Genetic mouse models for Parkinson's disease display severe pathology in glial cell mitochondria
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References (54)
Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1
2004 • 3,278 citations
A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function
2008 • 2,939 citations
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
2010 • 2,550 citations
Mitochondrial Complex I Deficiency in Parkinson's Disease
1990 • 2,147 citations
The Fine Structure of the Nervous System.
1970 • 1,971 citations
MITOCHONDRIAL COMPLEX I DEFICIENCY IN PARKINSON'S DISEASE
1989 • 1,717 citations
Aggregated α‐synuclein activates microglia: a process leading to disease progression in Parkinson's disease
2005 • 1,122 citations
Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice
2004 • 959 citations
The PINK1/Parkin pathway regulates mitochondrial morphology
2008 • 845 citations
Expanding insights of mitochondrial dysfunction in Parkinson's disease
2006 • 841 citations
Mitochondria in the aetiology and pathogenesis of Parkinson's disease
2008 • 826 citations
Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis
2008 • 745 citations
Deficiencies in Complex I subunits of the respiratory chain in Parkinson's disease
1989 • 735 citations
Parkinson's Disease Brain Mitochondrial Complex I Has Oxidatively Damaged Subunits and Is Functionally Impaired and Misassembled
2006 • 703 citations
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
2008 • 673 citations
Parkinson's Disease α-Synuclein Transgenic Mice Develop Neuronal Mitochondrial Degeneration and Cell Death
2006 • 648 citations
The mitochondrial permeability transition initiates autophagy in rat hepatocytes
2001 • 596 citations
α-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease
2002 • 511 citations
Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease
2007 • 429 citations
Mitochondria: The Hub of Cellular Ca2+Signaling
2008 • 381 citations
Enhanced substantia nigra mitochondrial pathology in human α-synuclein transgenic mice after treatment with MPTP111-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
2003 • 291 citations
Autophagy, organelles and ageing
2007 • 283 citations
Behavioral and Neurochemical Effects of Wild-Type and Mutated Human α-Synuclein in Transgenic Mice
2002 • 280 citations
Neural Activity Controls the Synaptic Accumulation of α-Synuclein
2005 • 266 citations
Parkin enhances mitochondrial biogenesis in proliferating cells
2006 • 261 citations
Proteolytic Cleavage of Extracellular Secreted α-Synuclein via Matrix Metalloproteinases
2005 • 224 citations
GDNF and GFRα1 Promote Differentiation and Tangential Migration of Cortical GABAergic Neurons
2005 • 188 citations
Mono- and double-mutant mouse models of Parkinson's disease display severe mitochondrial damage
2007 • 174 citations
Mitochondrial associated metabolic proteins are selectively oxidized in A30P α-synuclein transgenic mice—a model of familial Parkinson's disease
2005 • 167 citations
Proteomic analysis of parkin knockout mice: alterations in energy metabolism, protein handling and synaptic function
2005 • 160 citations
Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson’s disease by disturbing calcium flux
2009 • 149 citations
Origins and Effects of Extracellular α-synuclein: Implications in Parkinson’s Disease
2007 • 145 citations
Demonstration of α-Synuclein Immunoreactivity in Neuronal and Glial Cytoplasm in Normal Human Brain Tissue Using Proteinase K and Formic Acid Pretreatment
2002 • 138 citations
α-Synuclein Expression Modulates Microglial Activation Phenotype
2006 • 136 citations
Review: Familial Parkinson's disease – genetics, clinical phenotype and neuropathology in relation to the common sporadic form of the disease
2008 • 132 citations
Glial degeneration and reactive gliosis in alpha-synucleinopathies: the emerging concept of primary gliodegeneration
2006 • 123 citations
Glial Dysfunction in Parkin Null Mice: Effects of Aging
2008 • 116 citations
Non‐motor behavioural impairments in parkin‐deficient mice
2007 • 112 citations
Plasma membrane ion permeability induced by mutant α‐synuclein contributes to the degeneration of neural cells
2006 • 107 citations
DJ-1 knock-down in astrocytes impairs astrocyte-mediated neuroprotection against rotenone
2008 • 105 citations
Parkin expression in the adult mouse brain
2000 • 92 citations
Genes associated with Parkinson syndrome
2008 • 90 citations
Apoptotic Cell Death of Cultured Cerebral Cortical Neurons Induced by Withdrawal of Astroglial Trophic Support
1998 • 67 citations
An early cytoplasmic change before Lewy body maturation: an ultrastructural study of the substantia nigra from an autopsy case of juvenile parkinsonism
1993 • 66 citations
The Role of Astroglia on the Survival of Dopamine Neurons
2002 • 64 citations
Modulation of cell calcium signals by mitochondria.
1998 • 62 citations
LRRK2 and parkin immunoreactivity in multiple system atrophy inclusions
2008 • 45 citations
Untitled
1998 • 45 citations
Additive effect of glial cell line-derived neurotrophic factor and neurotrophin-4/5 on rat fetal nigral explant cultures
2001 • 40 citations
Influence of Different Promoters on the Expression Pattern of Mutated Human α-Synuclein in Transgenic Mice
2004 • 36 citations
Ultrastructure of PkC(II/III)-immunopositive structures in rat primary visual cortex
1990 • 33 citations
Ultrastructure of the nervous system.
1975 • 19 citations
Parkin expression in the adult mouse brain
2000 • 9 citations
Phagocytosis of degenerating myelin in transected feline optic nerve: an immunohistochemical study
2004 • 2 citations