What is the rationale for hydrocortisone treatment in children with infection-related adrenal insufficiency and septic shock?

Effect of Treatment With Low Doses of Hydrocortisone and Fludrocortisone on Mortality in Patients With Septic Shock

2002 • 3,043 citations

A Controlled Clinical Trial of High-Dose Methylprednisolone in the Treatment of Severe Sepsis and Septic Shock

1987 • 1,434 citations

A 3-Level Prognostic Classification in Septic Shock Based on Cortisol Levels and Cortisol Response to Corticotropin

2000 • 997 citations

The Effects of High-Dose Corticosteroids in Patients with Septic Shock

1984 • 761 citations

Effect of High-Dose Glucocorticoid Therapy on Mortality in Patients with Clinical Signs of Systemic Sepsis

1987 • 687 citations

Corticosteroid treatment for sepsis

1995 • 627 citations

Inhibition of Adrenal Steroidogenesis by the Anesthetic Etomidate

1984 • 529 citations

Steroid controversy in sepsis and septic shock

1995 • 484 citations

CLINICAL APPLICATION OF A NEW TEST OF PITUITARY RESERVE*

1959 • 459 citations

Postnatal Corticosteroids to Treat or Prevent Chronic Lung Disease in Preterm Infants

2002 • 431 citations

On the constitutional and local effects of disease of the supra-renal capsules

1855 • 423 citations

The Physiological Effects of Extracts of the Suprarenal Capsules

1895 • 356 citations

Adrenal insufficiency occurring during septic shock: incidence, outcome, and relationship to peripheral cytokine levels

1995 • 279 citations

Etomidate Inhibits Adrenocortical Function in Surgical Patients

1984 • 221 citations

A Double-Blind, Randomized, Controlled Study of a “Stress Dose” of Hydrocortisone for Rescue Treatment of Refractory Hypotension in Preterm Infants

2006 • 215 citations

A CASE OF SUPRARENAL APOPLEXY.

1911 • 213 citations

Adrenocortical Hormones in Infection and Immunity

1953 • 206 citations

Structural and Functional Brain Development After Hydrocortisone Treatment for Neonatal Chronic Lung Disease

2005 • 195 citations

Plasma cortisol levels in patients with septic shock

1990 • 193 citations

Absolute and relative adrenal insufficiency in children with septic shock*

2005 • 193 citations

Adrenal Insufficiency in Meningococcal Sepsis: Bioavailable Cortisol Levels and Impact of Interleukin-6 Levels and Intubation with Etomidate on Adrenal Function and Mortality

2005 • 180 citations

Adrenocortical function during septic shock

1995 • 166 citations

Adrenal insufficiency in septic shock

1999 • 160 citations

A comparison of the adrenocortical response during septic shock and after complete recovery

1996 • 154 citations

Low-dose hydrocortisone infusion attenuates the systemic inflammatory response syndrome

1994 • 153 citations

Endocrine and Metabolic Responses in Children with Meningoccocal Sepsis: Striking Differences between Survivors and Nonsurvivors

2000 • 136 citations

A retrospective cohort study of prognostic factors associated with outcome in pediatric severe sepsis: What is the role of steroids?*

2005 • 111 citations

A PRELIMINARY REPORT ON THE ACTIVE PRINCIPLE OF THE SUPRARENAL GLAND

1901 • 102 citations

Admission cortisol and adrenocorticotrophic hormone levels in children with meningococcal disease: Evidence of adrenal insufficiency?

1999 • 101 citations

Physiological Approach to Successful Treatment of Endotoxin Shock in the Experimental Animal

1959 • 88 citations

Clinical Trial Design in Studies of Corticosteroids for Bacterial Infections

1974 • 86 citations

Low serum cortisol in combination with high adrenocorticotrophic hormone concentrations are associated with poor outcome in children with severe meningococcal disease

2002 • 83 citations

Corticosteroids and infections.

1958 • 79 citations

Etomidate for emergency anaesthesia; mad, bad and dangerous to know?

2005 • 79 citations

Adrenal functions in patients with sepsis^*

2009 • 69 citations

Hydrocortisone in the management of dengue shock syndrome.

1975 • 67 citations

Combined Stimulation of Adrenocorticotropin and Compound-S by Single Dose Metyrapone Test as an Outpatient Procedure to Assess Hypothalamic-Pituitary-Adrenal Function

2002 • 63 citations

Acute Adrenal Insufficiency presenting as Shock After Trauma and Surgery

1992 • 62 citations

Adrenocortical Hormones and the Management of Infection

1957 • 53 citations

Clinical Impact of Corticosteroid-Induced Adrenal Suppression during Treatment for Acute Lymphoblastic Leukemia in Children: A Prospective Observational Study Using the Low-Dose Adrenocorticotropin Test

2005 • 52 citations

On the Constitutional and Local Effects of Disease of the Supra-renal Capsules

2009 • 50 citations

WATERHOUSE-FRIDERICHSEN SYNDROME (W.-F. S.)

1955 • 49 citations

The Effects of High-Dose Corticosteroids in Patients with Septic Shock, a Prospective, Controlled Study

1985 • 46 citations

Corticosteroid/antibiotic treatment of adrenalectomized dogs challenged with lethal E. coli.

1985 • 46 citations

Endocrine and Metabolic Responses in Children with Meningoccocal Sepsis: Striking Differences between Survivors and Nonsurvivors

2000 • 42 citations

Serum Cortisol responses in febrile children

1989 • 39 citations

Adrenal Steroids and Resistance to Infection

2015 • 20 citations

Adrenal insufficiency in children with septic shock

2003 • 17 citations

A RETROSPECTIVE COHORT STUDY OF PROGNOSTIC FACTORS ASSOCIATED WITH OUTCOME IN PEDIATRIC SEVERE SEPSIS: WHAT IS THE ROLE OF STEROIDS?

2004 • 14 citations

Internal Secretions in Disease: The Historical Relations of Clinical Medicine and Scientific Physiology

1984 • 13 citations

A comparison of the adrenocortical response during septic shock and after complete recovery

1996 • 13 citations

Adrenal insufficiency in septic shock

2000 • 13 citations

Clinical application of a new test of “pituitary reserve”

1959 • 9 citations

Adrenocortical Insufficiency: A Medical Emergency

1992 • 9 citations

Corticosteroids for Patients With Septic Shock

2003 • 9 citations

Serum prolactin and cortisol in children with some paroxysmal disorders

1994 • 8 citations

AN AUTOGRAPH HISTORY OF A CASE OF ADDISON'S DISEASE

1921 • 7 citations

The American Hospital Formulary

1958 • 6 citations

SUBSEQUENT COURSE OF A CASE OF ADDISON'S DISEASE

1922 • 6 citations

Hormones and synthetic substitutes.

1968 • 4 citations

[Waterhouse-Friderichsen syndrome].

1956 • 4 citations

A Double-Blind, Randomized, Controlled Study of a “Stress Dose” of Hydrocortisone for Rescue Treatment of Refractory Hypotension in Preterm Infants

2007 • 2 citations

Adrenal failure in the critically ill

1998 • 2 citations