Pattern formation in the Drosophila eye disc

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

DEVELOPMENT IN DROSOPHILA MELANOGASTER

1927 • 2,909 citations

Development of the Drosophila retina, a neurocrystalline lattice

1976 • 1,028 citations

Dual Roles for Patched in Sequestering and Transducing Hedgehog

1996 • 889 citations

Reiterative Use of the EGF Receptor Triggers Differentiation of All Cell Types in the Drosophila Eye

1996 • 879 citations

The activities of two Ets-related transcription factors required for drosophila eye development are modulated by the Ras/MAPK pathway

1994 • 690 citations

Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor

1997 • 658 citations

Induction of Drosophila eye development by Decapentaplegic

1997 • 567 citations

Neuronal differentiation in the Drosophila ommatidium

1987 • 532 citations

The drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system

1994 • 513 citations

atonal is the proneural gene for Drosophila photoreceptors

1994 • 498 citations

Notch is required for successive cell decisions in the developing Drosophila retina.

1989 • 473 citations

The emergence of order in the Drosophila pupal retina

1989 • 439 citations

The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates

1990 • 430 citations

The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye

1993 • 423 citations

The TGFβ homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina

1993 • 414 citations

The beginning of pattern formation in theDrosophilacompound eye: the morphogenetic furrow and the second mitotic wave

1991 • 397 citations

Hedgehog Controls Limb Development by Regulating the Activities of Distinct Transcriptional Activator and Repressor Forms of Cubitus interruptus

1999 • 374 citations

Sending and Receiving the Hedgehog Signal: Control by the Drosophila Gli Protein Cubitus interruptus

1996 • 320 citations

Role of the proneural gene, atonal, in formation of Drosophila chordotonal organs and photoreceptors

1995 • 317 citations

Cell determination strategies in the Drosophila eye

1997 • 308 citations

The homeo domain protein rough is expressed in a subset of cells in the developing Drosophila eye where it can specify photoreceptor cell subtype.

1990 • 267 citations

Spacing Differentiation in the Developing Drosophila Eye: a Fibrinogen-related Lateral Inhibitor Encoded by scabrous

1990 • 264 citations

Combinatorial Signaling in the Specification of Unique Cell Fates

2000 • 260 citations

Isolation and expression of scabrous, a gene regulating neurogenesis in Drosophila.

1990 • 256 citations

Hedgehog, Transmitted along Retinal Axons, Triggers Neurogenesis in the Developing Visual Centers of the Drosophila Brain

1996 • 255 citations

A dorsal/ventral boundary established by Notch controls growth and polarity in the Drosophila eye

1998 • 254 citations

Inhibition of Drosophila EGF receptor activation by the secreted protein Argos

1995 • 251 citations

Pattern-specific expression of the Drosophila decapentaplegic gene in imaginal disks is regulated by 3' cis-regulatory elements.

1990 • 250 citations

Glass encodes a site-specific DNA-binding protein that is regulated in response to positional signals in the developing Drosophila eye.

1991 • 248 citations

Creating a Drosophila wing de novo, the role of engrailed, and the compartment border hypothesis

1995 • 246 citations

Determination of Neuronal Cell Fate: Lessons from the R7 Neuron of Drosophila

1994 • 245 citations

The argos gene encodes a diffusible factor that regulates cell fate decisions in the drosophila eye

1992 • 238 citations

Dual Bar homeo box genes of Drosophila required in two photoreceptor cells, R1 and R6, and primary pigment cells for normal eye development.

1992 • 237 citations

argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop

1996 • 235 citations

Combinatorial control of Drosophila eye development by Eyeless, Homothorax, and Teashirt

2002 • 233 citations

Signaling by the Drosophila epidermal growth factor receptor pathway during development

2003 • 232 citations

wingless inhibits morphogenetic furrow movement in the Drosophila eye disc

1995 • 229 citations

Dorsal-Ventral Signaling in the Drosophila Eye

1998 • 228 citations

A Hedgehog-Induced BTB Protein Modulates Hedgehog Signaling by Degrading Ci/Gli Transcription Factor

