Antagonistic Variant Virus Prevents Wild-type Virus-induced Lethal Immunopathology

J. Virol. Methods

1996 • 2,573 citations

Encephalitogenic potential of the myelin basic protein peptide (amino acids 83–99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand

2000 • 805 citations

Altered Peptide Ligand–Induced Partial T Cell Activation: Molecular Mechanisms and Role in T Cell Biology

1996 • 698 citations

Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells

1993 • 595 citations

Separation of IL-4 Production from Th Cell Proliferation by an Altered T Cell Receptor Ligand

1991 • 565 citations

Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells

1994 • 545 citations

ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists

1995 • 510 citations

Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial

2000 • 506 citations

Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor

1992 • 501 citations

Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates

1991 • 460 citations

An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis

1995 • 422 citations

Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants

1994 • 418 citations

Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein

1996 • 389 citations

Virus-specific major MHC class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection

1998 • 380 citations

Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes

1998 • 354 citations

Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling.

1993 • 238 citations

Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon gamma and tumor necrosis factor alpha production.

1994 • 216 citations

Critical Role for Alpha/Beta and Gamma Interferons in Persistence of Lymphocytic Choriomeningitis Virus by Clonal Exhaustion of Cytotoxic T Cells

2001 • 177 citations

Bystander Activation of Cytotoxic T Cells: Studies on the Mechanism and Evaluation of In Vivo Significance in a Transgenic Mouse Model

1997 • 176 citations

Comparison of Activation versus Induction of Unresponsiveness of Virus-Specific CD4+ and CD8+ T Cells upon Acute versus Persistent Viral Infection

1998 • 159 citations

Aplastic Anemia Rescued by Exhaustion of Cytokine-secreting CD8+ T Cells in Persistent Infection with Lymphocytic Choriomeningitis Virus

1998 • 142 citations

Hepatitis C virus variants circumventing cytotoxic T lymphocyte activity as a mechanism of chronicity

1998 • 141 citations

Persistence of lymphocytic choriomeningitis virus at very low levels in immune mice

1999 • 112 citations

Impairment of Cd4+ T Cell Responses during Chronic Virus Infection Prevents Neutralizing Antibody Responses against Virus Escape Mutants

2001 • 91 citations

CD4+ T-cell–epitope escape mutant virus selected in vivo

2001 • 80 citations

Viral escape at the molecular level explained by quantitative T-cell receptor/peptide/MHC interactions and the crystal structure of a peptide/MHC complex

2000 • 47 citations

Design of high-affinity major histocompatibility complex-specific antagonist peptides that inhibit cytotoxic T-lymphocyte activity: implications for control of viral disease

1992 • 42 citations

The Role of Proinflammatory Cytokines in Wasting Disease During Lymphocytic Choriomeningitis Virus Infection

2002 • 37 citations

Functional in vivo MHC class II loading by endogenously synthesized glycoprotein during viral infection.

1997 • 28 citations

Immunology - Promethean Viruses

1994 • 15 citations