The Plant Isoflavenoid Genistein Activates p53 and Chk2 in an ATM-dependent Manner

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

1987 • 3,773 citations

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

1995 • 2,767 citations

Caspases: killer proteases

1997 • 2,440 citations

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

1998 • 2,034 citations

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1993 • 1,888 citations

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

1998 • 1,734 citations

Soy intake and cancer risk: A review of thein vitroandin vivodata

1994 • 1,330 citations

Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase

1998 • 1,314 citations

A role for ATR in the DNA damage-induced phosphorylation of p53

1999 • 1,043 citations

Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.

1999 • 1,032 citations

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

2000 • 807 citations

Radiosensitivity in ataxia-telangiectasia: a new explanation.

1980 • 784 citations

Dietary effects on breast-cancer risk in Singapore

1991 • 782 citations

DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1995 • 742 citations

THE GENETIC DEFECT IN ATAXIA-TELANGIECTASIA

1997 • 637 citations

Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death.

1996 • 621 citations

Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo.

1998 • 601 citations

Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II.

1989 • 559 citations

Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

1997 • 542 citations

The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species

1995 • 540 citations

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

1998 • 533 citations

ATM associates with and phosphorylates p53: mapping the region of interaction

1998 • 494 citations

Interaction between ATM protein and c-Abl in response to DNA damage

1997 • 481 citations

Human DNA-Activated Protein Kinase Phosphorylates Serines 15 and 37 in the Amino-Terminal Transactivation Domain of Human p53

1992 • 473 citations

Dietary phytoestrogens and cancer: in vitro and in vivo studies

1992 • 435 citations

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

1999 • 425 citations

DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis.

1995 • 422 citations

Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen.

1990 • 415 citations

The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents.

1993 • 403 citations

DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis.

1996 • 351 citations

Induction of apoptosis in breast cancer cells MDA-MB-231 by genistein

1999 • 317 citations

When is a lipid kinase not a lipid kinase? When it is a protein kinase

1995 • 315 citations

DNA-dependent protein kinase acts upstream of p53 in response to DNA damage

1998 • 313 citations

Caffeine inhibits the checkpoint kinase ATM

1999 • 293 citations

The DNA-dependent Protein Kinase Is Inactivated by Autophosphorylation of the Catalytic Subunit

1996 • 287 citations

Caffeine Abolishes the Mammalian G2/M DNA Damage Checkpoint by Inhibiting Ataxia-Telangiectasia-mutated Kinase Activity

2000 • 278 citations

ATM-related genes: What do they tell us about functions of the human gene?

1995 • 276 citations

Flavonoids as DNA Topoisomerase Antagonists and Poisons: Structure-Activity Relationships

1995 • 269 citations

Effect of ionizing radiation on DNA synthesis in ataxia telangiectasia cells

1980 • 260 citations

Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells.

1993 • 253 citations

Neonatal Genistein Chemoprevents Mammary Cancer

1995 • 247 citations

The role of ATM in DNA damage responses and cancer

1998 • 165 citations

The MEK Pathway Is Required for Stimulation of p21WAF1/CIP1 by Transforming Growth Factor-β

1999 • 160 citations

The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53

1999 • 127 citations

DNA-dependent Protein Kinase Interacts with Antigen Receptor Response Element Binding Proteins NF90 and NF45

1998 • 123 citations

Purification and Characterization of ATM from Human Placenta

2000 • 122 citations

Genistein Induces Apoptosis in Immature Human Thymocytes by Inhibiting Topoisomerase-II

1993 • 113 citations

Cleavage and Inactivation of ATM during Apoptosis

1999 • 104 citations

Effects of genistein and structurally related phytoestrogens on cell cycle kinetics and apoptosis in MDA-MB-468 human breast cancer cells.

2000 • 103 citations

Suppression of tumour development by substances derived from the diet—mechanisms and clinical implications

1998 • 103 citations

Distinct Chk2 Activation Pathways Are Triggered by Genistein and DNA-damaging Agents in Human Melanoma Cells

2000 • 59 citations

ATM: the p53 booster

1998 • 39 citations

p56/p53lyn tyrosine kinase activation in mammalian cells treated with mitomycin C.

1994 • 33 citations

Tyrosine Kinase Inhibition Affects Type 1 Angiotensin II Receptor Intern Alization

1999 • 13 citations