Evolution of the intron-exon structure of eukaryotic genes

Why genes in pieces?

1978 • 2,256 citations

Nuclear volume control by nucleoskeletal DNA, selection for cell volume and cell growth rate, and the solution of the DNA C-value paradox

1978 • 681 citations

Speculations on RNA splicing

1981 • 639 citations

STRUCTURE AND ACTIVITIES OF GROUP II INTRONS

1995 • 569 citations

THE MULTIPLICITY OF DOMAINS IN PROTEINS

1995 • 512 citations

Evolution of the proteases of blood coagulation and fibrinolysis by assembly from modules

1985 • 492 citations

Genes in pieces: were they ever together?

1978 • 440 citations

The Exon Theory of Genes

1987 • 395 citations

Correlation of DNA exonic regions with protein structural units in haemoglobin

1981 • 394 citations

Splicing signals inDrosophila: intron size, information content, and consensus sequences

1992 • 380 citations

Intron phylogeny: a new hypothesis

1991 • 361 citations

On the antiquity of introns

1986 • 324 citations

Intron‐dependent evolution: Preferred types of exons and introns

1987 • 300 citations

Do genes-in-pieces imply proteins-in-pieces?

1978 • 287 citations

Introns: evolution and function

1994 • 279 citations

Intron phase correlations and the evolution of the intron/exon structure of genes.

1995 • 270 citations

Features of spliceosome evolution and function inferred from an analysis of the information at human splice sites

1992 • 268 citations

The recent origins of introns

1991 • 263 citations

Evidence that introns arose at proto-splice sites.

1989 • 235 citations

How Big Is the Universe of Exons?

1990 • 228 citations

Alternative mRNA Splicing

1992 • 219 citations

Split-gene evolution: Exon shuffling and intron insertion in serine protease genes

1985 • 217 citations

Testing the Exon Theory of Genes: The Evidence from Protein Structure

1994 • 217 citations

RNA-RNA interactions in the spliceosome: Unraveling the ties that bind

1994 • 208 citations

The triosephosphate isomerase gene from maize introns antedate the plant-animal divergence

1986 • 188 citations

Cassette of Eight Exons Shared by Genes for LDL Receptor and EGF Precursor

1985 • 185 citations

Ancient Conserved Regions in New Gene Sequences and the Protein Databases

1993 • 179 citations

Modular exchange principles in proteins

1991 • 169 citations

Structure of a Plasma Membrane H+-ATPase Gene from the Plant Arabidopsis thaliana

1989 • 166 citations

Genes encoding actin in higher plants: intron positions are highly conserved but the coding sequences are not.

1983 • 160 citations

On the ancient nature of introns

1993 • 140 citations

The structure of a chromosomal leghaemoglobin gene from soybean

1981 • 132 citations

How were introns inserted into nuclear genes?

1989 • 131 citations

The gene for the U6 small nuclear RNA in fission yeast has an intron

1989 • 126 citations

Five identical intron positions in ancient duplicated genes of eubacterial origin

1994 • 110 citations

Three Different Rearrangements in a Single Intron Truncate Sterol Regulatory Element Binding Protein-2 and Produce Sterol-resistant Phenotype in Three Cell Lines

1995 • 96 citations

mRNA-type introns in U6 small nuclear RNA genes: implications for the catalysis in pre-mRNA splicing.

1991 • 96 citations

De novo synthesis of an intron by the maize transposable element Dissociation.

1994 • 95 citations

Information content ofCaenorhabditis eleganssplice site sequences varies with intron length

1990 • 85 citations

Exon—intron organization of the Arabidopsis thaliana protein kinase genes CDC2a and CDC2b

1992 • 77 citations

Exons – original building blocks of proteins?

1991 • 72 citations

Genetic engineering in the Precambrian: structure of the chicken triosephosphate isomerase gene.

1985 • 64 citations

Genetic and Biochemical Analysis of Alternative RNA Splicing

1994 • 63 citations

Intron loss from the NADH dehydrogenase subunit 4 gene of lettuce mitochondrial DNA: evidence for homologous recombination of a cDNA intermediate

1994 • 54 citations

A novel intron site in the triosephosphate isomerase gene from the mosquito Culex tarsalis

1993 • 49 citations

INTRONS AND EXONS: PLAYGROUNDS OF EVOLUTION

1979 • 48 citations

Homologous domains of the largest subunit of eucaryotic RNA polymerase II are conserved in plants

1990 • 46 citations

Histone genes ofVolvox carteri: DNA sequence and organization of two H3-H4 gene loci

1988 • 41 citations

Structural organization of the mouse aspartate aminotransferase isoenzyme genes

1988 • 38 citations

The limited universe of exons

1991 • 38 citations

Structural organization of the mouse cytosolic malate dehydrogenase gene: Comparison with that of the mouse mitochondrial malate dehydrogenase gene

1988 • 37 citations

Compartmentalized isozyme genes and the origin of introns

1990 • 30 citations

Structure of the Drosophila melanogaster Glutathione‐Dependent Formaldehyde Dehydrogenase/Octanol Dehydrogenase Gene (Class III Alcohol Dehydrogenase)

1994 • 25 citations

An mRNA-Type Intron Is Present in the Rhodotorula hasegawae U2 Small Nuclear RNA Gene

1993 • 22 citations

Exon shuffling in anther-specific genes from sunflower

1994 • 17 citations

The limited universe of exons

1991 • 12 citations