2006 • 225 citations

Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye

1996 • 223 citations

Multiple functions of the EGF receptor in Drosophila eye development

1998 • 210 citations

wingless and patched are negative regulators of the morphogenetic furrow and can affect tissue polarity in the developing Drosophila compound eye

1995 • 210 citations

Progression of the morphogenetic furrow in the Drosophila eye: the roles of Hedgehog, Decapentaplegic and the Raf pathway

1999 • 207 citations

Growth and differentiation in the Drosophila eye coordinated by hedgehog

1995 • 199 citations

Notch signalling inDrosophila: three ways to use a pathway

1998 • 195 citations

Patterning of cells in the Drosophila eye by Lozenge, which shares homologous domains with AML1.

1996 • 187 citations

Signaling circuitries in development: insights from the retinal determination gene network

2004 • 187 citations

Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development

2002 • 184 citations

Fringe is essential for mirror symmetry and morphogenesis in the Drosophila eye

1998 • 183 citations

Regulating the dynamics of EGF receptor signaling in space and time

2005 • 181 citations

ZLocal induction of patterning and programmed cell death in the developing Drosophila retina

1998 • 180 citations

Hedgehog directly controls initiation and propagation of retinal differentiation in the Drosophila eye

1997 • 178 citations

A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling

2000 • 177 citations

Evolution of proneural atonal expression during distinct regulatory phases in the developing Drosophila eye

1996 • 176 citations

Morphogenetic furrow initiation and progression during eye development in Drosophila: the roles of decapentaplegic, hedgehog and eyes absent

2000 • 175 citations

An EGFR/Ebi/Sno Pathway Promotes Delta Expression by Inactivating Su(H)/SMRTER Repression during Inductive Notch Signaling

2002 • 174 citations

The ubiquitin ligase Hyperplastic discs negatively regulateshedgehoganddecapentaplegicexpression by independent mechanisms

2002 • 174 citations

Making Connections in the Fly Visual System

2002 • 171 citations

Mechanisms of drosophila retinal morphogenesis: The virtues of being progressive

1995 • 167 citations

Overlapping Activators and Repressors Delimit Transcriptional Response to Receptor Tyrosine Kinase Signals in the Drosophila Eye

2000 • 157 citations

The spitz gene is required for photoreceptor determination in the Drosophila eye where it interacts with the EGF receptor

1994 • 155 citations

Coordinating Proliferation and Tissue Specification to Promote Regional Identity in the Drosophila Head

2003 • 155 citations

Genetic and Molecular Bases of Neurogenesis in Drosophila Melanogaster

1991 • 152 citations

Hairy and Emc negatively regulate morphogenetic furrow progression in the drosophila eye

1995 • 149 citations

Compartments and organising boundaries in the Drosophila eye: the role of the homeodomain Iroquois proteins

1999 • 147 citations

Role of decapentaplegic in initiation and progression of the morphogenetic furrow in the developing Drosophila retina

1997 • 147 citations

Transcriptional regulation of atonal during development of the Drosophila peripheral nervous system

1998 • 144 citations

Notch signalling and the initiation of neural development in theDrosophilaeye

2001 • 139 citations

Atonal, Rough and the resolution of proneural clusters in the developing Drosophila retina

1996 • 138 citations

Argos inhibits epidermal growth factor receptor signalling by ligand sequestration

2004 • 138 citations

Relationships between complex Delta expression and the specification of retinal cell fates during Drosophila eye development

1995 • 135 citations

Control of Cell Proliferation in the Drosophila Eye by Notch Signaling

2005 • 134 citations

Novel Signaling from the Peripodial Membrane Is Essential for Eye Disc Patterning in Drosophila

2000 • 131 citations

senseless Repression of rough Is Required for R8 Photoreceptor Differentiation in the Developing Drosophila Eye

2001 • 128 citations

R8 development in theDrosophilaeye: a paradigm for neural selection and differentiation

2002 • 128 citations

A Retinal Axon Fascicle Uses Spitz, an EGF Receptor Ligand, to Construct a Synaptic Cartridge in the Brain of Drosophila

1998 • 127 citations

The Drosophila TGFα homolog Spitz acts in photoreceptor recruitment in the developing retina

