Egg Membranes during Fertilization

The synaptic vesicle cycle: a cascade of protein–protein interactions

1995 • 2,004 citations

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1992 • 1,046 citations

Intracytoplasmic Sperm Injection in the Mouse1

1995 • 1,009 citations

Repetitive calcium transients and the role of calcium in exocytosis and cell cycle activation in the mouse egg

1992 • 693 citations

A potential fusion peptide and an integrin ligand domain in a protein active in sperm–egg fusion

1992 • 680 citations

Oocyte Maturation

1979 • 662 citations

Ca ²⁺ -Induced Ca ²⁺ Release in Sea Urchin Egg Homogenates: Modulation by Cyclic ADP-Ribose

1991 • 628 citations

A free calcium wave traverses the activating egg of the medaka, Oryzias latipes.

1978 • 546 citations

The T Cell Receptor as a Multicomponent Signalling Machine: CD4/CD8 Coreceptors and CD45 in T Cell Activation

1992 • 539 citations

Intracellular calcium release at fertilization in the sea urchin egg

1977 • 523 citations

Essential Role of the Inositol 1,4,5-Trisphosphate Receptor/Ca2+ Release Channel in Ca2+ Waves and Ca2+ Oscillations at Fertilization of Mammalian Eggs

1993 • 521 citations

Biochemistry And Biophysics Of Excitation-Contraction Coupling

1989 • 494 citations

Block of Ca ²⁺ Wave and Ca ²⁺ Oscillation by Antibody to the Inositol 1,4,5-Trisphosphate Receptor in Fertilized Hamster Eggs

1992 • 493 citations

Mouse egg integrin α6β1functions as a sperm receptor

1995 • 472 citations

A cytosolic sperm factor stimulates repetitive calcium increases and mimics fertilization in hamster eggs

1990 • 456 citations

Fast block to polyspermy in sea urchin eggs is electrically mediated

1976 • 456 citations

Biology of Fertilization

1985 • 452 citations

ADAM, a Widely Distributed and Developmentally Regulated Gene Family Encoding Membrane Proteins with A̱Ḏisintegrin A̱nd M̱etalloprotease Domain

1995 • 406 citations

The ryanodine receptor/Ca2+ release channel

1993 • 404 citations

Mouse oocytes injected with testicular spermatozoa or round spermatids can develop into normal offspring

1995 • 394 citations

Identification and purification of a sperm surface protein with a potential role in sperm-egg membrane fusion.

1987 • 368 citations

Free calcium increases explosively in activating medaka eggs.

1977 • 367 citations

The isolation of intact cortical granules from sea urchin eggs: Calcium ions trigger granule discharge

1975 • 350 citations

cGMP mobilizes intracellular Ca2+ in sea urchin eggs by stimulating cyclic ADP-ribose synthesis

1993 • 337 citations

Lighting the fuse at fertilization

1993 • 328 citations

Inositol 1,4,5-trisphosphate microinjection activates sea urchin eggs

1984 • 316 citations

Redundant Mechanisms of Calcium-Induced Calcium Release Underlying Calcium Waves During Fertilization of Sea Urchin Eggs

1993 • 313 citations

Direct measurement of intracellular pH during metabolic derepression of the sea urchin egg

1978 • 300 citations

Calcium Mobilization by Dual Receptors During Fertilization of Sea Urchin Eggs

1993 • 296 citations

Electrical Properties of Egg Cell Membranes

1979 • 277 citations

Inositol 1,4,5-trisphosphate-induced calcium release and guanine nucleotide-binding protein-mediated periodic calcium rises in golden hamster eggs

1988 • 256 citations

Activation of frog (Xenopus laevis) eggs by inositol trisphosphate. I. Characterization of Ca2+ release from intracellular stores.

1985 • 255 citations

The part played by inositol trisphosphate and calcium in the propagation of the fertilization wave in sea urchin eggs.

1986 • 253 citations

The path of calcium in cytosolic calcium oscillations: a unifying hypothesis.

1991 • 251 citations

Molecular Events Mediating Sperm Activation

1993 • 242 citations

Identification of a binding site in the disintegrin domain of fertilin required for sperm-egg fusion.

