Transmembrane signaling by the B subunit of cholera toxin: increased cytoplasmic free calcium in rat lymphocytes.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.

1982 • 2,255 citations

Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ

1979 • 2,166 citations

Cytoplasmic pH and free Mg2+ in lymphocytes.

1982 • 1,047 citations

T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes

1982 • 1,026 citations

Mechanism of cholera toxin action: Covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system

1978 • 902 citations

Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis?

1984 • 734 citations

A common sequence of calcium and pH signals in the mitogenic stimulation of eukaryotic cells

1985 • 456 citations

Role of membrane gangliosides in the binding and action of bacterial toxins

1982 • 396 citations

Interleukin-2 stimulates association of protein kinase C with plasma membrane

1985 • 384 citations

Lymphocyte membrane potential assessed with fluorescent probes

1980 • 336 citations

The role of calcium ions in initiating transformation of lymphocytes

1974 • 271 citations

Characterization of the activation of Na+/H+ exchange in lymphocytes by phorbol esters: change in cytoplasmic pH dependence of the antiport.

1985 • 254 citations

Mitogens increase phosphorylation of phosphoinositides in thymocytes

1984 • 223 citations

Protein kinase C and calcium ion in mitogenic response of macrophage-depleted human peripheral lymphocytes.

1985 • 220 citations

The role of calcium in lymphocyte proliferation. (An interpretive review)

1983 • 151 citations

Single-channel and whole-cell recordings of mitogen-regulated inward currents in human cloned helper T lymphocytes

1986 • 151 citations

Ligand-induced redistribution of lymphocyte membrane ganglioside GM1

1975 • 150 citations

Regulation of lymphocyte responses by human gangliosides. I. Characteristics of inhibitory effects and the induction of impaired activation.

1980 • 128 citations

Gangliosides as bimodal regulators of cell growth.

1987 • 128 citations

Role of membrane potential in the regulation of lectin‐induced calcium uptake

1984 • 121 citations

Calcium‐dependent activation of lymphocytes by ionophore, A23187, and a phorbol ester tumor promoter

1983 • 120 citations

Direct Evidence That Endogenous G _M1 Ganglioside Can Mediate Thymocyte Proliferation

1985 • 110 citations

The suppressive effect of gangliosides upon IL 2-dependent proliferation as a function of inhibition of IL 2-receptor association.

1986 • 105 citations

Direct visualization of redistribution and capping of fluorescent gangliosides on lymphocytes.

1984 • 94 citations

Mitogens trigger a calcium-independent signal for proliferation in phorbol-ester-treated lymphocytes

1985 • 88 citations

Mitogen-induced changes in Ca2+ permeability are not mediated by voltage-gated K+ channels.

1986 • 88 citations

Volume restoration in osmotically swollen lymphocytes does not involve changes in free Ca2+ concentration

1983 • 86 citations

Inhibition of the lectin-induced mitogenic response of thymocytes by glycolipids.

1979 • 85 citations

Translocation of phospholipid/Ca2+-dependent protein kinase in B-lymphocytes activated by phorbol ester or cross-linking of membrane immunoglobulin

1986 • 85 citations

Protein phosphorylation during activation of Na+/H+ exchange by phorbol esters and by osmotic shrinking. Possible relation to cell pH and volume regulation.

1986 • 73 citations

Intracellular pH of stimulated thymocytes measured with a new fluorescent indicator.

1983 • 72 citations

Bilayers containing gangliosides develop channels when exposed to cholera toxin

1978 • 67 citations

Detergent extraction of cholera toxin and gangliosides from cultured cells and isolated membranes

1982 • 57 citations

Capping of cholera toxin-ganglioside GM1 complexes on mouse lymphocytes is accompanied by co-capping of alpha-actinin.

1983 • 54 citations

Metabolic Carbohydrate‐Labelling of Glycolipids from Mouse Splenocytes

1979 • 50 citations

Effect of the A and B protomers of choleragen on release of trapped glucose from liposomes containing or lacking ganglioside GM1.

1977 • 50 citations

K channels are expressed early in human T-cell development.

1986 • 45 citations

Activation of the Na+/H+ antiport is not required for lectin-induced proliferation of human T lymphocytes.

1986 • 41 citations

Involvement of gangliosides in lymphocyte stimulation.

1979 • 38 citations

Membrane sialoglycolipids emerging as possible signal transducers for lymphocyte stimulation.

1981 • 36 citations

Calcium-activated potassium channels in lymphocytes

1983 • 29 citations