citations

Immunocytochemical localization of the receptor for asialoglycoprotein in rat liver cells.

1982 • 98 citations

Glomerular changes in patients with cirrhosis of the liver.

1977 • 98 citations

The immunochemical characterization of mesangial IgA deposits.

1983 • 96 citations

Secretory component-dependent hepatic transport of IgA antibody-antigen complexes.

1981 • 94 citations

Ultrastructural events in the translocation of polymeric IgA by rat hepatocytes.

1982 • 93 citations

The architecture of bile secretion

1980 • 93 citations

Analysis of circulating IgA and detection of immune complexes in primary IgA nephropathy.

1982 • 92 citations

Nature and Origin of the Proteins of Bile

1974 • 92 citations

Reticuloendothelial Function in Patients with Alcoholic Liver Cirrhosis

1981 • 91 citations

Steroid hormone regulation of free secretory component in the rat uterus.

1983 • 90 citations

The membrane receptor for polymeric immunoglobulin is structurally related to secretory component. Isolation and characterization of membrane secretory component from rabbit liver and mammary gland.

1981 • 90 citations

Studies on Translocation of Immunoglobulins Across Intestinal Epithelium

1977 • 89 citations

Hormonal influence on the secretory immune system of the eye: androgen regulation of secretory component levels in rat tears.

1984 • 89 citations

A Study of the Association of Human Secretory Component with IgA and IgM Proteins

1975 • 88 citations

Structures of the carbohydrate moieties of secretory component purified from human milk.

1982 • 86 citations

Endocytosis of asialoglycoprotein-enzyme conjugates by hepatocytes.

1980 • 83 citations

THE MINERS

1974 • 82 citations

Receptor-mediated endocytosis of polymeric IgA and galactosylated serum albumin in rat liver. Evidence for intracellular ligand sorting and identification of distinct endosomal compartments

1985 • 81 citations

Hepatobiliary transport of plasma IgA in the mouse: contribution to clearance of intravascular IgA

1985 • 81 citations

The large intracellular pool of asialoglycoprotein receptors functions during the endocytosis of asialoglycoproteins by isolated rat hepatocytes.

1983 • 80 citations

Hepatocyte Handling of Immunoglobulin a in the Rat: The Role of Microtubules

1983 • 79 citations

The pathway of the asialoglycoprotein-ligand during receptor-mediated endocytosis: a morphological study with colloidal gold/ligand in the human hepatoma cell line, Hep G2.

1983 • 78 citations

Variations in free secretory component levels in mucosal secretions of the rat.

1983 • 77 citations

Mesenteric lymph as a major source of serum IgA in guinea pigs and rats

1973 • 77 citations

Movement of endocytic shuttle vesicles from the sinusoidal to the bile canalicular face of hepatocytes does not depend on occupation of receptor sites

1980 • 76 citations

An anchor-minus form of the polymeric immunoglobulin receptor is secreted predominantly apically in Madin-Darby canine kidney cells.

1987 • 76 citations

Immunoglobulin A in the diagnosis of alcoholic liver disease

1988 • 75 citations

Ultrastructural Localization of J Chain in Human Intestinal Mucosa

1979 • 75 citations

Occurrence of Specific Antibodies of the IgA Class in the Bile of Rats

1979 • 75 citations

Detection of monomeric and polymeric IgA containing immune complexes in serum and kidney from patients with alcoholic liver disease.

1982 • 75 citations

The amino-terminal domain of rabbit secretory component is responsible for noncovalent binding to immunoglobulin A dimers.

1986 • 73 citations

Biogenesis of the polymeric IgA receptor in rat hepatocytes. I. Kinetic studies of its intracellular forms.

1985 • 72 citations

The Liver in the IgA Secretory Immune System. Dogs, But Not Rats and Rabbits, Are Suitable Models for Human Studies

1983 • 71 citations

Cleavage of membrane secretory component to soluble secretory component occurs on the cell surface of rat hepatocyte monolayers.

1987 • 71 citations

Synthesis of secretory component by colonic neoplasms.

1976 • 70 citations

Clinical, microbiological, and immunological studies in patients with immunoglobulin deficiencies and gastrointestinal disorders

1972 • 70 citations

Recycling of the hepatocyte asialoglycoprotein receptor does not require delivery of ligand to lysosomes.

