Viral escape at the molecular level explained by quantitative T-cell receptor/peptide/MHC interactions and the crystal structure of a peptide/MHC complex

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1997 • 33,348 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

Calculation of protein extinction coefficients from amino acid sequence data

1989 • 5,198 citations

AMoRe: an automated package for molecular replacement

1994 • 4,990 citations

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

Satisfying Hydrogen Bonding Potential in Proteins

1994 • 2,076 citations

SETOR: Hardware-lighted three-dimensional solid model representations of macromolecules

1993 • 1,295 citations

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

1995 • 1,143 citations

Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 Å resolution

1991 • 1,079 citations

The Immunological Synapse

2001 • 987 citations

LIGAND RECOGNITION BY αβ T CELL RECEPTORS

1998 • 904 citations

Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.

1989 • 778 citations

Altered Peptide Ligand–Induced Partial T Cell Activation: Molecular Mechanisms and Role in T Cell Biology

1996 • 698 citations

Immunology Taught by Viruses

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Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

1990 • 558 citations

Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells

1994 • 545 citations

STRUCTURAL BASIS OF T CELL RECOGNITION

1999 • 518 citations

Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy.

1996 • 452 citations

THE DYNAMICS OF T CELL RECEPTOR SIGNALING: Complex Orchestration and the Key Roles of Tempo and Cooperation

1999 • 439 citations

Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants

1994 • 418 citations

The Crystal Structure of a T Cell Receptor in Complex with Peptide and MHC Class II

1999 • 400 citations

From TCR Engagement to T Cell Activation

1999 • 379 citations

Four A6-TCR/Peptide/HLA-A2 Structures that Generate Very Different T Cell Signals Are Nearly Identical

1999 • 366 citations

Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes

1998 • 354 citations

Lower receptor avidity required for thymic clonal deletion than for effector T-cell function

1991 • 263 citations

The three-dimensional structure of H-2Db at 2.4 Å resolution: Implications for antigen-determinant selection

1994 • 243 citations

A Functional Hot Spot for Antigen Recognition in a Superagonist TCR/MHC Complex

2000 • 204 citations

Mature T cell reactivity altered by peptide agonist that induces positive selection.

1996 • 148 citations

T Cell Responses and Viral Escape

1998 • 145 citations

Antagonist HIV-1 Gag Peptides Induce Structural Changes in HLA B8

1996 • 135 citations

Crystal Structures of Two H-2Db/Glycopeptide Complexes Suggest a Molecular Basis for CTL Cross-Reactivity

1999 • 122 citations

T cell responses are governed by avidity and co‐stimulatory thresholds

1996 • 107 citations

Tolerance induction by clonal deletion of CD4⁺8⁺ thymocytes in vitro does not require dedicated antigen‐presenting cells

1993 • 97 citations

Peptide‐induced T cell receptor down‐regulation on naive T cells predicts agonist/partial agonist properties and strictly correlates with T cell activation

1997 • 89 citations

Structural Evidence of T Cell Xeno-reactivity in the Absence of Molecular Mimicry

1999 • 85 citations

CTL Escape Viral Variants

1995 • 83 citations

Antagonism of cytotoxic T lymphocyte‐mediated lysis by natural HIV‐1 altered peptide ligands requires simultaneous presentation of agonist and antagonist peptides

1997 • 69 citations

Cytotoxic T‐lymphocyte escape viral variants: how important are they in viral evasion of immune clearance in vivo?

1998 • 60 citations

Inhibition of TCR triggering by a spectrum of altered peptide ligands suggests the mechanism for TCR antagonism

1998 • 51 citations

Characterizing the functionality of recombinant T-cell receptors in vitro: a pMHC tetramer based approach

2000 • 15 citations