Relationship of tobacco/alcohol use to p53 expression in patients with lingual squamous cell carcinomas

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

1988 • 1,140 citations

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1982 • 883 citations

p53: oncogene or anti-oncogene?

1990 • 812 citations

P53 expression in breast cancer

1988 • 612 citations

Smoking and drinking in relation to cancers of the oral cavity, pharynx, larynx, and esophagus in northern Italy.

1990 • 589 citations

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group.

1990 • 515 citations

Isolation of human‐p53‐specific monoclonal antibodies and their use in the studies of human p53 expression

1986 • 508 citations

Monoclonal antibodies provide specific intramolecular markers for the study of epithelial tonofilament organization.

1982 • 477 citations

Frequent mutation of the p53 gene in human esophageal cancer.

1990 • 393 citations

Comparative epidemiology of tobacco-related cancers.

1977 • 319 citations

Frequent p53 mutations in head and neck cancer.

1992 • 287 citations

p53 Mutations in non-small cell lung cancer in Japan: Association between mutations and smoking

1992 • 280 citations

HUMAN TUMOR SUPPRESSOR GENES

1990 • 266 citations

Elevated P53 expression correlates with a history of heavy smoking in squamous cell carcinoma of the head and neck

1991 • 259 citations

Most human squamous cell carcinomas in the oral cavity contain mutated p53 tumor-suppressor genes.

1992 • 237 citations

Expression of p53 in premalignant and malignant squamous epithelium.

1991 • 237 citations

Constant denaturant gel electrophoresis as a rapid screening technique for p53 mutations.

1991 • 192 citations

Assessment of p53 protein expression in normal, benign, and malignant oral mucosa

1992 • 187 citations

Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53.

1985 • 174 citations

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer

1991 • 173 citations

p53 interacts with p34cdc2 in mammalian cells: implications for cell cycle control and oncogenesis.

1990 • 156 citations

Etiological and preventive implications in alcohol carcinogenesis.

1979 • 134 citations

Identification of intronic point mutations as an alternative mechanism for p53 inactivation in lung cancer.

1990 • 127 citations

Expression of p53 mutant nuclear phosphoprotein in oral carcinoma and potentially malignant oral lesions

1992 • 117 citations

Regulation of the level of the oncoprotein p53 in non-transformed and transformed cells.

1990 • 109 citations

p53 protein in odontogenic cysts: increased expression in some odontogenic keratocysts.

1992 • 98 citations

Human Papillomavirus DNA in Biopsies of Oral Tissues

1991 • 90 citations

Association of casein kinase II with immunopurified p53.

1991 • 86 citations

Detection of p53 in primary lung tumors and nonsmall cell lung carcinoma cell lines.

1991 • 78 citations

p53 protein expression in central nervous system neoplasms.

1992 • 59 citations