Aspects of Innate Immunity and Parkinson’s Disease

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

2000 • 3,559 citations

Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA

2004 • 3,325 citations

Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1

2004 • 3,278 citations

AGEING AND PARKINSON'S DISEASE: SUBSTANTIA NIGRA REGIONAL SELECTIVITY

1991 • 3,275 citations

Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

2005 • 3,059 citations

Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

1988 • 2,754 citations

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

2010 • 2,658 citations

Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

2002 • 1,877 citations

Innate immune recognition of viral infection

2006 • 1,790 citations

MITOCHONDRIAL COMPLEX I DEFICIENCY IN PARKINSON'S DISEASE

1989 • 1,717 citations

Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System

2000 • 1,628 citations

Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen

2003 • 1,481 citations

The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

1995 • 1,266 citations

Mitochondria in innate immune responses

2011 • 1,186 citations

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

2005 • 1,172 citations

Ubiquitin signalling in the NF-κB pathway

2005 • 1,137 citations

Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease

2008 • 1,078 citations

Sirtuin 2 Inhibitors Rescue α-Synuclein-Mediated Toxicity in Models of Parkinson's Disease

2007 • 1,022 citations

Parkin functions as an E2-dependent ubiquitin– protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

2000 • 975 citations

α-Synuclein Cooperates with CSPα in Preventing Neurodegeneration

2005 • 930 citations

NF-κB signaling pathways in mammalian and insect innate immunity

2001 • 892 citations

Atypical ubiquitin chains: new molecular signals

2008 • 797 citations

Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’

2011 • 771 citations

The UCH-L1 Gene Encodes Two Opposing Enzymatic Activities that Affect α-Synuclein Degradation and Parkinson's Disease Susceptibility

2002 • 768 citations

Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease

2010 • 751 citations

Recognition and Signaling by Toll-Like Receptors

2006 • 703 citations

Innate immunity: the missing link in neuroprotection and neurodegeneration?

2002 • 695 citations

CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation

1998 • 667 citations

Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-κB activation

2006 • 587 citations

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

2005 • 554 citations

What Genetics Tells us About the Causes and Mechanisms of Parkinson's Disease

2011 • 546 citations

The influence of systemic inflammation on inflammation in the brain: implications for chronic neurodegenerative disease

2004 • 534 citations

Nigrostriatal Dopaminergic Deficits and Hypokinesia Caused by Inactivation of the Familial Parkinsonism-Linked Gene DJ-1

2005 • 518 citations

Failure of the ubiquitin–proteasome system in Parkinson's disease

2001 • 508 citations

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

2001 • 490 citations

Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death

2001 • 482 citations

Antiviral innate immunity pathways

2006 • 458 citations

Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis

2005 • 418 citations

Glia: Initiators and progressors of pathology in Parkinson's disease

2011 • 410 citations

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death

2003 • 388 citations

LRRK2 Is Involved in the IFN-γ Response and Host Response to Pathogens

2010 • 374 citations

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

1999 • 372 citations

Proteasomal Inhibition by α-Synuclein Filaments and Oligomers

2004 • 368 citations

A possible role for humoral immunity in the pathogenesis of Parkinson's disease

2005 • 332 citations

PINK1 protein in normal human brain and Parkinson's disease

2006 • 328 citations

An inflammatory review of Parkinson’s disease

2002 • 318 citations

The absence of reactive astrocytosis is indicative of a unique inflammatory process in Parkinson's disease

1999 • 318 citations

The Co-chaperone Carboxyl Terminus of Hsp70-interacting Protein (CHIP) Mediates α-Synuclein Degradation Decisions between Proteasomal and Lysosomal Pathways

2005 • 317 citations

Activation of microglia by human neuromelanin is NF‐κB‐dependent and involves p38 mitogen‐activated protein kinase: implications for Parkinson's disease

2003 • 303 citations

Parkinsonism Induced By 1-Methyl-4-Phenyl-1, 2, 3, 6-Tetrahydropyridine (MPTP): Implications for Treatment and the Pathogenesis of Parkinson’s Disease

1984 • 277 citations

Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1

2003 • 275 citations

A Cytoplasmic ATM-TRAF6-cIAP1 Module Links Nuclear DNA Damage Signaling to Ubiquitin-Mediated NF-κB Activation

2010 • 272 citations

Neural Activity Controls the Synaptic Accumulation of α-Synuclein

2005 • 266 citations

The Genetics of Crohn's Disease

2009 • 252 citations

Toll-Like Receptor 4 Promotes α-Synuclein Clearance and Survival of Nigral Dopaminergic Neurons

2011 • 247 citations

Lysines 128 and 132 Enable Lipopolysaccharide Binding to MD-2, Leading to Toll-like Receptor-4 Aggregation and Signal Transduction

2003 • 238 citations

In utero bacterial endotoxin exposure causes loss of tyrosine hydroxylase neurons in the postnatal rat midbrain

2002 • 238 citations

Role of ICAM-1 in persisting inflammation in Parkinson disease and MPTP monkeys

2005 • 230 citations

The lipopolysaccharide Parkinson’s disease animal model: mechanistic studies and drug discovery

2008 • 218 citations

The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI

2003 • 217 citations

Nonsteroidal anti-inflammatory drugs may protect against Parkinson disease

2007 • 209 citations

Emerging Role of ISG15 in Antiviral Immunity

2010 • 208 citations

Endogenous α-Synuclein Is Induced by Valproic Acid through Histone Deacetylase Inhibition and Participates in Neuroprotection against Glutamate-Induced Excitotoxicity

2006 • 190 citations

Ulcerative colitis exacerbates lipopolysaccharide-induced damage to the nigral dopaminergic system: potential risk factor in Parkinson`s disease

2010 • 179 citations

Increased Mitochondrial Calcium Sensitivity and Abnormal Expression of Innate Immunity Genes Precede Dopaminergic Defects in Pink1-Deficient Mice

2011 • 174 citations

Prenatal exposure to the bacteriotoxin lipopolysaccharide leads to long term losses of dopamine neurons in offspring a potential new model of parkinson s disease

2003 • 157 citations

The role of poly(ADP-ribose) polymerase-1 in CNS disease

2006 • 145 citations

NF-κB activation by double-strand breaks

2006 • 132 citations

Parkin is associated with cellular vesicles

2001 • 132 citations

The Gut Immune Barrier and the Blood-Brain Barrier: Are They So Different?

