Mechanism ofhedgehogsignaling duringDrosophilaeye development

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

Hedgehog signaling in animal development: paradigms and principles

2001 • 2,919 citations

DEVELOPMENT IN DROSOPHILA MELANOGASTER

1927 • 2,909 citations

Mosaic Analysis with a Repressible Cell Marker for Studies of Gene Function in Neuronal Morphogenesis

1999 • 2,521 citations

Analysis of genetic mosaics in developing and adult Drosophila tissues

1993 • 2,029 citations

Induction of Ectopic Eyes by Targeted Expression of the eyeless Gene in Drosophila

1995 • 1,563 citations

Homology of the eyeless Gene of Drosophila to the Small eye Gene in Mice and Aniridia in Humans

1994 • 1,075 citations

Development of the Drosophila retina, a neurocrystalline lattice

1976 • 1,028 citations

Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein

1994 • 842 citations

Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor

1997 • 658 citations

The Eye-Specification Proteins So and Eya Form a Complex and Regulate Multiple Steps in Drosophila Eye Development

1997 • 587 citations

Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

1992 • 585 citations

Induction of Drosophila eye development by Decapentaplegic

1997 • 567 citations

The eyes absent gene: Genetic control of cell survival and differentiation in the developing Drosophila eye

1993 • 557 citations

dachshund encodes a nuclear protein required for normal eye and leg development in Drosophila

1994 • 527 citations

The drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system

1994 • 513 citations

Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E

2002 • 430 citations

The TGFβ homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina

1993 • 414 citations

The beginning of pattern formation in theDrosophilacompound eye: the morphogenetic furrow and the second mitotic wave

1991 • 397 citations

Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development

1998 • 387 citations

Dachshund and Eyes Absent Proteins Form a Complex and Function Synergistically to Induce Ectopic Eye Development in Drosophila

1997 • 383 citations

Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.

1996 • 380 citations

Hedgehog Controls Limb Development by Regulating the Activities of Distinct Transcriptional Activator and Repressor Forms of Cubitus interruptus

1999 • 374 citations

Patterning of the Zebrafish Retina by a Wave of Sonic Hedgehog Activity

2000 • 373 citations

Cell fate in the Drosophila ommatidium

1987 • 363 citations

Decapentaplegic: A gene complex affecting morphogenesis in Drosophila melanogaster

1982 • 345 citations

Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity

2002 • 313 citations

The Drosophila eyes absent gene directs ectopic eye formation in a pathway conserved between flies and vertebrates

1997 • 296 citations

Hedgehog signaling is required for pituitary gland development

2001 • 290 citations

Inhibition of Sonic hedgehog signaling in vivo results in craniofacial neural crest cell death

1999 • 289 citations

Cell lineage of the imaginal discs in Drosophila gynandromorphs

1969 • 263 citations

A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord

2002 • 257 citations

Ectopic eye development in Drosophila induced by directed dachshund expression

1997 • 253 citations

cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in drosophila imaginal discs

1995 • 236 citations

wingless inhibits morphogenetic furrow movement in the Drosophila eye disc

1995 • 229 citations

Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye

1996 • 223 citations

Progression of the morphogenetic furrow in the Drosophila eye: the roles of Hedgehog, Decapentaplegic and the Raf pathway

1999 • 207 citations

Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development

2002 • 184 citations

Morphogenetic furrow initiation and progression during eye development in Drosophila: the roles of decapentaplegic, hedgehog and eyes absent

2000 • 175 citations

In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex

1998 • 173 citations

Regulatory Principles of Developmental Signaling

2002 • 155 citations

Sonic Hedgehog Opposes Epithelial Cell Cycle Arrest

1999 • 154 citations

Role of decapentaplegic in initiation and progression of the morphogenetic furrow in the developing Drosophila retina

1997 • 147 citations

The decapentaplegic gene: a TGF-β homologue controlling pattern formation in Drosophila

1989 • 144 citations

Signaling by the TGF-β homolog decapentaplegic functions reiteratively within the network of genes controlling retinal cell fate determination in Drosophila

1999 • 138 citations

senseless Repression of rough Is Required for R8 Photoreceptor Differentiation in the Developing Drosophila Eye

2001 • 128 citations

Sonic hedgehog promotes the survival of specific CNS neuron populations and protects these cells from toxic insult In vitro.

1997 • 122 citations

Dual role for Hedgehog in the regulation of the proneural gene atonal during ommatidia development

1999 • 120 citations

Regulation of furrow progression in the Drosophila eye by cAMP-dependent protein kinase A

1995 • 117 citations

Sonic Hedgehog Promotes the Survival of Specific CNS Neuron Populations and Protects These Cells from Toxic InsultIn Vitro

1997 • 112 citations

Mammalian homologues of the Drosophila eye specification genes

2001 • 109 citations

Mutual Regulation ofdecapentaplegicandhedgehogduring the Initiation of Differentiation in theDrosophilaRetina

1998 • 99 citations

The role of Wingless signaling in establishing the anteroposterior and dorsoventral axes of the eye disc

2001 • 89 citations

Hedgehog-Dependent Patterning in theDrosophilaEye Can Occur in the Absence of Dpp Signaling

1996 • 73 citations

Role of the morphogenetic furrow in establishing polarity in the Drosophila eye

1995 • 49 citations

hedgehog and wing development in Drosophila: a morphogen at work?

2000 • 46 citations

Retinal morphogenesis inDrosophila: Hints from an eye-specificdecapentaplegic allele

1997 • 26 citations