Comparison of genetically engineered herpes simplex viruses for the treatment of brain tumors in a scid mouse model of human malignant glioma.

Randomized Comparisons of Radiotherapy and Nitrosoureas for the Treatment of Malignant Glioma after Surgery

1980 • 1,625 citations

In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

1992 • 1,530 citations

Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant

1991 • 994 citations

Grading of astrocytomas: A simple and reproducible method

1988 • 902 citations

Characterization of Herpes Simplex Virus Strains Differing in their Effects on Social Behaviour of Infected Cells

1968 • 874 citations

Mapping of Herpes Simplex Virus-1 Neurovirulence to γ ₁ 34.5, a Gene Nonessential for Growth in Culture

1990 • 705 citations

Acyclovir-Resistant Herpes Simplex Virus Infections in Patients with the Acquired Immunodeficiency Syndrome

1989 • 470 citations

In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats.

1993 • 442 citations

The gamma 1(34.5) gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programed cell death in neuronal cells.

1992 • 396 citations

National survey of patterns of care for brain-tumor patients

1989 • 385 citations

High dose radiation therapy in the treatment of malignant gliomas: Final Report

1979 • 273 citations

Treatment of malignant gliomas using ganciclovir-hypersensitive, ribonucleotide reductase-deficient herpes simplex viral mutant.

1994 • 236 citations

Gene delivery to glioma cells in rat brain by grafting of a retrovirus packaging cell line

1990 • 195 citations

Replication, establishment of latency, and induced reactivation of herpes simplex virus gamma 1 34.5 deletion mutants in rodent models.

1993 • 187 citations

Reduction and Elimination of Encephalitis in an Experimental Glioma Therapy Model with Attenuated Herpes Simplex Mutants that Retain Susceptibility to Acyclovir

1993 • 177 citations

Gene therapy of maliganant brain tumors: A rat glioma line bearing the herpes simplex virus type 1‐thymidine kinase gene and wild type retrovirus kills other tumor cells

1992 • 170 citations

The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in rats

1994 • 158 citations

Correlates of survival and the Daumas-Duport grading system for astrocytomas

1991 • 157 citations

The terminal a sequence of the herpes simplex virus genome contains the promoter of a gene located in the repeat sequences of the L component

1986 • 149 citations

An experimental model of retrovirus gene therapy for malignant brain tumors

1993 • 143 citations

The herpes simplex virus 1 gene for ICP34.5, which maps in inverted repeats, is conserved in several limited-passage isolates but not in strain 17syn+

1990 • 129 citations

Toxicity studies of retroviral-mediated gene transfer for the treatment of brain tumors

1993 • 110 citations

In vivo transfer of the human interleukin-2 gene: negative tumoricidal results in experimental brain tumors

1994 • 87 citations

Tumorigenic cell culture lines from a spontaneous VM/Dk murine astrocytoma (SMA)

1980 • 82 citations

Identification by antibody to a synthetic peptide of a protein specified by a diploid gene located in the terminal repeats of the L component of herpes simplex virus genome

1986 • 81 citations

Differential response of human cells to deletions and stop codons in the gamma(1)34.5 gene of herpes simplex virus

1994 • 38 citations