1997 • 124 citations

Proneural function of neurogenic genes in the developing Drosophila eye

1997 • 124 citations

glial cells missing and gcm2 Cell Autonomously Regulate Both Glial and Neuronal Development in the Visual System of Drosophila

2005 • 122 citations

Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus

2006 • 121 citations

Dual role for Hedgehog in the regulation of the proneural gene atonal during ommatidia development

1999 • 120 citations

act up Controls Actin Polymerization to Alter Cell Shape and Restrict Hedgehog Signaling in the Drosophila Eye Disc

2000 • 120 citations

Delta/Notch and Boss/Sevenless Signals Act Combinatorially to Specify the Drosophila R7 Photoreceptor

2001 • 117 citations

Hedgehog Signaling Is a Principal Inducer of Myosin-II-Driven Cell Ingression in Drosophila Epithelia

2007 • 115 citations

Myosin II Regulates Complex Cellular Arrangement and Epithelial Architecture in Drosophila

2007 • 114 citations

Growth and Differentiation

1967 • 113 citations

Palmitoylation of the EGFR Ligand Spitz by Rasp Increases Spitz Activity by Restricting Its Diffusion

2006 • 111 citations

Drosophila eye development: Notch and Delta amplify a neurogenic pattern conferred on the morphogenetic furrow by scabrous

1995 • 110 citations

Signals transmitted along retinal axons in Drosophila: Hedgehog signal reception and the cell circuitry of lamina cartridge assembly

1998 • 105 citations

spitz, a Drosophila homolog of transforming growth factor-α, is required in the founding photoreceptor cells of the compound eye facets

1994 • 100 citations

A primary role for the epidermal growth factor receptor in ommatidial spacing in the Drosophila eye

2001 • 92 citations

Identifying targets of the rough homeobox gene of Drosophila: evidence that rhomboid functions in eye development

1992 • 90 citations

Regulation of EGF receptor signaling establishes pattern across the developing Drosophila retina

1998 • 90 citations

ThescabrousGene Encodes a Secreted Glycoprotein Dimer and Regulates Proneural Development inDrosophilaEyes

1996 • 89 citations

Scabrous complexes with Notch to mediate boundary formation

2001 • 87 citations

Identification of Regulatory Regions Driving the Expression of the Drosophila spalt Complex at Different Developmental Stages

1999 • 87 citations

Identification of functionalsine oculismotifs in the autoregulatory element of its own gene, in theeyelessenhancer and in the signalling genehedgehog

2005 • 86 citations

Lozenge is expressed in pluripotent precursor cells and patterns multiple cell types in the Drosophila eye through the control of cell-specific transcription factors

1998 • 86 citations

The EGF receptor and notch signaling pathways control the initiation of the morphogenetic furrow duringDrosophilaeye development

2001 • 83 citations

JAK/STAT signaling promotes regional specification by negatively regulatingwinglessexpression inDrosophila

2006 • 83 citations

A conserved developmental program for sensory organ formation in Drosophila melanogaster

2004 • 82 citations

Mechanism ofhedgehogsignaling duringDrosophilaeye development

2003 • 80 citations

Deciphering synergistic and redundant roles of Hedgehog, Decapentaplegic and Delta that drive the wave of differentiation inDrosophilaeye development

2003 • 75 citations

Hedgehog-Dependent Patterning in theDrosophilaEye Can Occur in the Absence of Dpp Signaling

1996 • 73 citations

Role of the EGFR/Ras/Raf pathway in specification of photoreceptor cells in the Drosophila retina

2001 • 72 citations

Cell-fate determination in the developing Drosophila eye: role of the rough gene

1991 • 70 citations

Combinatorial signaling in the specification of primary pigment cells in theDrosophilaeye

2007 • 70 citations

Conservation and non-conservation of genetic pathways in eye specification

2004 • 69 citations

A transcriptional chain linking eye specification to terminal determination of cone cells in the Drosophila eye

2003 • 66 citations

Star Is Required for Neuronal Differentiation in the Drosophila Retina and Displays Dosage-Sensitive Interactions with Ras1

1993 • 63 citations

scabrous Modifies Epithelial Cell Adhesion and Extends the Range of Lateral Signalling during Development of the Spaced Bristle Pattern in Drosophila

2001 • 58 citations

Two-step selection of a single R8 photoreceptor: a bistable loop betweensenselessandroughlocks in R8 fate

2008 • 58 citations

Developmental roles of heparan sulfate proteoglycans: a comparative review in Drosophila, mouse and human.