1994 • 241 citations

THE FINE STRUCTURE OF PRONUCLEAR DEVELOPMENT AND FUSION IN THE SEA URCHIN, ARBACIA PUNCTULATA

1968 • 238 citations

Organization of the sea urchin egg endoplasmic reticulum and its reorganization at fertilization.

1991 • 225 citations

Transmembrane signalling by integrins

1992 • 219 citations

Regulation of Intracellular Calcium in the Mouse Egg: Calcium Release in Response to Sperm or Inositol Trisphosphate is Enhanced after Meiotic Maturation1

1994 • 213 citations

Injection of a soluble sperm fraction into sea-urchin eggs triggers the cortical reaction

1985 • 211 citations

Fertilization increases the polyphosphoinositide content of sea urchin eggs

1984 • 209 citations

Bioelectric Responses of the Echinoderm Egg to Fertilization

1971 • 199 citations

Activation of mammalian oocytes by a factor obtained from rabbit sperm

1990 • 198 citations

Membrane fusion during secretion: cortical granule exocytosis in sex urchin eggs as studied by quick-freezing and freeze-fracture.

1979 • 196 citations

Comparison of Ca2+ mobilizing activities of cyclic ADP-ribose and inositol trisphosphate.

1990 • 188 citations

Quantitative studies of changes in cortical granule number and distribution in the mouse oocyte during meiotic maturation

1988 • 188 citations

A fast block to polyspermy in frogs mediated by changes in the membrane potential

1980 • 182 citations

The Sperm-Induced Ca2+ Wave Following Fertilization of the Xenopus Egg Requires the Production of Ins(1,4,5)P3

1993 • 177 citations

Reorganization of the Endoplasmic Reticulum during Meiotic Maturation of the Mouse Oocyte

1995 • 175 citations

Development of Inositol Trisphosphate-Induced Calcium Release Mechanism during Maturation of Hamster Oocytes

1993 • 167 citations

Different triggers for calcium oscillations in mouse eggs involve a ryanodine-sensitive calcium store

1992 • 166 citations

The Role of Calcium Explosions, Waves, and Pulses in Activating Eggs

1985 • 164 citations

Sea Urchin Egg Receptor for Sperm: Sequence Similarity of Binding Domain and hsp70

1993 • 164 citations

Calcium-dependent events at fertilization of the frog egg: Injection of a calcium buffer blocks ion channel opening, exocytosis, and formation of pronuclei

1988 • 163 citations

Calmodulin confers calcium sensitivity on secretory exocytosis

1982 • 155 citations

The role of membranes in the organization of the mitotic apparatus

1975 • 154 citations

Translational control of InsP3-induced chromatin condensation during the early cell cycles of sea urchin embryos

1988 • 152 citations

Polyspermy-Preventing Mechanisms

1985 • 146 citations

Two phases of inositol polyphosphate and diacylglycerol production at fertilisation

1986 • 142 citations

Detyrosination of alpha tubulin does not stabilize microtubules in vivo [published erratum appears in J Cell Biol 1990 Sep;111(3):1325-6]

1990 • 141 citations

Development of calcium release mechanisms during starfish oocyte maturation

1990 • 140 citations

Molecular Mechanisms of Sperm-Egg Membrane Binding and Fusion in Mammals

1993 • 139 citations

Surface area change at fertilization: Resorption of the mosaic membrane

1979 • 134 citations

Direct measurement of intracellular pH changes in Xenopus eggs at fertilization and cleavage.

1981 • 130 citations

Fertilization Events Induced by Neurotransmitters After Injection of mRNA in Xenopus Eggs

1988 • 129 citations

Expression of β1 integrin complexes on the surface of unfertilized mouse oocyte

1993 • 127 citations

Mechanism of Ca2+ inhibition of inositol 1,4,5-trisphosphate (InsP3) binding to the cerebellar InsP3 receptor.

1992 • 125 citations

Electrically mediated fast polyspermy block in eggs of the marine worm, Urechis caupo.

1979 • 125 citations

Source and sinks for the calcium released during fertilization of single sea urchin eggs.

