Human Cytomegalovirus Envelope Glycoproteins B and H Are Necessary for TLR2 Activation in Permissive Cells

Pathogen Recognition and Innate Immunity

2006 • 11,197 citations

Toll-like receptor signalling

2004 • 7,983 citations

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1998 • 7,541 citations

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

Toll-Like Receptors

2003 • 6,127 citations

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8

2004 • 3,766 citations

Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA

2004 • 3,325 citations

Recognition of single-stranded RNA viruses by Toll-like receptor 7

2004 • 1,777 citations

Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2

1999 • 1,714 citations

Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

2000 • 1,644 citations

Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 (Tlr4)

1999 • 1,570 citations

Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

2001 • 1,498 citations

Integrin signalling during tumour progression

2004 • 1,430 citations

TLR9 signals after translocating from the ER to CpG DNA in the lysosome

2004 • 1,326 citations

Cutting Edge: Recognition of Gram-Positive Bacterial Cell Wall Components by the Innate Immune System Occurs Via Toll-Like Receptor 2

1999 • 1,252 citations

Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells

2003 • 1,189 citations

Cutting Edge: Repurification of Lipopolysaccharide Eliminates Signaling Through Both Human and Murine Toll-Like Receptor 2

2000 • 1,173 citations

Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection

2004 • 946 citations

Toll-like Receptor 2 Functions as a Pattern Recognition Receptor for Diverse Bacterial Products

1999 • 939 citations

Leucine-rich repeats and pathogen recognition in Toll-like receptors

2003 • 741 citations

Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments

2002 • 724 citations

TLR9-Dependent Recognition of MCMV by IPC and DC Generates Coordinated Cytokine Responses that Activate Antiviral NK Cell Function

2004 • 719 citations

Lipopolysaccharide recognition: CD14, TLRs and the LPS-activation cluster

2002 • 715 citations

Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9

2003 • 690 citations

Human Cytomegalovirus Activates Inflammatory Cytokine Responses via CD14 and Toll-Like Receptor 2

2003 • 660 citations

Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis

2004 • 603 citations

Herpesvirus Entry: an Update

2003 • 570 citations

VIRUS-CELL AND CELL-CELL FUSION

1996 • 559 citations

Intracellular signalling controlling integrin activation in lymphocytes

2005 • 547 citations

Hemagglutinin Protein of Wild-Type Measles Virus Activates Toll-Like Receptor 2 Signaling

2002 • 498 citations

Cutting Edge: Functional Interactions Between Toll-Like Receptor (TLR) 2 and TLR1 or TLR6 in Response to Phenol-Soluble Modulin

2001 • 477 citations

Outcome of Symptomatic Congenital Cytomegalovirus Infection: Results of Long-Term Longitudinal Follow-up

1980 • 431 citations

Epidermal growth factor receptor is a cellular receptor for human cytomegalovirus

2003 • 418 citations

Ganciclovir

1990 • 399 citations

Murine retroviruses activate B cells via interaction with toll-like receptor 4

2002 • 388 citations

The immunobiology of the TLR9 subfamily

2004 • 339 citations

Cellular integrins function as entry receptors for human cytomegalovirus via a highly conserved disintegrin-like domain

2004 • 324 citations

Human cytomegalovirus productively infects primary differentiated macrophages

1991 • 314 citations

High prevalence of latently present cytomegalovirus in arterial walls of patients suffering from grade III atherosclerosis.

1990 • 310 citations

Innate Sensing of Viruses by Toll-Like Receptors

2004 • 257 citations

Human cytomegalovirus upregulates NF-kappa B activity by transactivating the NF-kappa B p105/p50 and p65 promoters

1995 • 253 citations

Integrin αvβ3 is a coreceptor for human cytomegalovirus

2005 • 253 citations

Foscarnet

1991 • 250 citations

Ligand-regulated Chimeric Receptor Approach Reveals Distinctive Subcellular Localization and Signaling Properties of the Toll-like Receptors

2004 • 235 citations

Human cytomegalovirus penetrates host cells by PH-independent fusion at the cell surface

1992 • 222 citations

The pH independence of mammalian retrovirus infection

1990 • 210 citations

Global modulation of cellular transcription by human cytomegalovirus is initiated by viral glycoprotein B

2001 • 206 citations

The human cytomegalovirus UL55 (gB) and UL75 (gH) glycoprotein ligands initiate the rapid activation of Sp1 and NF-kappaB during infection

1997 • 202 citations

Engagement of the Cellular Receptor for Glycoprotein B of Human Cytomegalovirus Activates the Interferon-Responsive Pathway

