Stimulus-response coupling: the search for intracellular calcium mediator proteins.

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

INTRACELLULAR CALCIUM HOMEOSTASIS

1987 • 2,183 citations

Calcium and muscle contraction

1968 • 1,745 citations

A further Contribution regarding the influence of the different Constituents of the Blood on the Contraction of the Heart

1883 • 941 citations

The calcium and magnesium binding sites on troponin and their role in the regulation of myofibrillar adenosine triphosphatase.

1975 • 917 citations

Ca2+-induced hydrophobic site on calmodulin: Application for purification of calmodulin by phenyl-Sepharose affinity chromatography

1982 • 877 citations

Cyclic 3′,5′-nucleotide phosphodiesterase

1970 • 824 citations

ENZYME SECRETION AND THE INCORPORATION OF P32 INTO PHOSPHOLIPIDES OF PANCREAS SLICES

1953 • 757 citations

Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis

1987 • 668 citations

Movements of labelled calcium in squid giant axons

1957 • 668 citations

Measurement of cytosolic free Ca2+ in individual small cells using fluorescence microscopy with dual excitation wavelengths

1985 • 660 citations

Reconstitution of Troponin Activity from Three Protein Components

1971 • 594 citations

Identity of p36K phosphorylated upon Rous sarcoma virus transformation with a protein purified from brush borders; calcium-dependent binding to non-erythroid spectrin and F-actin.

1984 • 541 citations

Intracellular calcium; its universal role as regulator

1984 • 500 citations

Physicochemical properties of rat testis Ca2+-dependent regulator protein of cyclic nucleotide phosphodiesterase. Relationship of Ca2+-binding, conformational changes, and phosphodiesterase activity

1977 • 459 citations

"Calciosome," a cytoplasmic organelle: the inositol 1,4,5-trisphosphate-sensitive Ca2+ store of nonmuscle cells?

1988 • 451 citations

Aggregation of chromaffin granules by calpactin at micromolar levels of calcium

1988 • 443 citations

Refinement of the structure of carp muscle calcium-binding parvalbumin by model building and difference fourier analysis

1975 • 433 citations

Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells

1989 • 423 citations

Isolation of the yeast calmodulin gene: Calmodulin is an essential protein

1986 • 400 citations

Diversity in the lipocortin/calpactin family

1988 • 376 citations

Isolation of a calcium-dependent 35-kilodalton substrate for the epidermal growth factor receptor/kinase from A-431 cells.

1984 • 366 citations

Five distinct calcium and phospholipid binding proteins share homology with lipocortin I.

1988 • 364 citations

Striated flagellar roots: isolation and partial characterization of a calcium-modulated contractile organelle.

1984 • 359 citations

Evolutionary origin of a calcium-dependent protease by fusion of genes for a thiol protease and a calcium-binding protein?

1984 • 337 citations

A Synaptic Vesicle Protein with a Novel Cytoplasmic Domain and Four Transmembrane Regions

1987 • 326 citations

Yeast gene required for spindle pole body duplication: homology of its product with Ca2+-binding proteins.

1986 • 321 citations

Molecular characterization of synaptophysin, a major calcium-binding protein of the synaptic vesicle membrane.

1986 • 296 citations

Amino-terminal sequence of p36 and associated p10: identification of the site of tyrosine phosphorylation and homology with S-100.

1985 • 268 citations

Molecular cloning of the cDNA for a growth factor-inducible gene with strong homology to S-100, a calcium-binding protein.

1986 • 265 citations

The regulatory chain in the p36-kd substrate complex of viral tyrosine-specific protein kinases is related in sequence to the S-100 protein of glial cells.

1985 • 252 citations

Characterization of Ca2+-dependent phospholipid binding and phosphorylation of lipocortin I.

1987 • 236 citations

Purification and Partial Characterization of a Highly Immunogenic Human Leukocyte Protein, the L1 Antigen

1983 • 231 citations

Molecular cloning of cDNA for caltractin, a basal body-associated Ca2+-binding protein: homology in its protein sequence with calmodulin and the yeast CDC31 gene product.

1988 • 219 citations

Synaptophysin: molecular organization and mRNA expression as determined from cloned cDNA.

1987 • 205 citations

Calcium‐sensitive non‐muscle α‐actinin contains EF‐hand structures and highly conserved regions

1987 • 205 citations

Molecular Cloning of the Mammalian Smooth Muscle Sarco(endo)plasmic Reticulum Ca2+-ATPase

1989 • 204 citations

Ca2+-dependent hydrophobic-interaction chromatography. Isolation of a novel Ca2+-binding protein and protein kinase C from bovine brain

1984 • 202 citations

Cyclic 3′,5′-nucleotide phosphodiesterase. Distribution and developmental changes of the enzyme and its protein activator in mammalian tissues and cells

1974 • 198 citations

p36, the major cytoplasmic substrate of src tyrosine protein kinase, binds to its p11 regulatory subunit via a short amino-terminal amphiphatic helix.

1988 • 193 citations

Calcium-Induced Contraction of the Rhizoplast of a Quadriflagellate Green Alga

1978 • 185 citations

Regulation of calpactin I phospholipid binding by calpactin I light-chain binding and phosphorylation by p60v-src

1987 • 184 citations

The sequence of chick alpha-actinin reveals homologies to spectrin and calmodulin.

1987 • 173 citations

Calcium-dependent protein binding to phenothiazine columns.

1982 • 159 citations

Calcium channel activity of purified human synexin and structure of the human synexin gene.

1989 • 153 citations

Calcium binding to complexes of calmodulin and calmodulin binding proteins

1985 • 152 citations

Nerve growth factor induces the genes for two proteins related to a family of calcium-binding proteins in PC12 cells.