1985 • 124 citations

Developmental Changes in the Distribution of the Endoplasmic Reticulum and Inositol 1,4,5-Trisphosphate Receptors and the Spatial Pattern of Ca2+ Release during Maturation of Hamster Oocytes

1995 • 124 citations

Site of sperm entry and a cortical contraction associated with egg activation in the frog Rana pipens

1975 • 122 citations

Prevention of the cortical reaction in fertilized sea urchin eggs by injection of calcium-chelating ligands

1978 • 122 citations

The onset of activation responsiveness during maturation coincides with the formation of the cortical endoplasmic reticulum in oocytes of Xenopus laevis

1984 • 119 citations

Fast polyspermy block and activation potential

1979 • 118 citations

Cortical localization of a calcium release channel in sea urchin eggs.

1992 • 118 citations

Absence of an electrical polyspermy block in the mouse

1983 • 116 citations

Regulation of the Polyspermy Block in the Mouse Egg: Maturation-Dependent Differences in Cortical Granule Exocytosis and Zona Pellucida Modifications Induced by Inositol 1,4,5-Trisphosphate and an Activator of Protein Kinase C1

1993 • 107 citations

Intracellular pH and the sodium requirement at fertilisation

1979 • 107 citations

Initiation of the activation potential by an increase in intracellular calcium in eggs of the frog, Rana pipiens

1981 • 107 citations

Activation of sea urchin eggs by microinjection of calcium buffers

1981 • 106 citations

Membrane Fusion in Relation to Sperm-Egg Association**Part of the work reported here was supported by National Institutes of Health research grants GM-04948 and HD-00007.

1967 • 106 citations

Sources of Calcium in Sea Urchin Eggs during the Fertilization Response

1993 • 105 citations

Fusion of membranes during fertilization. Increases of the sea urchin egg's membrane capacitance and membrane conductance at the site of contact with the sperm.

1992 • 103 citations

Rapid visual detection of sperm-egg fusion using the DNA-specific fluorochrome Hoechst 33342

1986 • 101 citations

Periodic increase of cytoplasmic free calcium in fertilized hamster eggs measured with calcium‐sensitive electrodes.

1986 • 101 citations

MEMBRANE POTENTIAL AND RESISTANCE OF THE STARFISH EGG BEFORE AND AFTER FERTILIZATION

1956 • 100 citations

A calsequestrin-like protein in the endoplasmic reticulum of the sea urchin: localization and dynamics in the egg and first cell cycle embryo.

1989 • 100 citations

Electrical Regulation of Sperm-EGG Fusion

1986 • 98 citations

Evidence for Both Tyrosine Kinase and G-Protein-Coupled Pathways Leading to Starfish Egg Activation

1994 • 97 citations

The activation wave of calcium in the ascidian egg and its role in ooplasmic segregation.

1990 • 97 citations

The modifications of cortical endoplasmic reticulum during in vitro maturation of Xenopus laevis oocytes and its involvement in cortical granule exocytosis

1984 • 97 citations

Inositol 1,4,5-trisphosphate mass changes from fertilization through first cleavage in Xenopus laevis.

1993 • 96 citations

1 How do Sperm Activate Eggs?

1991 • 95 citations

Ca-mediated activation of a K current at fertilization of golden hamster eggs.

1982 • 95 citations

Correlative ultrastructural and electrophysiological studies of sperm-egg interactions of the sea urchin, Lytechinus variegatus

1986 • 95 citations

Demonstration of calcium uptake and release by sea urchin egg cortical endoplasmic reticulum.

1991 • 92 citations

Calcium-dependent exocytosis in an in vitro secretory granule plasma membrane preparation from sea urchin eggs and the effects of some inhibitors of cytoskeletal function

1983 • 91 citations

Ionic mechanism of the fertilization potential of the marine worm, Urechis caupo (Echiura).