2002 • 56 citations

Drosophila Eye Development

2002 • 56 citations

Negative regulation of atonal in proneural cluster formation of Drosophila R8 photoreceptors

1999 • 52 citations

Pointed regulates an eye-specific transcriptional enhancer in theDrosophila hedgehoggene, which is required for the movement of the morphogenetic furrow

2005 • 52 citations

The R8-photoreceptor equivalence group in Drosophila: fate choice precedes regulated Delta transcription and is independent of Notch gene dose

1998 • 48 citations

Star is required in a subset of photoreceptor cells in the developing Drosophila retina and displays dosage sensitive interactions with rough

1991 • 44 citations

The highly ordered assembly of retinal axons and their synaptic partners is regulated by Hedgehog/Single-minded in theDrosophilavisual system

2006 • 43 citations

Upd/Jak/STAT signaling represses wg transcription to allow initiation of morphogenetic furrow in Drosophila eye development

2007 • 43 citations

Computational analysis of EGFR inhibition by Argos

2005 • 42 citations

Odd-skipped genes specify the signaling center that triggers retinogenesis inDrosophila

2006 • 41 citations

A C-Terminal Motif Targets Hedgehog to Axons, Coordinating Assembly of the Drosophila Eye and Brain

2006 • 39 citations

Small Wing PLCγ Is Required for ER Retention of Cleaved Spitz during Eye Development in Drosophila

2004 • 38 citations

Ommatidial polarity in the Drosophila eye is determined by the direction of furrow progression and local interactions

1995 • 37 citations

Scabrous and Gp150 are endosomal proteins that regulate Notch activity

2003 • 37 citations

Epithelial cell adhesion in the developing Drosophila retina is regulated by Atonal and the EGF receptor pathway

2006 • 36 citations

Hedgehog and Dpp signaling induce cadherin Cad86C expression in the morphogenetic furrow during Drosophila eye development

2008 • 32 citations

Control of cell proliferation

1977 • 30 citations

Bar homeodomain proteins are anti-proneural in theDrosophilaeye: transcriptional repression ofatonalby Bar prevents ectopic retinal neurogenesis

2003 • 28 citations

Induction and autoregulation of the anti-proneural geneBarduring retinal neurogenesis inDrosophila

2004 • 28 citations

Genetic and biochemical analysis of the role of Egfr in the morphogenetic furrow of the developingDrosophilaeye

2005 • 26 citations

Novel function of the class I bHLH protein Daughterless in the negative regulation of proneural gene expression in the Drosophila eye

2008 • 25 citations

Suppression of Hedgehog signaling by Cul3 ligases in proliferation control of retinal precursors

2007 • 23 citations

Groucho mediates a Ci-independent mechanism ofhedgehogrepression in the anterior wing pouch

2001 • 18 citations

The CNS midline cells control the spitz class and Egfr signaling genes to establish the proper cell fate of the Drosophila ventral neuroectoderm.

2001 • 16 citations

Signaling by the Drosophila epidermal growth factor receptor pathway during development

2003 • 16 citations

The CNS midline cells and spitz class genes are required for proper patterning of Drosophila ventral neuroectoderm.

1999 • 15 citations

Cell‐type specific utilization of multiple negative feedback loops generates developmental constancy

2005 • 14 citations

Determination of Neuronal Cell Fate: Lessons From the R7 Neuron of Drosophila

1994 • 14 citations

Diversification of cell types in the Drosophila eye by differential expression of prepattern genes

2001 • 11 citations

The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway

1994 • 9 citations

Genetic And Molecular Bases Of Neurogenesis In Drosophila Melanogaster

1991 • 6 citations

The role of homeotic genes in determining the segmental pattern of chordotonal organs in Drosophila.

2002 • 5 citations