Activation of protein kinase C alters voltage dependence of a Na+ channel

A quantitative description of membrane current and its application to conduction and excitation in nerve

1952 • 21,965 citations

Ionic channels of excitable membranes

1985 • 7,199 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

Ionic Channels of Excitable Membranes

1985 • 3,014 citations

Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals

1972 • 1,861 citations

Inactivation of the sodium channel. I. Sodium current experiments.

1977 • 1,509 citations

PROTEIN SERINE/THREONINE KINASES

1987 • 1,457 citations

Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence

1984 • 1,339 citations

Structural parts involved in activation and inactivation of the sodium channel

1989 • 1,189 citations

Structure and Function of Voltage-Sensitive Ion Channels

1988 • 1,171 citations

Inactivation of the sodium channel. II. Gating current experiments.

1977 • 943 citations

Existence of distinct sodium channel messenger RNAs in rat brain

1986 • 909 citations

A reinterpretation of mammalian sodium channel gating based on single channel recording

1983 • 675 citations

The Use ofXenopusOocytes for the Study of Ion Channel

1987 • 649 citations

Negative surface charge near sodium channels of nerve: divalent ions, monovalent ions, and pH

1975 • 599 citations

Expression of functional sodium channels from cloned cDNA

1986 • 537 citations

Molecular model of the action potential sodium channel.

1986 • 525 citations

Ionic Channels and Their Regulation by G Protein Subunits

1990 • 413 citations

Gating currents and charge movements in excitable membranes

2006 • 405 citations

A rat brain na+ channel α subunit with novel gating properties

1988 • 359 citations

Differential regulation of three sodium channel messenger RNAs in the rat central nervous system during development.

1989 • 356 citations

Modulation of ion channel activity: a key function of the protein kinase C enzyme family.

1989 • 338 citations

Neuromodulation : the biochemical control of neuronal excitability

1987 • 237 citations

β-Adrenergic Inhibition of Cardiac Sodium Channels by Dual G-Protein Pathways

1989 • 232 citations

DNA sequences preceding the rabbit beta-globin gene are required for formation in mouse L cells of beta-globin RNA with the correct 5' terminus.

1981 • 231 citations

Biosynthesis and processing of the α subunit of the voltage-sensitive sodium channel in rat brain neurons

1986 • 208 citations

Activation of protein kinase C differentially modulates neuronal Na+, Ca2+, and gamma-aminobutyrate type A channels.

1988 • 197 citations

Activation of protein kinase C induces rapid internalization and subsequent degradation of muscarinic acetylcholine receptors in neuroblastoma cells.

1986 • 194 citations

The structure of the voltage‐sensitive sodium channel

1985 • 193 citations

A neutral amino acid change in segment IIS4 dramatically alters the gating properties of the voltage-dependent sodium channel.

1990 • 186 citations

Expression and Modulation of Voltage-Gated Calcium Channels After RNA Injection in Xenopus Oocytes

1986 • 174 citations

Cyclic AMP-dependent phosphorylation of the alpha subunit of the sodium channel in synaptic nerve ending particles.

1984 • 169 citations

Neuromodulation: The Biochemical Control of Neuronal Excitability

1988 • 166 citations

Fast and slow gating of sodium channels encoded by a single mRNA

1990 • 162 citations

Xenopus oocyte resting potential, muscarinic responses and the role of calcium and guanosine 3',5'‐cyclic monophosphate.

1984 • 153 citations

Probing the Molecular Structure of the Voltage-Dependent Sodium Channel

1988 • 140 citations

Two calcium‐activated chloride conductances in Xenopus laevis oocytes permeabilized with the ionophore A23187.

1989 • 130 citations

Sodium channel gating in clonal pituitary cells. The inactivation step is not voltage dependent.

1989 • 118 citations

Phosphorylation of the? subunit of the sodium channel by protein kinase C

1984 • 111 citations

Identification of an intracellular domain of the sodium channel having multiple cAMP-dependent phosphorylation sites.

1987 • 106 citations

Cyclic-AMP-dependent phosphorylation of voltage-sensitive sodium channels in primary cultures of rat brain neurons.

1987 • 105 citations

Functional Properties of Rat Brain Sodium Channels Expressed in a Somatic Cell Line

1990 • 104 citations

Evidence for the involvement of more than one mRNA species in controlling the inactivation process of rat and rabbit brain Na channels expressed in Xenopus oocytes

1988 • 97 citations

cis‐Fatty acids, which activate protein kinase C, attenuate Na+ and Ca2+ currents in mouse neuroblastoma cells.

1989 • 95 citations

Heterologous Expression of Excitability Proteins: Route to More Specific Drugs?

1988 • 95 citations

Inactivation of cloned Na channels expressed in Xenopus oocytes.

1990 • 89 citations

Phosphorylation of the α Subunit of Rat Brain Sodium Channels by cAMP-dependent Protein Kinase at a New Site Containing Ser686 and Ser687

1989 • 66 citations

Protein kinase C modulates neurotransmitter responses in Xenopus oocytes injected with rat brain RNA

1989 • 61 citations

Modulation of vertebrate brain Na⁺ and K⁺ channels by subtypes of protein kinase C

1990 • 53 citations

Software for electrophysiological experiments with a personal computer

1985 • 48 citations

Tetrodotoxin-sensitive sodium current in native Xenopus oocytes

1987 • 31 citations

Use-dependent block of sodium channels in frog myelinated nerve by tetrodotoxin and saxitoxin at negative holding potentials

1989 • 25 citations

Blockade of ion channel expression in xenopus oocytes with complementary DNA probes to Na+ and K+ channel mRNAs

1988 • 19 citations

Expression of functional sodium channels in stage II–III Xenopus oocytes

1989 • 17 citations

Modulation of the voltage-dependent sodium channel by agents affecting G-proteins: a study in Xenopus oocytes injected with brain RNA

1989 • 16 citations

Modification of the Na-dependent action potential in myelinated fibers of rat sciatic nerve exposed to phorbol ester

1989 • 5 citations