1982 • 69 citations

In Vivo and in Vitro Binding of IgA to the Plasma Membrane of Hepatocytes

1978 • 68 citations

Biogenesis of the polymeric IgA receptor in rat hepatocytes. II. Localization of its intracellular forms by cell fractionation studies.

1985 • 68 citations

T and B cell function in alcoholic liver disease

1986 • 67 citations

Human IgA as a heterovalent ligand: switching from the asialoglycoprotein receptor to secretory component during transport across the rat hepatocyte.

1986 • 67 citations

The origin of IgA in chicken bile: its rapid active transport from blood

1981 • 66 citations

Comparison of human, bovine and rabbit secretory component-immunoglobulin interactions

1978 • 66 citations

Clearance kinetics and fate of mouse IgA immune complexes prepared with monomeric or dimeric IgA.

1983 • 66 citations

Hepatobiliary transport of IgA immune complexes: molecular and cellular aspects.

1982 • 65 citations

Alcoholic Hepatic Disease: Specificity of IgA Deposits in Liver

1979 • 64 citations

Secretory component: The polymeric immunoglobulin receptor

1985 • 63 citations

A Transmembrane Precursor of Secretory Component

1983 • 62 citations

Binding of secretory piece to polymeric IgA and IgM paraproteins in vitro.

1971 • 61 citations

In vivo experiments involving secretory component in the rat hepatic transfer of polymeric IgA from blood into bile.

1981 • 60 citations

Estimation of polymeric IgA in human serum: an assay based on binding of radiolabeled human secretory component with applications in the study of IgA nephropathy, IgA monoclonal gammopathy, and liver disease.

1983 • 60 citations

The biosynthesis of secretory component and its role in the transepithelial transport of IgA dimer

1985 • 60 citations

Serum Immunoglobulin Concentrations in Patients with Alcoholic Liver Disease

1969 • 60 citations

FUNCTION OF THE HUMAN LIVER IN IgA HOMEOSTASIS IN PLASMA*

1983 • 59 citations

Characteristics of serum IgA and liver IgA deposits in alcoholic liver disease

1987 • 59 citations

IgA glomerular deposits in experimental cirrhosis.

1981 • 58 citations

High serum levels of secretory IgA in liver disease

1982 • 57 citations

Detection of circulating immune complexes in alcoholic liver disease.

1978 • 56 citations

Distribution of secretory component in hepatocytes and its mode of transfer into bile

1980 • 55 citations

Immunohistologic Localization of Immunoglobulins, Secretory Component, and Lactoferrin in the Developing Human Fetus

1972 • 54 citations

Phosphorylation of the rat hepatic polymeric IgA receptor.

1986 • 54 citations

Interaction of rabbit secretory component with rabbit IgA dimer.

1979 • 54 citations

Studies on the origins of biliary immunoglobulins in rats

1984 • 54 citations

Dual nature of the hepatic lectin pathway for human asialotransferrin type 3 in the rat.

1982 • 53 citations

Demonstration of IgA and secretory component in human hepatocytes.

1980 • 52 citations

COMPARATIVE ASPECTS OF THE HEPATOBILIARY TRANSPORT OF IgA*

1983 • 52 citations

IgA plasma cells in biliary mucosa: a likely source of locally synthesized IgA in human hepatic bile.

1983 • 51 citations

Serum and intestinal secretory IgA in alcoholic cirrhosis of the liver.

1982 • 51 citations

Effect of colchicine on the transfer of IgA across hepatocytes into bile in isolated perfused rat livers

1980 • 50 citations

Selective transport of polymeric immunoglobulin a in bile

1983 • 49 citations

Immunoglobulins in Rabbit Hepatic Bile: Selective Secretion of IgA and IgM and Active Plasma‐to‐Bile Transfer of Polymeric IgA

1982 • 49 citations

Comparative aspects of the transport of immunoglobulin A from blood to bile.

1980 • 49 citations

Effect of aging on the hepatobiliary transport of dimeric immunoglobulin A in the male fischer rat

1985 • 49 citations

Carbohydrate-mediated clearance of secretory IgA from the circulation

1985 • 48 citations

Immunoglobulin A-mediated hepatobiliary transport constitutes a natural pathway for disposing of bacterial antigens

1983 • 47 citations

IgA Mesangial Nephropathy: Bergers Disease

1985 • 47 citations

Regulation of secretory component by glucocorticoids in primary cultures of rat hepatocytes.

