Regulation of innate immunity by suppressor of cytokine signaling (SOCS) proteins

Pathogen Recognition and Innate Immunity

2006 • 11,197 citations

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

2007 • 2,524 citations

Innate Immunity: The Virtues of a Nonclonal System of Recognition

1997 • 2,397 citations

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

SOCS proteins, cytokine signalling and immune regulation

2007 • 1,450 citations

A new protein containing an SH2 domain that inhibits JAK kinases

1997 • 1,413 citations

Structure and function of a new STAT-induced STAT inhibitor

1997 • 1,308 citations

Circuitry of nuclear factor κB signaling

2006 • 861 citations

SOCS3 negatively regulates IL-6 signaling in vivo

2003 • 817 citations

SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine

1999 • 767 citations

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

2003 • 764 citations

SOCS-1 Participates in Negative Regulation of LPS Responses

2002 • 636 citations

How Toll-like receptors signal: what we know and what we don’t know

2005 • 630 citations

Regulation of NF-κB Signaling by Pin1-Dependent Prolyl Isomerization and Ubiquitin-Mediated Proteolysis of p65/RelA

2003 • 627 citations

SOCS1/JAB Is a Negative Regulator of LPS-Induced Macrophage Activation

2002 • 618 citations

Suppressors of cytokine signaling and immunity

2003 • 607 citations

Negative Regulation of Cytokine Signaling Pathways

2000 • 607 citations

Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue

2006 • 569 citations

SOCS1 Deficiency Causes a Lymphocyte-Dependent Perinatal Lethality

1999 • 531 citations

A Secreted Serine-Threonine Kinase Determines Virulence in the Eukaryotic Pathogen Toxoplasma gondii

2006 • 508 citations

Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation

2006 • 504 citations

Gigantism in mice lacking suppressor of cytokine signalling-2

2000 • 492 citations

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3

2004 • 489 citations

SOCS3 regulates the plasticity of gp130 signaling

2003 • 433 citations

Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1

1998 • 433 citations

The SOCS box: a tale of destruction and degradation

2002 • 409 citations

SOCS3 Exerts Its Inhibitory Function on Interleukin-6 Signal Transduction through the SHP2 Recruitment Site of gp130

2000 • 393 citations

Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock

2003 • 357 citations

Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent

2006 • 309 citations

IFN‐α antagonistic activity of HCV core protein involves induction of suppressor of cytokine signaling‐3

2003 • 304 citations

Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3

2001 • 302 citations

Autoregulation of pituitary corticotroph SOCS-3 expression: Characterization of the murine SOCS-3 promoter

1999 • 293 citations

SOCS3 Is a Critical Physiological Negative Regulator of G-CSF Signaling and Emergency Granulopoiesis

2004 • 277 citations

Suppressor of Cytokine Signaling (SOCS) Proteins Indirectly Regulate Toll-like Receptor Signaling in Innate Immune Cells

2004 • 267 citations

The Jak-Stat Pathway: Cytokine Signalling from the Receptor to the Nucleus

1999 • 263 citations

COMMD1 promotes the ubiquitination of NF-κB subunits through a cullin-containing ubiquitin ligase

2006 • 253 citations

Interactions of NF-κB with chromatin: the art of being at the right place at the right time

2005 • 251 citations

Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-gamma.

1999 • 245 citations

Inhibition of IFN-γ-Induced Class II Transactivator Expression by a 19-kDa Lipoprotein from Mycobacterium tuberculosis: A Potential Mechanism for Immune Evasion

2003 • 243 citations

Suppressors of Cytokine Signaling (SOCS)-1 and SOCS-3 Are Induced by CpG-DNA and Modulate Cytokine Responses in APCs

2001 • 242 citations

Suppressor of Cytokine Signaling-1 Is Essential for Suppressing Dendritic Cell Activation and Systemic Autoimmunity

2003 • 232 citations

Signaling by Type I and II cytokine receptors: ten years after

2001 • 206 citations

LPS and TNFα induce SOCS3 mRNA and inhibit IL‐6‐induced activation of STAT3 in macrophages

