Classification of multiple morphine and enkephalin binding sites in the central nervous system.

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1975 • 3,780 citations

Endogenous opioid peptides: multiple agonists and receptors

1977 • 2,494 citations

Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine

1975 • 981 citations

Multiple opiate receptors. Enkephalins and morphine bind to receptors of different specificity.

1979 • 684 citations

Multiple opiate receptors: different regional distribution in the brain and differential binding of opiates and opioid peptides.

1979 • 399 citations

An endogenous morphine-like factor in mammalian brain

1975 • 393 citations

Isolation

1975 • 286 citations

Opiate Analgesia: Evidence for Mediation by a Subpopulation of Opiate Receptors

1980 • 249 citations

Differential effects of protein-modifying reagents on receptor binding of opiate agonists and antagonists.

1975 • 237 citations

Morphine-like peptides in mammalian brain: isolation, structure elucidation, and interactions with the opiate receptor.

1976 • 226 citations

Identification of novel high affinity opiate receptor binding in rat brain

1975 • 225 citations

Ontogeny of opioid pharmacology and receptors: High and low affinity site differences

1981 • 217 citations

Developmental differences between high and low affinity opiate binding sites: Their relationship to analgesia and respiratory depression

1980 • 174 citations

Naloxazone, a long-acting opiate antagonist: effects on analgesia in intact animals and on opiate receptor binding in vitro.

1980 • 170 citations

Opiate receptor binding: effects of enzymatic treatments.

1974 • 135 citations

Differential effects of protein-modifying reagents on receptor binding of opiate agonists and antagonists.

1975 • 111 citations

Long-acting opiate agonists and antagonists: 14-hydroxydihydromorphinone hydrazones

1980 • 103 citations

Multiple opiate receptors: [3H]ethylketocyclazocine receptor binding and ketocyclazocine analgesia.

1980 • 91 citations

Possible role of distinct morphine and enkephalin receptors in mediating actins of benzomorphan drugs (putative kappa and sigma agonists).

1980 • 71 citations

Opiates and enkephalins: A common binding site mediates their analgesic actions in rats

1981 • 68 citations

Multiple opiate receptors: phylogenetic differences

1981 • 63 citations

μ- and δ-opiate receptors: Correlation with high and low affinity opiate binding sites

1980 • 49 citations

Naloxazone irreversibly inhibits the high affinity binding of [125I]D-ala2-D-leu5-enkephalin

1981 • 48 citations

The actions of naloxazone on the binding and analgesic properties of morphiceptin (NH2 Tyr-Pro-Phe-Pro-CONH2), a selective mu-receptor ligand

1981 • 25 citations