1985 • 47 citations

IgA in alcoholic cirrhosis.

1983 • 47 citations

The biliary excretion of circulating asialoglycoproteins in the rat

1978 • 47 citations

Breast Milk IgA Binds to Jejunal Epithelium in Suckling Rats

1978 • 47 citations

Immunoglobulin-containing cells in the liver.

1969 • 46 citations

The Fate of Polymeric and Secretory Immunoglobulin A After Retrograde Infusion into the Common Bile Duct in Rats

1984 • 46 citations

Presence of J chain in human lymphoid cells.

1980 • 46 citations

Immunohistochemical Study of Secretory Component, Secretory IgA and Carcinoembryonic Antigen in Large Bowel Carcinomas

1980 • 45 citations

Estradiol regulation of secretory component in the uterus of the rat: evidence for involvement of RNA synthesis.

1984 • 44 citations

Binding, Uptake and Intracellular Processing of Polymeric Rat Immunoglobulin A by Cultured Rat Hepatocytes

1982 • 44 citations

Mechanisms of secretion of proteins into bile: Studies in the perfused rat liver

1986 • 44 citations

Alcoholic Liver Disease: An IgA-Associated Disorder

1987 • 43 citations

Structural and genetic heterogeneity of the receptor mediating translocation of immunoglobulin A dimer antibodies across epithelia in the rabbit.

1983 • 42 citations

Identification and Some Properties of Rat Secretory Component

1975 • 42 citations

The Liver: An Integral Part of the Enteric Mucosal Immune System

1982 • 42 citations

Secretory IgA in the serum of infants with obstructive jaundice

1980 • 40 citations

Functional expression of the polymeric immunoglobulin receptor from cloned cDNA in fibroblasts.

1986 • 40 citations

IgA ANTIBODY TO LIPID A IN ALCOHOLIC LIVER DISEASE

1986 • 40 citations

Serum immunoglobulin A changes in alcoholic patients.

1977 • 40 citations

A Comparative Study of the Biliary Secretion of Human Dimeric and Monomeric IgA in the Rat and in Man

1982 • 40 citations

Changes in IgA Following Varying Degrees of Biliary Obstruction in the Rat

1983 • 39 citations

Estradiol regulation of secretory component in the female reproductive tract

1981 • 39 citations

Patterns of IgA Deposition in Liver Tissues in Alcoholic Liver Disease

1982 • 39 citations

Hepatobiliary Clearance of IgA Immune Complexes Formed in the Circulation

2007 • 39 citations

Immunohistochemical Localization of Secretory Component in the Liver of Guinea Pigs and Dogs versus Rats, Rabbits, and Mice

1984 • 39 citations

Age-dependent loss of dimeric immunoglobulin A receptors in the liver of the Fischer 344 rat.

1985 • 39 citations

IgA in Blood and Thoracic Duct Lymph: Concentration and Degree of Polymerization

1978 • 39 citations

Dual role of the liver in regulating circulating polymeric IgA in man: studies on patients with liver disease.

1983 • 39 citations

The localization of the antibody response in milk or bile depends on the nature of the antigen.

1987 • 39 citations

Escherichia coliAntibodies in Alcoholic Liver Disease

1983 • 39 citations

Selective hepatobiliary transport of human polymeric IgA in mice

1984 • 38 citations

Helper and suppressor T lymphocyte function in severe alcoholic liver disease.

1985 • 38 citations

Binding of Secretory Component to Dimers of Immunoglobulin A in vitro

1976 • 38 citations

J chain is covalently bound to both monomer subunits in human secretory IgA.

1981 • 38 citations

IgA antibodies to dietary antigens in liver cirrhosis

1987 • 37 citations

Secretory component is covalently bound to a single sub-unit in human secretory IgA

1979 • 37 citations

Localization and Serum Concentration of Secretor Component During Massive Necrosis of Human Liver

1984 • 37 citations

Disulfide bonding of secretory component to a single monomer subunit in human secretory IgA.

1977 • 36 citations

Ontogenic changes in secretory component expression by villous and crypt cells of rat small intestine.