1979 • 91 citations

A rapid change in phosphorylation on tyrosine accompanies fertilization of sea urchin eggs

1991 • 90 citations

Membrane Interaction and Conformational Properties of the Putative Fusion Peptide of PH-30, a Protein Active in Sperm-Egg Fusion

1994 • 89 citations

The time course of cortical vesicle fusion in sea urchin eggs observed as membrane capacitance changes

1978 • 89 citations

Complete Mouse Egg Activation in the Absence of Sperm by Stimulation of an Exogenous G Protein-Coupled Receptor

1993 • 87 citations

Sperm-Egg Fusion

1986 • 86 citations

The wave of activation current in the Xenopus egg

1985 • 83 citations

Structural changes in the endoplasmic reticulum of starfish oocytes during meiotic maturation and fertilization

1994 • 83 citations

Role of G proteins in mouse egg activation: Stimulatory effects of acetylcholine on the ZP2 to ZP2f conversion and pronuclear formation in eggs expressing a functional m1 muscarinic receptor

1992 • 81 citations

Voltage clamp studies of fertilization in sea urchin eggs

1984 • 80 citations

Sea urchin egg cortical granule exocytosis is followed by a burst of membrane retrieval via uptake into coated vesicles

1983 • 79 citations

Reconstitution of T Cell Receptor ζ-Mediated Calcium Mobilization in Nonlymphoid Cells

1993 • 79 citations

Ionic Signaling in the Sea Urchin Egg at Fertilization

1985 • 79 citations

Evidence for the involvement of a pertussis toxin-insensitive G-protein in egg activation of the frog, Xenopus laevis

1991 • 78 citations

Guanosine 5'-thiotriphosphate may stimulate phosphoinositide messenger production in sea urchin eggs by a different route than the fertilizing sperm.

1991 • 77 citations

Ooplasmic transfusion: prophase germinal vesicle oocytes made developmentally competent by microinjection of metaphase II egg cytoplasm

1990 • 77 citations

Interaction of the sperm adhesive protein, bindin, with phospholipid vesicles. II. Bindin induces the fusion of mixed-phase vesicles that contain phosphatidylcholine and phosphatidylserine in vitro.

1985 • 74 citations

Pertussis toxin inhibits 1-methyladenine-induced maturation in starfish oocytes

1989 • 74 citations

Internal calcium release and activation of sea urchin eggs by cGMP are independent of the phosphoinositide signaling pathway.

1992 • 73 citations

Studies of the voltage-dependent polyspermy block using cross-species fertilization of amphibians

1983 • 73 citations

Src-related protein tyrosine kinases and T-cell receptor signalling

1992 • 73 citations

Wave of free calcium at fertilization in the sea urchin egg visualized with fura‐2

1988 • 73 citations

An ultrastructural analysis of early fertilization in the sand dollar, Echinarachnius parma

1974 • 72 citations

Electrical membrane properties of the Xenopus laevis oocyte during progesterone-induced meiotic maturation

1981 • 71 citations

Pronuclear Events during Fertilization

1985 • 70 citations

Phosphatidylinositol metabolism during fertilization in the sea urchin egg

1985 • 70 citations

Functions of Egg Cortical Granules

1985 • 70 citations

Effect on Sperm-Induced Activation Current and Increase of Cytosolic Ca2+by Agents That Modify the Mobilization of [Ca2+]i

1995 • 70 citations

Protein kinase C acts downstream of calcium at entry into the first mitotic interphase of Xenopus laevis.

1990 • 70 citations

Chapter 1 Sperm–Egg Fusion

1988 • 70 citations

Polyphosphoinositlde metabolism during the fertilization wave in sea urchin eggs

1992 • 68 citations

The electrical changes accompanying fertilization and cortical vesicle secretion in the medaka egg

1980 • 68 citations

Fertilization‐induced ionic conductances in eggs of the frog, Rana pipiens.

1985 • 68 citations

Electrical responses of immature and mature Rana pipiens oocytes to sperm and other activating stimuli

1981 • 68 citations

The development of mouse oocyte cortical reaction competence is accompanied by major changes in cortical vesicles and not cortical granule depth

1988 • 67 citations

Fertilization of immature frog eggs: cleavage and development following subsequent activation

1977 • 66 citations

Effects of Protein Tyrosine Kinase Inhibitors on Egg Activation and Fertilization-Dependent Protein Tyrosine Kinase Activity

1995 • 63 citations

Highly Polarized EGF Receptor Tyrosine Kinase Activity Initiates Egg Activation in Xenopus

1994 • 63 citations

Insemination of rabbit eggs is associated with slow depolarization and repetitive diphasic membrane potentials