1999 • 200 citations

The interferon in TLR signaling: more than just antiviral

2003 • 195 citations

Neutralizing antibodies detect a disulfide-linked glycoprotein complex within the envelope of human cytomegalovirus

1984 • 195 citations

Cytomegalovirus DNA in arterial walls of patients with atherosclerosis

1994 • 189 citations

Human Cytomegalovirus Binding to Human Monocytes Induces Immunoregulatory Gene Expression

1999 • 180 citations

Human Cytomegalovirus Replicates Abortively in Polymorphonuclear Leukocytes after Transfer from Infected Endothelial Cells via Transient Microfusion Events

2000 • 171 citations

Varicella-Zoster Virus Activates Inflammatory Cytokines in Human Monocytes and Macrophages via Toll-Like Receptor 2

2005 • 170 citations

Toll-Like Receptors Confer Responsiveness to Lipopolysaccharide fromPorphyromonas gingivalisin Human Gingival Fibroblasts

2000 • 153 citations

Induction of the transcription factor Sp1 during human cytomegalovirus infection mediates upregulation of the p65 and p105/p50 NF-kappaB promoters

1997 • 141 citations

Subversion of the innate immune system by a retrovirus

2003 • 141 citations

Do Pathogens Accelerate Atherosclerosis?

2001 • 139 citations

Herpesvirus infections in transplant recipients: current challenges in the clinical management of cytomegalovirus and Epstein-Barr virus infections.

2003 • 125 citations

Identification of a neutralizing epitope on glycoprotein gp58 of human cytomegalovirus

1989 • 119 citations

Tropism of human cytomegalovirus for endothelial cells is determined by a post-entry step dependent on efficient translocation to the nucleus

2000 • 116 citations

Human Cytomegalovirus Elicits a Coordinated Cellular Antiviral Response via Envelope Glycoprotein B

2004 • 116 citations

Receptor-Binding Properties of a Soluble Form of Human Cytomegalovirus Glycoprotein B

1998 • 115 citations

Glycoprotein H of human cytomegalovirus is a major antigen for the neutralizing humoral immune response

1996 • 115 citations

Latency and Reactivation of Human Cytomegalovirus

2002 • 111 citations

Contrasting responses of human gingival and periodontal ligament fibroblasts to bacterial cell‐surface components through the CD14/Toll‐like receptor system

2003 • 109 citations

Human Cytomegalovirus Latency and Reactivation – A Delicate Balance between the Virus and Its Host’s Immune System

1999 • 104 citations

Characterization of Human Cytomegalovirus Glycoprotein-Induced Cell-Cell Fusion

2005 • 98 citations

Bacterial fimbriae activate human peripheral blood monocytes utilizing TLR2, CD14 and CD11a/CD18 as cellular receptors

2002 • 94 citations

Anti-idiotype antibodies that mimic gp86 of human cytomegalovirus inhibit viral fusion but not attachment

1991 • 91 citations

Coiled-Coil Domains in Glycoproteins B and H Are Involved in Human Cytomegalovirus Membrane Fusion

2004 • 83 citations

Outcome of confirmed symptomatic congenital cytomegalovirus infection.

1991 • 79 citations

Cytoplasmic Domain-mediated Dimerizations of Toll-like Receptor 4 Observed by β-Lactamase Enzyme Fragment Complementation

2004 • 78 citations

Characterization of a novel third member of the human cytomegalovirus glycoprotein H-glycoprotein L complex

1997 • 73 citations

Function of Human Cytomegalovirus Glycoprotein B: Syncytium Formation in Cells Constitutively Expressing gB Is Blocked by Virus-Neutralizing Antibodies

1994 • 71 citations

Structural Domains Involved in Human Cytomegalovirus Glycoprotein B-Mediated Cell-cell Fusion

1996 • 63 citations

An immortalized human fibroblast cell line is permissive for human cytomegalovirus infection

1993 • 61 citations

Cytomegalovirus and atherosclerosis

1995 • 56 citations

Cytomegalovirus infections in transplant patients.

1996 • 50 citations

Distinct Glycoprotein O Complexes Arise in a Post-Golgi Compartment of Cytomegalovirus-Infected Cells

2002 • 35 citations

Expression and reconstitution of the gH/gL/gO complex of human cytomegalovirus

2002 • 25 citations

Processing of human cytomegalovirus envelope glycoproteins in and egress of cytomegalovirus from human astrocytoma cells

1992 • 23 citations

Characterization of the Signal Peptide Processing and Membrane Association of Human Cytomegalovirus Glycoprotein O

2001 • 18 citations