Replication, establishment of latency, and induced reactivation of herpes simplex virus gamma 1 34.5 deletion mutants in rodent models.

The Complete DNA Sequence of the Long Unique Region in the Genome of Herpes Simplex Virus Type 1

1988 • 1,618 citations

Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant

1991 • 994 citations

Characterization of Herpes Simplex Virus Strains Differing in their Effects on Social Behaviour of Infected Cells

1968 • 874 citations

Mapping of Herpes Simplex Virus-1 Neurovirulence to γ ₁ 34.5, a Gene Nonessential for Growth in Culture

1990 • 705 citations

The gamma 1(34.5) gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programed cell death in neuronal cells.

1992 • 396 citations

Size, Composition, and Structure of the Deoxyribonucleic Acid of Herpes Simplex Virus Subtypes 1 and 2

1971 • 380 citations

Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate.

1989 • 360 citations

Inverted Repetitions in the Chromosome of Herpes Simplex Virus

1974 • 357 citations

Anatomy of herpes simplex virus DNA: evidence for four populations of molecules that differ in the relative orientations of their long and short components.

1975 • 337 citations

Anatomy of herpes simplex virus DNA. II. Size, composition, and arrangement of inverted terminal repetitions

1975 • 265 citations

In Vivo Behavior of Genetically Engineered Herpes Simplex Viruses R7017 and R7020: Construction and Evaluation in Rodents

1988 • 252 citations

Herpes simplex virus 1 mutant deleted in the alpha 22 gene: growth and gene expression in permissive and restrictive cells and establishment of latency in mice

1985 • 243 citations

A herpes simplex virus ribonucleotide reductase deletion mutant is defective for productive acute and reactivatable latent infections of mice and for replication in mouse cells

1989 • 225 citations

Structure and role of the herpes simplex virus DNA termini in inversion, circularization and generation of virion DNA

1982 • 225 citations

Genital Herpes in Guinea Pigs: Pathogenesis of the Primary Infection and Description of Recurrent Disease

1982 • 222 citations

Quantitative polymerase chain reaction analysis of herpes simplex virus DNA in ganglia of mice infected with replication-incompetent mutants

1990 • 182 citations

Reduction and Elimination of Encephalitis in an Experimental Glioma Therapy Model with Attenuated Herpes Simplex Mutants that Retain Susceptibility to Acyclovir

1993 • 177 citations

The terminal a sequence of the herpes simplex virus genome contains the promoter of a gene located in the repeat sequences of the L component

1986 • 149 citations

Ocular disease pattern induced by herpes simplex virus is genetically determined by a specific region of viral DNA.

1982 • 131 citations

The herpes simplex virus 1 gene for ICP34.5, which maps in inverted repeats, is conserved in several limited-passage isolates but not in strain 17syn+

1990 • 129 citations

Identification by antibody to a synthetic peptide of a protein specified by a diploid gene located in the terminal repeats of the L component of herpes simplex virus genome

1986 • 81 citations

Recurrent Genital Herpes Simplex Virus Infection in Guinea Pigs

1985 • 65 citations

Herpes simplex virus neurovirulence and productive infection of neural cells is associated with a function which maps between 0.82 and 0.832 map units on the hsv genome

1989 • 58 citations

Efficacy of Recombinant Glycoprotein D Subunit Vaccines on the Development of Primary, Recurrent, and Latent Genital Infections with Herpes Simplex Virus Type 2 in Guinea Pigs

1988 • 57 citations

The Herpes Simplex Virus Type 2 (HG52) Variant JH2604 Has a 1488 bp Deletion which Eliminates Neurovirulence in Mice

1989 • 56 citations

Genetic and biological analyses of a herpes simplex virus intertypic recombinant reduced specifically for neurovirulence

1987 • 49 citations

A Variant of Herpes Simplex Virus Type 2 Strain HG52 with a 1.5 kb Deletion in RL between 0 to 0.02 and 0.81 to 0.83 Map Units Is Non-neurovirulent for Mice

1989 • 45 citations

Reduction and Elimination of Encephalitis in an Experimental Glioma Therapy Model with Attenuated Herpes Simplex Mutants that Retain Susceptibility to Acyclovir

1993 • 42 citations

The JH2604 deletion variant of herpes simplex virus type 2 (HG52) fails to produce necrotizing encephalitis following intracranial inoculation of mice

1990 • 21 citations

Acyclovir treatment of disseminated herpes simplex virus type 2 infection in weanling mice: Alteration of mortality and pathogenesis

1986 • 21 citations

Acyclovir treatment of experimental genital herpes simplex virus infections. I. Topical therapy of type 2 and type 1 infections of mice

1983 • 8 citations