1985 • 36 citations

IgA antibodies in the bile of rats. I. Some characteristics of the primary response.

1982 • 34 citations

Preparation of a low-density species of endocytic vesicle containing immunoglobulin A

1983 • 34 citations

Transport of IgA antibody-antigen complexes by the rat liver

1981 • 33 citations

Elimination into bile of circulating antigen by endogenous IgA antibody in rats.

1982 • 33 citations

Specific antibody synthesis and biliary secretion by the rat liver after intestinal immunization with cholera toxin

1987 • 33 citations

Uptake and Intracellular Disposition of Iga by Rat Hepatocytes in Monolayer Culture

1982 • 32 citations

Presence and origin of IgA1- and IgA2-containing circulating immune complexes in chronic alcoholic liver diseases with and without glomerulonephritis

1985 • 32 citations

Selective immimoglobulin a deficiency associated with primary biliary cirrhosis in a family with liver disease

1986 • 32 citations

Effect of a disulfide-interchange enzyme on the assembly of human secretory immunoglobulin A from immunoglobulin A and free secretory component.

1979 • 31 citations

A functional homologue of mammalian secretory component exists in chickens

1983 • 31 citations

Studies of the transport of polyclonal IgA antibody from blood to bile in rats.

1980 • 30 citations

Serum IgM-bound secretory component (sIgM) in liver diseases: comparative molecular state of the secretory component in serum and bile.

1982 • 29 citations

Immunohistochemical localization of IgA and secretory component in rat liver

1980 • 29 citations

Synthesis of Secretory Component by Rat Hepatocytes in Culture

1980 • 28 citations

Rabbit secretory IgA: identification and genetic control of two allotypes of secretory component.

1974 • 28 citations

An immunofluorescent study of the distribution of immunoglobulin-containing cells in the normal and the inflamed human gall bladder

1972 • 28 citations

Ultrastructural immunocytochemical localization of the asialoglycoprotein receptor in rat hepatocytes

1984 • 27 citations

Immune elimination and enhanced antibody responses: functions of circulating IgA.

1980 • 27 citations

Spontaneous IgA Synthesis by Blood Mononuclear Cells in Alcoholic Liver Disease

1987 • 27 citations

Disulfide Bonding of Secretary Component to a Single Monomer Subunit in Human Secretory IgA

1977 • 26 citations

Gut and Bronchus Associated Lymphoid Tissue: An Overview

1982 • 26 citations

TRANSFER OF IgA INTO RAT BILE: ULTRASTRUCTURAL DEMONSTRATION

1983 • 26 citations

Rabbit Secretory IgA: Identification and Genetic Control of Two Allotypes of Secretory Component

1974 • 26 citations

IgA, Glomerulonephritis and Liver Disease

1981 • 25 citations

IgA Antibodies in Rat Bile Are Not Solely Derived from Thoracic Duct Lymph

1983 • 25 citations

Secretory component-dependent binding of immunoglobuin A in the rat, monkey and human: A comparison of intestine and liver

1987 • 25 citations

Characteristics of IgA Deposits in Liver and Skin of Patients with Liver Disease

1986 • 25 citations

Quantitative Study of the Uptake of IgA by Isolated Rat Hepatocytes

1981 • 25 citations

Dimeric Mouse IgA is Transported into Rat Bile Five Times More Rapidly than into Mouse Bile

1986 • 25 citations

IgA Deposition in Alcoholic Liver Disease: An Immunoelectron Microscopic Study

1988 • 25 citations

Neutralization of cholera toxin by rat bile secretory IgA antibodies.

1985 • 24 citations

Occurrence of specific secretory immunoglobulin A in bile after inoculation of Giardia lamblia trophozoites into rat duodenum.

1984 • 24 citations

Binding of Secretory Component to Dimers of Immunoglobulin A in vitro

1974 • 23 citations

Effect of air ions on healing of wounds of rat skin

1986 • 23 citations

Primary cultures of rat hepatocytes as a model system of canalicular development, biliary secretion, and intrahepatic cholestasis. III. Properties of the biliary transport of immunoglobulin A revealed by immunofluorescence.

1983 • 23 citations

IgA deposition in alcoholic liver disease.