1983 • 61 citations

Tyrosine phosphorylation of the egg receptor for sperm at fertilization

1994 • 60 citations

Voltage clamp studies of fertilization in sea urchin eggs

1988 • 59 citations

Repetitive Intracellular Ca2+ Increases at Fertilization and the Role of Ca2+ in Meiosis Reinitiation from the First Metaphase in Oocytes of Marine Bivalves

1994 • 57 citations

A synthetic peptide of the pseudosubstrate domain of protein kinase C blocks cytoplasmic alkalinization during activation of the sea urchin egg

1990 • 56 citations

Hydrozoan eggs can only be fertilized at the site of polar body formation

1982 • 55 citations

The role of divalent cations in activation of the sea urchin egg. I. Effect of fertilization on divalent cation content

1976 • 55 citations

Identification of an abl-related protein tyrosine kinase in the cortex of the sea urchin egg: Possible role at fertilization

1994 • 55 citations

The fertilization potential is not necessary for the block to polyspermy or the activation of development in the medaka egg

1980 • 55 citations

Identification of the sea urchin egg receptor for sperm using an antiserum raised against a fragment of its extracellular domain.

1992 • 54 citations

The sea urchin egg receptor for sperm: isolation and characterization of the intact, biologically active receptor

1993 • 54 citations

Calcium-triggered fusion of exocytotic granules requires proteins in only one membrane.

1992 • 54 citations

Electrical Responses of Eggs to Acrosomal Protein Similar to Those Induced by Sperm

1987 • 53 citations

Purification and characterization of an extracellular fragment of the sea urchin egg receptor for sperm.

1990 • 52 citations

Energetics of early development for the sea urchinsStrongylocentrotus purpuratus andLytechinus pictus and the crustaceanArtemia sp.

1990 • 52 citations

Proteins on exocytic vesicles mediate calcium-triggered fusion.

1992 • 51 citations

Studies of the mechanism of the electrical polyspermy block using voltage clamp during cross-species fertilization.

1982 • 51 citations

Structural Changes of the Endoplasmic Reticulum of Sea Urchin Eggs during Fertilization

1993 • 51 citations

Fusion of liposomes induced by a cationic protein from the acrosome granule of abalone spermatozoa

1986 • 49 citations

Visualization of exocytosis during sea urchin egg fertilization using confocal microscopy

1995 • 49 citations

ANIMAL/VEGETAL DIFFERENCES IN CORTICAL GRANULE EXOCYTOSIS DURING ACTIVATION OF THE FROG EGG*

1980 • 48 citations

Localized gating of egg Na+ channels by sperm

1981 • 48 citations

Protein tyrosine phosphorylation in response to fertilization.

1988 • 47 citations

Fast polyspermy block and activation potential

1979 • 47 citations

Activation by serotonin of starfish eggs expressing the rat serotonin 1c receptor.

1990 • 46 citations

The ability of hamster oolemma to fuse with spermatozoa: Its acquisition during oogenesis and loss after fertilization

1991 • 45 citations

Propagating potassium and chloride conductances during activation and fertilization of the egg of the frog, Rana pipiens.

1985 • 45 citations

Evidence that the voltage-dependent component in the fertilization process is contributed by the sperm

1989 • 45 citations

The Timing of Cortical Granule Fusion, Content Dispersal, and Endocytosis during Fertilization of the Hamster Egg: An Electrophysiological and Histochemical Study

1994 • 44 citations

Polarity of sperm entry in the ascidian egg

1989 • 41 citations

The calcium content of cortical granules and the loss of calcium from sea urchin eggs at fertilization

1991 • 39 citations

Peptides from sperm acrosomal protein that initiate egg development

1991 • 37 citations

Phosphoprotein inhibition of calcium-stimulated exocytosis in sea urchin eggs.

