Intracellular Amyloid-β1–42, but Not Extracellular Soluble Amyloid-β Peptides, Induces Neuronal Apoptosis

Neuropathological stageing of Alzheimer-related changes

1991 • 14,533 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

1999 • 3,692 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1993 • 1,422 citations

Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease

1997 • 1,395 citations

Amyloid, the presenilins and Alzheimer's disease

1997 • 1,370 citations

Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease

1994 • 1,213 citations

Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease

1999 • 1,115 citations

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1994 • 984 citations

Intraneuronal Aβ42 Accumulation in Human Brain

2000 • 955 citations

Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain

2001 • 876 citations

Distinct sites of intracellular production for Alzheimer's disease Aβ40/42 amyloid peptides

1997 • 698 citations

Widespread long-term gene transfer to mouse skeletal muscles and heart.

1992 • 586 citations

Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP

2001 • 581 citations

Immunohistochemical evidence for apoptosis in Alzheimerʼs disease

1994 • 569 citations

Serum‐free B27/neurobasal medium supports differentiated growth of neurons from the striatum, substantia nigra, septum, cerebral cortex, cerebellum, and dentate gyrus

1995 • 536 citations

Analysis of Heterogeneous βA4 Peptides in Human Cerebrospinal Fluid and Blood by a Newly Developed Sensitive Western Blot Assay

1996 • 477 citations

Alzheimer's Aβ(1–42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

1997 • 443 citations

Disruption of Axonal Transport and Neuronal Viability by Amyloid Precursor Protein Mutations in Drosophila

2001 • 424 citations

A second cytotoxic proteolytic peptide derived from amyloid β-protein precursor

2000 • 386 citations

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation

1999 • 369 citations

Intraneuronal Aβ accumulation precedes plaque formation in β-amyloid precursor protein and presenilin-1 double-transgenic mice

2001 • 337 citations

Detection of a Novel Intraneuronal Pool of Insoluble Amyloid β Protein that Accumulates with Time in Culture

1998 • 285 citations

Mechanisms of Neuronal Death in Alzheimer's Disease

1996 • 267 citations

REVIEWThe Gene Defects Responsible for Familial Alzheimer's Disease

1996 • 262 citations

Amyloid β interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease

2000 • 256 citations

Endoplasmic reticulum dysfunction – a common denominator for cell injury in acute and degenerative diseases of the brain?

2001 • 244 citations

Amyloid-β Peptides Are Cytotoxic to Oligodendrocytes

2001 • 213 citations

G Protein-Mediated Neuronal DNA Fragmentation Induced by Familial Alzheimer's Disease-Associated Mutants of APP

1996 • 213 citations

Characterization of apoptosis in cultured rat sympathetic neurons after nerve growth factor withdrawal

1994 • 184 citations

Adenovirus-mediated transfer of a recombinant human alpha 1-antitrypsin cDNA to human endothelial cells.

1992 • 180 citations

Ligand-dependent G Protein Coupling Function of Amyloid Transmembrane Precursor

1995 • 162 citations

γ-Secretase, Evidence for Multiple Proteolytic Activities and Influence of Membrane Positioning of Substrate on Generation of Amyloid β Peptides of Varying Length

1999 • 155 citations

Alzheimer’s disease: a dysfunction of the amyloid precursor protein11Published on the World Wide Web on 11 September 2000.

2000 • 137 citations

Activation of Neuronal Caspase-3 by Intracellular Accumulation of Wild-Type Alzheimer Amyloid Precursor Protein

1999 • 130 citations

Intracellular Aβ1-42 Aggregates Stimulate the Accumulation of Stable, Insoluble Amyloidogenic Fragments of the Amyloid Precursor Protein in Transfected Cells

1995 • 126 citations

PACAP Type I Receptor Activation Promotes Cerebellar Neuron Survival Through the cAMP/PKA Signaling Pathway

1997 • 110 citations

Intracellular Accumulation of Insoluble, Newly Synthesized Aβn-42 in Amyloid Precursor Protein-transfected Cells That Have Been Treated with Aβ1–42

1999 • 108 citations

Degeneration in vivo of rat hippocampal neurons by wild-type Alzheimer amyloid precursor protein overexpressed by adenovirus-mediated gene transfer.

1998 • 103 citations

DegenerationIn Vivoof Rat Hippocampal Neurons by Wild-Type Alzheimer Amyloid Precursor Protein Overexpressed by Adenovirus-Mediated Gene Transfer

1998 • 88 citations

Proteolytical processing of mutated human amyloid precursor protein in transgenic mice

1997 • 35 citations

The Amyloid Peptide and Its Precursor in Alzheimer's Disease

1995 • 34 citations

The Long Term Adenoviral Expression of the Human Amyloid Precursor Protein Shows Different Secretase Activities in Rat Cortical Neurons and Astrocytes

1998 • 32 citations

Missense Mutations Associated with Familial Alzheimer's Disease in Sweden Lead to the Production of the Amyloid Peptide without Internalization of Its Precursor

1996 • 22 citations