2009 • 130 citations

Innate and Adaptive Immunity for the Pathobiology of Parkinson's Disease

2009 • 128 citations

α-Synuclein and Parkin Contribute to the Assembly of Ubiquitin Lysine 63-linked Multiubiquitin Chains

2005 • 126 citations

Regulation of proteasome complexes by γ-interferon and phosphorylation

2001 • 125 citations

Starring roles for astroglia in barrier pathologies of gut and brain

2007 • 123 citations

Meta-analysis of published studies identified eight additional common susceptibility loci for Crohnʼs disease and ulcerative colitis

2011 • 106 citations

Innate Immune recognition of viral infection

2006 • 105 citations

Early involvement of the cerebral cortex in Parkinson's disease: Convergence of multiple metabolic defects

2009 • 101 citations

Modulation of microglial pro-inflammatory and neurotoxic activity for the treatment of Parkinson’s disease

2006 • 100 citations

Selective loss of dopaminergic nigro-striatal neurons in brains of Atm-deficient mice

1998 • 100 citations

Leprosy susceptibility: genetic variations regulate innate and adaptive immunity, and disease outcome

2011 • 97 citations

The Toll-Like Receptor-3 Agonist Polyinosinic:Polycytidylic Acid Triggers Nigrostriatal Dopaminergic Degeneration

2010 • 96 citations

Circulating interleukin-10 and interleukin-12 in Parkinson’s disease

2009 • 95 citations

Regulation of α-Synuclein Expression by Poly (ADP Ribose) Polymerase-1 (PARP-1) Binding to the NACP-Rep1 Polymorphic Site Upstream of the SNCA Gene

2005 • 94 citations

Double‐stranded RNA signals antiviral and inflammatory programs and dysfunctional glutamate transport in TLR3‐expressing astrocytes

2005 • 88 citations

Astrocytic but not neuronal increased expression and redistribution of parkin during unfolded protein stress

2002 • 88 citations

Genetic mouse models for Parkinson's disease display severe pathology in glial cell mitochondria

2011 • 85 citations

Regulation of MyD88 Aggregation and the MyD88-dependent Signaling Pathway by Sequestosome 1 and Histone Deacetylase 6

2010 • 82 citations

TRAF5 Is a Downstream Target of MAVS in Antiviral Innate Immune Signaling

2010 • 81 citations

The RNA binding protein Sam68 is acetylated in tumor cell lines, and its acetylation correlates with enhanced RNA binding activity

2004 • 79 citations

Systemic administration of neuregulin‐1β₁ protects dopaminergic neurons in a mouse model of Parkinson’s disease

2011 • 73 citations

CARD15 variants in patients with sporadic Parkinson's disease

2006 • 72 citations

Studies on genomic DNA topology and stability in brain regions of Parkinson’s disease

2006 • 69 citations

Evidence for More than One Parkinson's Disease-Associated Variant within the HLA Region

2011 • 66 citations

Signals from the Nucleus: Activation of NF-κB by Cytosolic ATM in the DNA Damage Response

2011 • 56 citations

A Novel Role for ATM in Regulating Proteasome-Mediated Protein Degradation through Suppression of the ISG15 Conjugation Pathway

2011 • 51 citations

LRRK2 and parkin immunoreactivity in multiple system atrophy inclusions

2008 • 45 citations

LRRK2 is expressed in B-2 but not in B-1 B cells, and downregulated by cellular activation

2010 • 41 citations

Interferon-γ-inducible subunits are incorporated in human brain 20S proteasome

2003 • 41 citations

Mitochondria in Parkinson Disease

2006 • 33 citations

Parkinson’s disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans

2010 • 31 citations

Alpha-synuclein: between synaptic function and dysfunction.

2003 • 31 citations

Postencephalitic parkinsonism and basal ganglia necrosis due to Epstein-Barr virus infection

2011 • 30 citations

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death

2003 • 27 citations

Microarray expression analysis of gad mice implicates involvement of Parkinson's disease associated UCH-L1 in multiple metabolic pathways

2004 • 25 citations

Genome-wide expression profiling implicates a MAST3-regulated gene set in colonic mucosal inflammation of ulcerative colitis patients

2011 • 25 citations

Clinical correlates of similar pathologies in parkinsonian syndromes

2011 • 19 citations

'Protein Modifications: Beyond the Usual Suspects' Review Series

2008 • 19 citations

VISA—A pass to innate immunity

2006 • 18 citations

Alpha-synuclein inhibits poly (ADP-ribose) polymerase-1 (PARP-1) activity via NO-dependent pathway.

2009 • 15 citations

CD3 in Lewy pathology: does the abnormal recall of neurodevelopmental processes underlie Parkinson’s disease

2010 • 13 citations

Nicht-steroidale Analgetika haben keinen protektiven Effekt gegen M. Parkinson

2011 • 3 citations

Microarray expression analysis of gad mice implicates involvement of Parkinson's disease associated UCH-L1 in multiple metabolic pathways

2004 • 2 citations