Regulation of Integrin-mediated p130Cas Tyrosine Phosphorylation in Human B Cells

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Adhesion receptors of the immune system

1990 • 6,585 citations

Integrins: Emerging Paradigms of Signal Transduction

1995 • 1,591 citations

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

1992 • 1,456 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

SRα Promoter: an Efficient and Versatile Mammalian cDNA Expression System Composed of the Simian Virus 40 Early Promoter and the R-U5 Segment of Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat

1988 • 1,351 citations

Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets.

1992 • 669 citations

A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner.

1994 • 653 citations

SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat.

1988 • 638 citations

Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas.

1995 • 423 citations

Induction of p130^cas Signaling Complex Formation upon Integrin-Mediated Cell Adhesion: a Role for Src Family Kinases

1996 • 422 citations

Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions.

1993 • 408 citations

C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.

1994 • 391 citations

Cloning and Characterization of Cell Adhesion Kinase β, a Novel Protein-tyrosine Kinase of the Focal Adhesion Kinase Subfamily

1995 • 385 citations

Identification and Characterization of a Novel Related Adhesion Focal Tyrosine Kinase (RAFTK) from Megakaryocytes and Brain

1995 • 365 citations

p130Cas, a Substrate Associated with v-Src and v-Crk, Localizes to Focal Adhesions and Binds to Focal Adhesion Kinase

1996 • 364 citations

Integrin-mediated Cell Adhesion Promotes Tyrosine Phosphorylation of p130Cas, a Src Homology 3-containing Molecule Having Multiple Src Homology 2-binding Motifs

1995 • 340 citations

The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions.

1995 • 329 citations

Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor.

1993 • 319 citations

Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells.

1994 • 314 citations

Adhesion of Human B Cells to Germinal Centers in Vitro Involves VLA-4 and INCAM-110

1990 • 295 citations

Adhesion of human B cells to follicular dendritic cells involves both the lymphocyte function-associated antigen 1/intercellular adhesion molecule 1 and very late antigen 4/vascular cell adhesion molecule 1 pathways.

1991 • 291 citations

Tyrosine Phosphorylation of p130Cas and Cortactin Accompanies Integrin-mediated Cell Adhesion to Extracellular Matrix

1995 • 289 citations

Direct Binding of the Proline-rich Region of Protein Tyrosine Phosphatase 1B to the Src Homology 3 Domain of p130Cas

1996 • 272 citations

Identification of p130^cas as a Substrate for the Cytosolic Protein Tyrosine Phosphatase PTP-PEST

1996 • 263 citations

Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin.

1996 • 235 citations

Vascular cell adhesion molecule-1 and the integrin VLA-4 mediate adhesion of human B cell precursors to cultured bone marrow adherent cells.

1991 • 234 citations

Human Enhancer of Filamentation 1, a Novel p130^cas-Like Docking Protein, Associates with Focal Adhesion Kinase and Induces Pseudohyphal Growth in Saccharomyces cerevisiae

1996 • 233 citations

Direct Binding of C-terminal Region of p130 to SH2 and SH3 Domains of Src Kinase

1996 • 229 citations

The SH2 and SH3 domains of pp60src direct stable association with tyrosine phosphorylated proteins p130 and p110.

1991 • 224 citations

Adhesion-induced tyrosine phosphorylation of the p130 SRC substrate

1995 • 223 citations

The Related Adhesion Focal Tyrosine Kinase Is Tyrosine-phosphorylated after β1-Integrin Stimulation in B Cells and Binds to p130cas

1997 • 214 citations

Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk

1994 • 211 citations

Adhesive ligand binding to integrin alpha IIb beta 3 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAK

1993 • 192 citations

The SH3 Domain-binding T Cell Tyrosyl Phosphoprotein p120

1995 • 186 citations

CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells.

1994 • 182 citations

Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes.

1996 • 165 citations

Signaling by integrins: implications for tumorigenesis.

1993 • 150 citations

Src Kinase Plays an Essential Role in Integrin-Mediated Tyrosine Phosphorylation of Crk-Associated Substrate p130Cas

1996 • 124 citations

Sos, Vav, and C3G Participate in B Cell Receptor-induced Signaling Pathways and Differentially Associate with Shc-Grb2, Crk, and Crk-L Adaptors

1996 • 118 citations

Involvement of p130Cas and p105HEF1, a Novel Cas-like Docking Protein, in a Cytoskeleton-dependent Signaling Pathway Initiated by Ligation of Integrin or Antigen Receptor on Human B Cells

1997 • 117 citations

p130CAS Forms a Signaling Complex with the Adapter Protein CRKL in Hematopoietic Cells Transformed by the BCR/ABL Oncogene

1996 • 114 citations

Molecular cloning of a cDNA encoding a phosphoprotein, Efs, which contains a Src homology 3 domain and associates with Fyn.

1995 • 111 citations

Tyrosine phosphorylation of pp125FAK by the aggregation of high affinity immunoglobulin E receptors requires cell adherence.

1993 • 110 citations

Cellular proteins binding to the first Src homology 3 (SH3) domain of the proto-oncogene product c-Crk indicate Crk-specific signaling pathways.

1995 • 100 citations

The identification of p130cas-binding proteins and their role in cellular transformation.

1996 • 98 citations

Adhesion through the Interaction of Lymphocyte Function-associated Antigen-1 with Intracellular Adhesion Molecule-1 Induces Tyrosine Phosphorylation of p130 and Its Association with c-CrkII

1996 • 81 citations

Inhibition of human bone marrow lymphoid progenitor colonies by antibodies to VLA integrins.

1992 • 58 citations

Maturation-dependent adhesion of human B cell precursors to the bone marrow microenvironment.

1990 • 47 citations

Biochemical analysis of p120/130: a protein-tyrosine kinase substrate restricted to T and myeloid cells.

1997 • 45 citations

Stimulation of tyrosine phosphorylation after ligation of beta7 and beta1 integrins on human B cells

1996 • 37 citations

Tyrosine phosphorylation of the product of the c-cbl protooncogene is [corrected] induced after integrin stimulation.

1997 • 29 citations

Identification of amino acids at the junction of exons 3 and 7 that are used for the generation of glycosylation-related human CD45RO and CD45RO-like antigen specificities.

1994 • 15 citations