Evidence that introns arose at proto-splice sites.

A catalogue of splice junction sequences

1982 • 3,861 citations

Why genes in pieces?

1978 • 2,256 citations

The nucleotide sequence of the rat cytoplasmic β–actin gene

1983 • 1,059 citations

Molecular structure of the human cytoplasmic beta-actin gene: interspecies homology of sequences in the introns.

1985 • 706 citations

Cloning and characterization of the gene for beta-tubulin from a benomyl-resistant mutant of Neurospora crassa and its use as a dominant selectable marker.

1986 • 518 citations

Evolution of the proteases of blood coagulation and fibrinolysis by assembly from modules

1985 • 492 citations

On the origin of RNA splicing and introns

1985 • 483 citations

The NDA3 gene of fission yeast encodes β-tubulin: A cold-sensitive nda3 mutation reversibly blocks spindle formation and chromosome movement in mitosis

1984 • 473 citations

Structure of a split yeast gene: complete nucleotide sequence of the actin gene in Saccharomyces cerevisiae.

1980 • 410 citations

The nucleotide sequence of the chick cytoplasmic β-actin gene

1983 • 336 citations

On the antiquity of introns

1986 • 324 citations

The actin genes of drosophila: Protein coding regions are highly conserved but intron positions are not

1981 • 322 citations

Intron‐dependent evolution: Preferred types of exons and introns

1987 • 300 citations

Evolutionary history of a multigene family: An expressed human β-tubulin gene and three processed pseudogenes

1983 • 287 citations

Speculations on the early course of evolution.

1986 • 284 citations

The sequences of an expressed rat α-tubulin gene and a pseudogene with an inserted repetitive element

1982 • 260 citations

Signals for the selection of a splice site in pre-mRNA

1987 • 247 citations

Split-gene evolution: Exon shuffling and intron insertion in serine protease genes

1985 • 217 citations

Identification of the pleiotropic cell division cycle gene NDA2 as one of two different α-tubulin genes in schizosaccharomyces pombe

1984 • 216 citations

Aspergillus nidulans contains a single actin gene which has unique intron locations and encodes a γ-actin

1988 • 209 citations

Nucleotide sequence of the rat skeletal muscle actin gene

1982 • 207 citations

5′ cleavage site in eukaryotic pre-mRNA splicing is determined by the overall 5′ splice region, not by the conserved 5′ GU

1987 • 206 citations

Complete nucleotide sequence of a soybean actin gene

1982 • 197 citations

The two beta-tubulin genes of Chlamydomonas reinhardtii code for identical proteins.

1984 • 189 citations

The complete nucleotide sequence of the chick a-actin gene and its evolutionary relationship to the actin gene family

1982 • 183 citations

The two alpha-tubulin genes of Chlamydomonas reinhardi code for slightly different proteins.

1985 • 181 citations

Tissue-specific and constitutive alpha-tubulin genes of Drosophila melanogaster code for structurally distinct proteins.

1986 • 157 citations

Actin gene family of Caenorhabditis elegans

1983 • 156 citations

Aspergillus nidulans β-tubulin genes are unusually divergent

1987 • 152 citations

The α- and β-tubulins of Toxoplasma gondii are encoded by single copy genes containing multiple introns

1988 • 152 citations

Upstream sequences required for tissue-specific activation of the cardiac actin gene in Xenopus laevis embryos.

1986 • 144 citations

Tubulin genes of the African trypanosome Trypanosoma brucei rhodesiense: nucleotide sequence of a 3.7-kb fragment containing genes for alpha and beta tubulins

1985 • 135 citations

Three expressed sequences within the human β-tubulin multigene family each define a distinct isotype

1985 • 134 citations

Cloning and Characterization of the Gene for β-Tubulin from a Benomyl-Resistant Mutant of Neurospora crassa and Its Use as a Dominant Selectable Marker

1986 • 112 citations

Sequence of one α- and two β-tubulin genes of Tetrahymena pyriformis

1988 • 100 citations

Actin genes and actin messenger RNA in Acanthamoeba castellanii

1982 • 98 citations

The Complete Sequence of the Mouse Skeletal α-Actin Gene Reveals Several Conserved and Inverted Repeat Sequences Outside of the Protein-Coding Region

1986 • 96 citations

Sequence of an expressed human β-tubulin gene containing tenAlufamily members

1984 • 94 citations

Complete nucleotide sequence of a sea urchin actin gene

1982 • 94 citations

Structure of a human smooth muscle actin gene (aortic type) with a unique intron site.

1984 • 91 citations

Isolation of actin genes in Bombyx mori: The coding sequence of a cytoplasmic actin gene expressed in the silk gland is interrupted by a single intron in an unusual position

1986 • 90 citations

Nucleotide sequence of an actin gene from Arabidopsis thaliana

1988 • 86 citations

Novel chicken actin gene: third cytoplasmic isoform.

1985 • 82 citations

The Two β-Tubulin Genes of Chlamydomonas reinhardtii Code for Identical Proteins

1984 • 74 citations

The Two Alpha-Tubulin Genes of Chlamydomonas reinhardi Code for Slightly Different Proteins

1985 • 74 citations

Isolation and characterization of a β-tubulin gene from Candida albicans

1988 • 73 citations

The complete sequence of the chicken α-cardiac actin gene: a highly conserved vertebrate gene

1985 • 73 citations

Structure of chick chromosomal genes for calbindin and calretinin

1988 • 72 citations

Sequence of a highly divergent beta tubulin gene reveals regional heterogeneity in the beta tubulin polypeptide.

1984 • 68 citations

Organization and structure of Volvox β-tubulin genes

1988 • 67 citations

Structural features and restricted expression of a human α-tubulin gene

1985 • 63 citations

Sequence and expression of the chicken beta 5- and beta 4-tubulin genes define a pair of divergent beta-tubulins with complementary patterns of expression.

1986 • 61 citations

Alternative 5′ exons either provide or deny an initiator methionine codon to the same α-tubulin coding region

1987 • 57 citations

Primary structure of an α-tubulin gene of Physarum polycephalum

1987 • 50 citations

A survey of the alpha-tubulin gene family in chicken: unexpected sequence heterogeneity in the polypeptides encoded by five expressed genes.

1988 • 48 citations

The sequence of a sea urchin muscle actin gene suggests a gene conversion with a cytoskeletal actin gene

1987 • 39 citations

Novel Chicken Actin Gene: Third Cytoplasmic Isoform

1985 • 36 citations

In vitrosplicing of mRNA precursors: 5' cleavage site can be predicted from the interaction between the 5' splice region and the 5' terminus of U1 snRNA

1988 • 32 citations

A putative ancestral actin gene present in a thermophilic eukaryote: novel combination of intron positions

1988 • 30 citations

Structure of Physarum actin gene locus ardA: a nonpalindromic sequence causes inviability of phage lambda and recA-independent deletions

1986 • 23 citations

Structure and expression of an actin gene of Physarum polycephalum

1988 • 19 citations

Sequence and Expression of the Chicken β5- and β4-Tubulin Genes Define a Pair of Divergent β-Tubulins with Complementary Patterns of Expression

1986 • 15 citations