1986 • 22 citations

Recent advances in mucosal immunity

1983 • 22 citations

Interaction of rat IgA with cultured rat hepatocytes: binding site, drug effects

1980 • 22 citations

Cholelithiasis in Children with Immunoglobulin A Deficiency

1983 • 21 citations

DIFFERENCES IN PROCESSING OF POLYMERIC IgA AND ASIALOGLYCOPROTEINS BY THE RAT LIVER*

1983 • 21 citations

IgA deposition in liver in alcoholic liver disease. An index of progressive injury.

1984 • 21 citations

Gall bladder: the predominant source of bile IgA in man?

1985 • 21 citations

Secretory component as the mucosal transport receptor: Separation of physicochemically analogous human iga fractions with different receptor-binding capacities

1986 • 21 citations

A Comparison of Secretory Component — Immunoglobulin Interactions Amongst Different Species

1978 • 21 citations

Cellular distribution of the asialoglycoprotein receptor in rat liver

1984 • 21 citations

The importance of the Fc receptors for IgA in the recognition of IgA by mouse liver cells: its comparison with carbohydrate and secretory component receptors.

1986 • 21 citations

Association of S-IgA Subunits

1974 • 21 citations

IgA Subclasses in Liver Tissues in Alcoholic Liver Disease

1983 • 21 citations

Serum levels of secretory immunoglobulin A in liver disease.

1985 • 20 citations

Occurrence of Specific Secretory immunoglobulin A in Bile After Inoculation of Giardia lamblia Trophozoites Into Rat Duodenum

1984 • 20 citations

Antibody Synthesis in the Rat Liver: An Association between Antibody-Forming Cells in the Liver and Biliary Antibodies following Intravenous Injection of Horse Erythrocytes

1987 • 20 citations

Measurement of Secretory IgA in Serum by Radioimmunoassay in Patients with Chronic Nonalcoholic Liver Disease or Carcinoma

1984 • 20 citations

Primary cultures of rat hepatocytes as a model system of canalicular development, biliary secretion, and intrahepatic cholestasis

1983 • 20 citations

Complexes of serum gamma-glutamyltransferase with apolipoproteins and immunoglobulin A.

1984 • 19 citations

IgA antibodies in the bile of rats. III. The role of intrathoracic lymph nodes and the migration pattern of their blast cells.

1983 • 19 citations

A search for an enriched source of polymeric IgA in human thoracic duct lymph, portal vein blood and aortic blood.

1982 • 19 citations

High and low molecular weight rabbit secretory components. Evidence for the deletion of the second and third domains in the smaller polypeptide.

1987 • 19 citations

Effects of monensin on vesicular transport pathways in the perfused rat liver

1986 • 19 citations

Rat liver membrane secretory component is larger than free secretory component in bile: Evidence for proteolytic conversion of membrane form to free form

1984 • 19 citations

Value of serum immunoglobulins in the diagnosis of liver disease

1984 • 19 citations

IgA antibodies in the bile of rats. II. Evidence for immunological memory in secretory immunity.

1982 • 19 citations

Distribution and processing of the polymeric immunoglobulin receptor in the rat hepatocyte: morphological and biochemical characterization of subcellular fractions.

1986 • 18 citations

IgA-mediated elimination of antigens by the hepatobiliary route.

1983 • 18 citations

IgA antibodies in rat bile inhibit cholera toxin-induced secretion in ileal loops in situ.

1985 • 17 citations

Characteristics of the complex between alkaline phosphatase and immunoglobulin A in human serum

1985 • 17 citations

IMMUNOFLUORESCENT AND IMMUNOCYTOCHEMICAL LOCALIZATION OF SECRETORY COMPONENT AND IMMUNOGLOBULINS IN HUMAN LIVER

1983 • 17 citations

Biliary transport of serum IgA in sheep.

1984 • 16 citations

Antibodies to Escherichia coli and Anti‐Adhesive Activity in Paired Serum, Hepatic and Gall Bladder Bile Samples

1986 • 16 citations

Circulating secretory immunoglobulins of the A and M isotypes in chronic liver disease

1987 • 15 citations

IgA Mesangial Nephropathy

2015 • 15 citations

Analysis of the hepatobiliary transport of IgA with monoclonal anti-idiotype and anti-allotype antibodies

1986 • 15 citations

Intracellular processing of human vs. rat immunoglobulin A in the rat liver

1985 • 15 citations

Cellular Sites of Immunoglobulins

1974 • 14 citations

Posttranslational processing of secretory component in the rat jejunum by a brush border metalloprotease.