1999 • 205 citations

Lipopolysaccharide Induces in Macrophages the Synthesis of the Suppressor of Cytokine Signaling 3 and Suppresses Signal Transduction in Response to the Activating Factor IFN-γ

1999 • 191 citations

TLR pathways and IFN‐regulatory factors: To each its own

2007 • 182 citations

Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK–STAT

2005 • 173 citations

Implications of an antiparallel dimeric structure of nonphosphorylated STAT1 for the activation–inactivation cycle

2005 • 159 citations

The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo

2001 • 152 citations

Contribution of Interferon-β to the Murine Macrophage Response to the Toll-like Receptor 4 Agonist, Lipopolysaccharide

2006 • 148 citations

Re-examination of the Role of Suppressor of Cytokine Signaling 1 (SOCS1) in the Regulation of Toll-like Receptor Signaling

2004 • 148 citations

IκBNS Inhibits Induction of a Subset of Toll-like Receptor-Dependent Genes and Limits Inflammation

2006 • 144 citations

Lipopolysaccharide or Whole Bacteria Block the Conversion of Inflammatory Monocytes into Dendritic Cells In Vivo

2003 • 114 citations

Induction of Suppressor of Cytokine Signaling-1 byToxoplasma gondiiContributes to Immune Evasion in Macrophages by Blocking IFN-γ Signaling

2006 • 105 citations

Negative Regulation of Cytokine and TLR Signalings by SOCS and Others

2005 • 100 citations

Indirect induction of suppressor of cytokine signalling-1 in macrophages stimulated with bacterial lipopolysaccharide: partial role of autocrine/paracrine interferon-α/β

2000 • 98 citations

Mycobacterium bovisbacillus Calmette-Guérin infection promotes SOCS induction and inhibits IFN-γ-stimulated JAK/STAT signaling in J774 macrophages

2003 • 72 citations

The MKK6/p38 Mitogen-Activated Protein Kinase Pathway Is Capable of Inducing SOCS3 Gene Expression and Inhibits IL-6-Induced Transcription

2001 • 71 citations

Regulation of SOCS-1 Expression by Translational Repression

2000 • 70 citations

SOC1 inhibits HPV-E7-mediated transformation by inducing degradation of E7 protein

2004 • 69 citations

Leishmania donovani-Induced Expression of Suppressor of Cytokine Signaling 3 in Human Macrophages: a Novel Mechanism for Intracellular Parasite Suppression of Activation

2003 • 69 citations

Triggering of Toll‐like receptors modulates IFN‐γ signaling: involvement of serine 727 STAT1 phosphorylation and suppressors of cytokine signaling

2003 • 62 citations

Involvement of suppressors of cytokine signaling in toll-like receptor–mediated block of dendritic cell differentiation

2006 • 62 citations

Signal Integration Following Toll-like Receptor Triggering

2002 • 52 citations

Indirect induction of suppressor of cytokine signalling-1 in macrophages stimulated with bacterial lipopolysaccharide: partial role of autocrine/paracrine interferon-α/β

2000 • 52 citations

Early Growth Response-1 Regulates Lipopolysaccharide-induced Suppressor of Cytokine Signaling-1 Transcription

2004 • 43 citations

Differential Effects of CpG DNA on IFN-β Induction and STAT1 Activation in Murine Macrophages versus Dendritic Cells: Alternatively Activated STAT1 Negatively Regulates TLR Signaling in Macrophages

2007 • 43 citations

TLR-induced negative regulatory circuits: role of suppressor of cytokine signaling (SOCS) proteins in innate immunity

2003 • 31 citations

Persistence of Lesions in Suppressor of Cytokine Signaling-1-Deficient Mice Infected with Leishmania major

2003 • 29 citations

Synergistic and antagonistic interactions between LPS and superantigens

2003 • 26 citations

Synergistic and antagonistic interactions between LPS and superantigens

2003 • 20 citations

Recent research developments in immunology

2004 • 14 citations

Suppressors of cytokine signaling proteins in innate and adaptive immune responses.

2003 • 12 citations