Systemic and local human papillomavirus 16‐specific T‐cell immunity in patients with head and neck cancer

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2011 • 55,498 citations

Global Cancer Statistics, 2002

2005 • 17,966 citations

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2010 • 1,740 citations

Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia

2009 • 1,027 citations

Prognostic Value of Tumor-Infiltrating CD4+ T-Cell Subpopulations in Head and Neck Cancers

2006 • 561 citations

Meta-analysis of the impact of human papillomavirus (HPV) on cancer risk and overall survival in head and neck squamous cell carcinomas (HNSCC)

2010 • 509 citations

Treatment of Vulvar Intraepithelial Neoplasia with Topical Imiquimod

2008 • 372 citations

Induction of Tumor-Specific CD4+ and CD8+ T-Cell Immunity in Cervical Cancer Patients by a Human Papillomavirus Type 16 E6 and E7 Long Peptides Vaccine

2008 • 360 citations

CD8+ Foxp3+ Regulatory T Cells Mediate Immunosuppression in Prostate Cancer

2007 • 348 citations

Human Papillomavirus Type 16-Positive Cervical Cancer Is Associated with Impaired CD4+ T-Cell Immunity against Early Antigens E2 and E6

2004 • 311 citations

Phase II trial of imiquimod and HPV therapeutic vaccination in patients with vulval intraepithelial neoplasia

2010 • 237 citations

Success or failure of vaccination for HPV16-positive vulvar lesions correlates with kinetics and phenotype of induced T-cell responses

2010 • 229 citations

Human Leukocyte Antigen Class I, MHC Class I Chain-Related Molecule A, and CD8+/Regulatory T-Cell Ratio: Which Variable Determines Survival of Cervical Cancer Patients?

2008 • 220 citations

Oropharyngeal Cancer Epidemic and Human Papillomavirus

2010 • 218 citations

Association of cervical cancer with the presence of CD4⁺regulatory T cells specific for human papillomavirus antigens

2007 • 215 citations

The Relationship Between Human Papillomavirus Status and Other Molecular Prognostic Markers in Head and Neck Squamous Cell Carcinomas

2009 • 210 citations

Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma

2009 • 198 citations

Induction of p53-Specific Immunity by a p53 Synthetic Long Peptide Vaccine in Patients Treated for Metastatic Colorectal Cancer

2009 • 168 citations

Increased Ectonucleotidase Expression and Activity in Regulatory T Cells of Patients with Head and Neck Cancer

2009 • 166 citations

Antitumor Activity of Human Papillomavirus Type 16 E7–Specific T Cells against Virally Infected Squamous Cell Carcinoma of the Head and Neck

2005 • 155 citations

Frequent detection of human papillomavirus 16 E2-specific T-helper immunity in healthy subjects.

2002 • 152 citations

Immunization with a P53 synthetic long peptide vaccine induces P53‐specific immune responses in ovarian cancer patients, a phase II trial

2009 • 139 citations

Tumor-infiltrating lymphocytes, particularly the balance between CD8+ T cells and CCR4+ regulatory T cells, affect the survival of patients with oral squamous cell carcinoma

2010 • 133 citations

Therapeutic vaccination against human papilloma virus induced malignancies

2011 • 120 citations

Immune responses to p53 in patients with cancer:enrichment in tetramer+ p53 peptide-specific T cells and regulatory T cells at tumor sites

2005 • 104 citations

Analysis of p53 Serum Antibodies in Patients With Head and Neck Squamous Cell Carcinoma

1996 • 102 citations

Frequencies of tetramer+ T cells specific for the wild-type sequence p53(264-272) peptide in the circulation of patients with head and neck cancer.

2002 • 97 citations

T cells specific for HPV16 E7 epitopes in patients with squamous cell carcinoma of the oropharynx

2005 • 90 citations

Human papilloma virus specific T cells infiltrating cervical cancer and draining lymph nodes show remarkably frequent use of HLA‐DQ and –DP as a restriction element

2007 • 82 citations

Unique Phenotype of Human Tonsillar and In Vitro-Induced FOXP3+CD8+ T Cells

2009 • 80 citations

An Unexpectedly Large Polyclonal Repertoire of HPV-Specific T Cells Is Poised for Action in Patients with Cervical Cancer

2010 • 78 citations

Spectral Clustering of Microarray Data Elucidates the Roles of Microenvironment Remodeling and Immune Responses in Survival of Head and Neck Squamous Cell Carcinoma

2010 • 75 citations

HPV16 semiquantitative viral load and serologic biomarkers in oral and oropharyngeal squamous cell carcinomas

2005 • 71 citations

Risk factors and survival by HPV‐16 E6 and E7 antibody status in human papillomavirus positive head and neck cancer

2009 • 62 citations

Immunotherapy of Head and Neck Cancer: Current and Future Considerations

2009 • 61 citations

Neoadjuvant Immunotherapy of Oral Squamous Cell Carcinoma Modulates Intratumoral CD4/CD8 Ratio and Tumor Microenvironment: A Multicenter Phase II Clinical Trial

2005 • 57 citations

Novel neoadjuvant immunotherapy regimen safety and survival in head and neck squamous cell cancer

2011 • 52 citations

Prognostic significance of serum p53 protein and p53 antibody in patients with surgical treatment for head and neck squamous cell carcinoma

2001 • 51 citations

The detection of circulating human papillomavirus‐specific T cells is associated with improved survival of patients with deeply infiltrating tumors

2010 • 50 citations

Immunological and Clinical Effects of Vaccines Targeting p53-Overexpressing Malignancies

2011 • 44 citations

Human papillomavirus in malignant cervical lesions in Surinam, a high-risk country, compared to the Netherlands, a low-risk country

1999 • 41 citations

Surgery followed by Persistence of High-Grade Squamous Intraepithelial Lesions Is Associated with the Induction of a Dysfunctional HPV16-Specific T-Cell Response

2008 • 40 citations

Magnitude and polarization of P53‐specific T‐helper immunity in connection to leukocyte infiltration of colorectal tumors

2003 • 28 citations

Influenza matrix 1‐specific human CD4⁺FOXP3⁺ and FOXP3⁻ regulatory T cells can be detected long after viral clearance

2010 • 20 citations