1988 • 148 citations

Common domain structure of Ca²⁺ and lipid‐binding proteins

1986 • 138 citations

A 22-kd protein (sorcin/V19) encoded by an amplified gene in multidrug-resistant cells, is homologous to the calcium-binding light chain of calpain.

1986 • 137 citations

Identification and localization of a novel, cytoskeletal, centrosome-associated protein in PtK2 cells.

1988 • 129 citations

Cloning and sequence analysis of cDNA encoding p38, a major synaptic vesicle protein.

1987 • 128 citations

Increased synthesis of a low molecular weight protein in vincristine-resistant cells

1981 • 121 citations

Enhancement of Calcium Sensitivity of Lipocortin I in Phospholipid Binding Induced by Limited Proteolysis and Phosphorylation at the Amino Terminus as Analyzed by Phospholipid Affinity Column Chromatography

1989 • 120 citations

Purification of a Calcium-binding Phosphoprotein from Pig Brain

1972 • 113 citations

A growth-related mRNA in cultured mouse cells encodes a placental calcium binding protein

1987 • 109 citations

The Leucocyte L1 Protein: Identity with the Cystic Fibrosis Antigen and the Calcium‐Binding MRP‐8 and MRP‐14 Macrophage Components

1988 • 109 citations

Molecular cloning and sequence of the gene for p9Ka a cultured myoepithelial cell protein with strong homology to S-100, a calcium-binding protein

1987 • 105 citations

Isolation and sequence analysis of cDNA clones for the small subunit of rabbit calcium-dependent protease.

1986 • 103 citations

Isolation of a new member of the S100 protein family: amino acid sequence, tissue, and subcellular distribution.

1989 • 95 citations

Isolation from Cholinergic Synapses of a Protein That Binds to Membranes in a Calcium‐Dependent Manner

1982 • 93 citations

Immunocytochemistry of calciosomes in liver and pancreas.

1988 • 93 citations

Cut, paste, and save: New approaches to altering specific genes in mice

1989 • 92 citations

Ca2+-binding proteins from bovine brain including a potent inhibitor of protein kinase C

1985 • 91 citations

A putative Ca2+-binding protein: structure of the light subunit of porcine calpain elucidated by molecular cloning and protein sequence analysis.

1985 • 91 citations

The 28-kDa vitamin D-dependent calcium-binding protein has a six-domain structure.

1986 • 91 citations

Cloning and characterization of a cDNA encoding a highly conserved, putative calcium binding protein, identified by an anti-prolactin receptor antiserum.

1988 • 89 citations

Nucleotide sequence of the CLS4 (CDC24) gene of Saccharomyces cerevisiae

1987 • 86 citations

Cloning of the Sequences Expressed Abundantly in Established Cell Lines: Identification of a cDNA Clone Highly Homologous to S-100, a Calcium Binding Protein1

1988 • 84 citations

Evidence for the presence of phospholamban in the endoplasmic reticulum of smooth muscle

1986 • 78 citations

Novel proteins belonging to the troponin C superfamily are encoded by a set of mRNAs in sea urchin embryos

1984 • 74 citations

Calcium‐Dependent Binding of Cytosolic Proteins by Chromaffin Granules from Adrenal Medulla

1982 • 73 citations

Purification of the Mr 22,000 calcium-binding protein (sorcin) associated with multidrug resistance and its detection with monoclonal antibodies.

1988 • 58 citations

Smooth-muscle endoplasmic reticulum contains a cardiac-like form of calsequestrin

1987 • 55 citations

Identification of a novel calcium‐binding protein (CP₂₂) in multidrug‐resistant murine and hamster cells

1986 • 53 citations

Homology between the subunits of S100 and a 10kDa polypeptide associated with p36 of pig lymphocytes

1986 • 46 citations

Secretory vesicle — Cytosol interactions in exocytosis: Isolation by Ca2+-dependent affinity chromatography of proteins that bind to the chromaffin granule membrane

1981 • 44 citations

Calcium binding and fluorescence measurements of dansylaziridine-labelled troponin C in reconstituted thin filaments

1987 • 43 citations

Synhibin: A new calcium‐dependent membrane‐binding protein that inhibits synexin‐induced chromaffin granule aggregation and fusion

1982 • 35 citations

Localization of phospholamban in smooth muscle using immunogold electron microscopy.

1988 • 32 citations

Isolation and characterization of a new Mr 18,000 protein with calcium vector properties in amphioxus muscle and identification of its endogenous target protein.

1986 • 29 citations

Homology of Calcium-Modulated Proteins: Their Evolutionary and Functional Relationships

1988 • 28 citations

Identification of bovine brain Ca2+-binding proteins

1985 • 25 citations

The primary structure of a new Mr 18,000 calcium vector protein from amphioxus.

1987 • 23 citations

High-level expression in Escherichia coli of calcium-binding domains of an embryonic sea urchin protein

1984 • 22 citations

Two low-molecular-weight Ca2+-binding proteins isolated from squid optic lobe by phenothiazine-Sepharose affinity chromatography

1983 • 20 citations

Mouse placental 57-kDa calcium-binding protein: II. Localization of mRNA in mouse and human placentae by in situ cDNA hybridization

1988 • 19 citations

Amino acid sequence of a low molecular weight, high affinity calcium-binding protein from the optic lobe of the squid Loligo pealei

1989 • 11 citations

Identification of bovine brain calcium binding proteins

1987 • 5 citations

Cytoskeletal proteins of lymphocyte plasma membrane

1981 • 4 citations