LPS and TNFα induce SOCS3 mRNA and inhibit IL‐6‐induced activation of STAT3 in macrophages

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human

1999 • 2,692 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

1991 • 2,362 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

1998 • 2,072 citations

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter.

1990 • 615 citations

IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice.

1989 • 578 citations

Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level.

1993 • 543 citations

Interleukin-10 Inhibits Expression of Both Interferon – and Interferon γ– Induced Genes by Suppressing Tyrosine Phosphorylation of STAT1

1999 • 397 citations

Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-gamma.

1999 • 245 citations

Stat1 combines signals derived from IFN-gamma and LPS receptors during macrophage activation

1998 • 240 citations

Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases

1998 • 227 citations

Lipopolysaccharide Induces in Macrophages the Synthesis of the Suppressor of Cytokine Signaling 3 and Suppresses Signal Transduction in Response to the Activating Factor IFN-γ

1999 • 191 citations

Role of anion translocation across the mitochondrial membrane in the regulation of urea synthesis from ammonia by isolated rat hepatocytes.

1975 • 189 citations

Endotoxin-induced cytokine gene expression in vivo. III. IL-6 mRNA and serum protein expression and the in vivo hematologic effects of IL-6.

1991 • 154 citations

Rat hepatic sinusoidal endothelial cells in monolayer culture

1988 • 145 citations

The biological effects of interleukin 6

1996 • 142 citations

Single‐step purification and structural characterization of human interleukin‐6 produced in Esherichia coli From a T7 RNA polymerase expression vector

1991 • 139 citations

Inhibition of cytokines and JAK-STAT activation by distinct signaling pathways.

1996 • 129 citations

TGF-beta inhibits IL-2-induced tyrosine phosphorylation and activation of Jak-1 and Stat 5 in T lymphocytes.

1997 • 127 citations

Apoptosis of Neutrophils and Their Elimination by Kupffer Cells in Rat Liver

1996 • 93 citations

Interleukin-6 inhibits the proliferation of B-chronic lymphocytic leukemia cells that is induced by tumor necrosis factor-alpha or -beta

1993 • 77 citations

Mechanism of inhibition of eosinophil activation by transforming growth factor-beta. Inhibition of Lyn, MAP, Jak2 kinases and STAT1 nuclear factor.

1995 • 77 citations

Activation of Protein Kinase A Inhibits Interferon Induction of the Jak/Stat Pathway in U266 Cells

1996 • 72 citations

Inhibition of Alpha Interferon but Not Gamma Interferon Signal Transduction by Phorbol Esters Is Mediated by a Tyrosine Phosphatase

1996 • 46 citations

Angiotensin II Interferes with Interleukin 6-induced Stat3 Signaling by a Pathway Involving Mitogen-activated Protein Kinase Kinase 1

1996 • 35 citations

ATP Depletion Affects the Phosphorylation State, Ligand Binding, and Nuclear Transport of the 4 S Polycyclic Aromatic Hydrocarbon-binding Protein in Rat Hepatoma Cells

1996 • 33 citations

Lipopolysaccharide stimulates HepG2 human hepatoma cells in the presence of lipopolysaccharide‐binding protein via CD14

1999 • 29 citations

Inhibitory role of interleukin-6 in macrophage proliferation

1992 • 27 citations