1991 • 35 citations

Characterization of sea urchin egg endoplasmic reticulum in cortical preparations

1991 • 35 citations

Changes at the hamster oocyte surface from the germinal vesicle stage to ovulation

1984 • 34 citations

Evidence for a polyspermy block at the level of sperm‐egg plasma membrane fusion in Urechis caupo

1976 • 34 citations

Freeze-fracture analysis of structural reorganization during meiotic maturation in oocytes of Xenopus laevis

1988 • 34 citations

Isolation of protein from Urechis sperm acrosomal granules that binds sperm to eggs and initiates development

1986 • 33 citations

Na+H+ antiport during fertilization of the sea urchin egg is blocked by W-7 but is insensitive to K252a and H-7

1989 • 33 citations

Sperm-induced currents at fertilization in sea urchin eggs injected with EGTA and neomycin

1992 • 32 citations

Differentiation of a calsequestrin-containing endoplasmic reticulum during sea urchin oogenesis

1990 • 31 citations

Proteases Stimulate Fertilization-like Responses in Starfish Eggs

1995 • 31 citations

Arousal of Activity in Sea Urchin Eggs at Fertilization

1989 • 31 citations

Activation of ascidian eggs with lectins

1980 • 29 citations

Ryanodine Activates Sea Urchin Eggs

1992 • 29 citations

Membrane depolarization facilitates sperm entry, large fertilization cone formation, and prolonged current responses in sea urchin oocytes

1987 • 29 citations

A calcium-activated sodium conductance contributes to the fertilization potential in the egg of the nemertean worm Cerebratulus lacteus

1986 • 29 citations

Synergistic release of calcium in sea urchin eggs by caffeine and ryanodine

1992 • 28 citations

Nuclear and Cytoplasmic pH Increase at Fertilization in Urechis caupo

1993 • 28 citations

Fertilization Membrane Formation in Sea Urchin Eggs Induced by Drugs Known to Cause Ca²⁺Release from Isolated Sarcoplasmic Reticulum

1990 • 27 citations

MEIOTIC MATURATION AND THE CORTICAL GRANULE REACTION IN STARFISH EGGS

1982 • 25 citations

The Fertilization Potential Provides a Fast Block to Polyspermy in Lamprey Eggs

1994 • 25 citations

Differential Emergence of Cortical Granule Breakdown and Electrophysiological Responses during Meiotic Maturation of Toad Oocytes. (activation potential/cortical granule breakdown/ionophore A23187/oocyte maturation)

1982 • 23 citations

A long-lasting electrically mediated block, due to the egg membrane hyperpolarization at fertilization, ensures physiological monospermy in eggs of the crab Maia squinado

1989 • 21 citations

Changes in voltage-dependent currents and membrane area during maturation of starfish oocytes: Species differences and similarities

1990 • 20 citations

A localized zone of increased conductance progresses over the surface of the sea urchin egg during fertilization.

1991 • 18 citations

Development and loss of the ability of mouse oolemma to fuse with spermatozoa

1994 • 17 citations

Activation of Na+-dependent transport at fertilization in the sea urchin: Requirements of both an early event associated with exocytosis and a later event involving increased energy metabolism

1985 • 16 citations

Signal Transduction During Biomembrane Fusion

1993 • 16 citations

Retention of hamster oolemma fusibility with spermatozoa after various enzyme treatments: a search for the molecules involved in sperm-egg fusion

1993 • 15 citations

The spike component of the fertilization potential in the toad, Bufo japonicus: Changes during meiotic maturation and absence during cross-fertilization

1987 • 14 citations

Fertilization acid of sea urchin eggs: Evidence that it is H+, not CO2

1982 • 13 citations

Mammalian eggs, sperm and fertilisation: dissimilar cells with a common goal

1993 • 13 citations

Chloride permeability of sea urchin eggs

1979 • 12 citations

Stages leading to and following fusion of sperm and egg plasma membranes

1994 • 11 citations

Analysis of sea urchin egg cortical transformation in the absence of cortical granule exocytosis

1985 • 10 citations

Src-related protein tyrosine kinases and T-cell receptor signalling

1992 • 10 citations

The decrease of Xenopus egg membrane capacity during activation might be due to endocytosis

1986 • 10 citations

Cell biology of fertilization.

1989 • 9 citations

Biology of the germ line : in animals and man

1993 • 8 citations

Signal Transduction of Gamete Interaction and Intracellular Calcium Release Mechanism at Fertilization of Mammalian Eggs

2015 • 7 citations

Chapter 3 Electrical Characteristics of Oocytes and Eggs

1991 • 4 citations