1986 • 14 citations

Immune responses of rats to live Vibrio cholerae: secretion of antibodies in bile

1981 • 14 citations

Possible mechanisms of elevation of serum secretory immunoglobulin A in liver diseases.

1986 • 14 citations

The occurrence of secretory IgM in the bile of rats.

1983 • 14 citations

Alterations in protein transport events in rat liver after estrogen treatment

1987 • 13 citations

Intracellular transport and processing of secretory component in cultured rat hepatocytes

1987 • 13 citations

The effect of lactation on the transport of serum-derived IgA into bile of sheep.

1985 • 13 citations

Induction of secretory component synthesis in colonic epithelial cells.

1987 • 12 citations

The Induction and Expression of IgA Anti‐DNP Antibodies in Rat Bile and Secretions

1981 • 12 citations

Cellular Sites of Immunoglobulins

1974 • 12 citations

RELATIVE RATES OF THE NON-COVALENT AND COVALENT BINDING OF SECRETORY COMPONENT TO AN IgA DIMER

1977 • 11 citations

Gastrointestinal uptake and blood clearance of antigen in the presence of IgA antibodies.

1983 • 11 citations

Molecular diversity of secretory IgA anti-DNP antibodies elicited in rat bile.

1980 • 11 citations

Glomerular Disease in Cirrhosis of the Liver: Low Frequency of IgA Deposits

1986 • 11 citations

Ligand-dependent redistribution of the IgA receptor on cultured rat hepatocytes and its disturbance by cytochalasin B.

1987 • 11 citations

FUNCTION AND BIOSYNTHESIS OF POLYMERIC IgA*

1983 • 11 citations

infection in the rat: 1. Production of bile lgA and serum lgG antibodies by adult rats

1981 • 10 citations

Immunoglobulins and antibodies in gallbladder bile.

1970 • 10 citations

GLOMERULAR DEPOSITION OF IgA IN EXPERIMENTAL HEPATIC CIRRHOSIS

1985 • 10 citations

Gut-Liver Interactions in the IgA System

1985 • 9 citations

Increased Serum Antibody Levels Against Cow's Milk Proteins in Children With Chronic Liver Disease

1985 • 9 citations

Hepatic Production of Biliary IgM in the Rat

1986 • 8 citations

HEPATIC UPTAKE AND TRANSFER INTO BILE OF POLYMERIC IgA, ANTI‐SECRETORY COMPONENT IgG, HAPTOGLOBIN‐HEMOGLOBIN COMPLEX, GALACTOSYLATED SERUM ALBUMIN, AND HORSERADISH PEROXIDASE: A COMPARATIVE BIOCHEMICAL STUDY IN THE RAT

1983 • 8 citations

Serum secretory IgA, IgA1 and IgA2 subclasses in inflammatory bowel and chronic liver diseases.

1987 • 7 citations

Immunoglobulin A stimulates growth of the extrahepatic bile duct in BALB/c mice.

1987 • 6 citations

Handling of IgA Immune Aggregates by Liver Cells

2015 • 5 citations

A comparison of IgA in portal and peripheral venous blood.

1987 • 4 citations

INTESTINAL ANTIBODIES IN RATS FOLLOWING EXPOSURE TO LIVE VIBRIO CHOLERAE

1984 • 4 citations

In vitro uptake of IgA complexes by Kupffer cells

1983 • 4 citations

Antibody synthesis in the rat liver: a source of biliary IgM, IgA and IgG following injection of horse erythrocytes into the intestine or Peyer's patches.

1987 • 4 citations

Enterohepatic circulation of IgA does not occur in rats

1981 • 3 citations

Detection of Food Antigen-Specific IgA Immune Complexes in Human Sera

1987 • 3 citations

Synthesis of cytoplasmic and functional membrane SC induced by gamma-interferon.

1987 • 2 citations

Biliary IgA content following common duct cannulation in the rat.

1987 • 2 citations

Immunoglobulin content of human hepatic bile: selective IgA concentration in bile.

1986 • 1 citations