Neoadjuvant Immunotherapy of Oral Squamous Cell Carcinoma Modulates Intratumoral CD4/CD8 Ratio and Tumor Microenvironment: A Multicenter Phase II Clinical Trial

Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte–macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma

1998 • 586 citations

Spontaneous apoptosis of circulating T lymphocytes in patients with head and neck cancer and its clinical importance.

2002 • 375 citations

Vaccination With Irradiated, Autologous Melanoma Cells Engineered to Secrete Granulocyte-Macrophage Colony-Stimulating Factor by Adenoviral-Mediated Gene Transfer Augments Antitumor Immunity in Patients With Metastatic Melanoma

2003 • 306 citations

CD4+ T-Cell Immune Response to Large B-Cell Non-Hodgkin’s Lymphoma Predicts Patient Outcome

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Antigen-specific CD4+ T-cell help is required to activate a memory CD8+ T cell to a fully functional tumor killer cell.

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T-Cell Activation Marker Expression on Tumor-Infiltrating Lymphocytes As Prognostic Factor in Cutaneous Malignant Melanoma

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HLA-DR Antigen Expression in Primary Melanomas of the Skin

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Presence of the T-cell activation marker OX-40 on tumor infiltrating lymphocytes and draining lymph node cells from patients with melanoma and head and neck cancers

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Evidence for local and systemic activation of immune cells by peritumoral injections of interleukin 2 in patients with advanced squamous cell carcinoma of the head and neck.

1993 • 112 citations

Reversed CD4/CD8 ratios of tumor-infiltrating lymphocytes are correlated with the progression of human cervical carcinoma

1999 • 100 citations

Tumor escape mechanisms from immunosurveillance: induction of unresponsiveness in a specific MHC-restricted CD4⁺; human T cell clone by the autologous MHC class II⁺ melanoma

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Tumour-infiltrating lymphocytes in metastatic malignant melanoma and response to interferon alpha treatment

1996 • 89 citations

Effector CD8+CD45RO−CD27−T cells have signalling defects in patients with squamous cell carcinoma of the head and neck

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Improved survival with perilymphatic interleukin 2 in patients with resectable squamous cell carcinoma of the oral cavity and oropharynx

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Interleukins and Contrasuppression Induce Immune Regression of Head and Neck Cancer

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Interleukin-2 injected around tumor-draining lymph nodes in head and neck cancer

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The role of CD4+ tumor-infiltrating lymphocytes in human solid tumors

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Lymphocyte Subpopulations in Patients with Advanced Breast Cancer Submitted to Neoadjuvant Chemotherapy

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In vivo interleukin 2-induced activation of lymphokine-activated killer cells and tumor cytotoxic T-cells in cervical lymph nodes of patients with head and neck tumors.

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Phase Ib Trial of the Effect of Peritumoral and Intranodal Injections of Interleukin-2 in Patients with Advanced Squamous Cell Carcinoma of the Head and Neck: An Eastern Cooperative Oncology Group Trial

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Treatment of Oral Cavity and Oropharynx Squamous Cell Carcinoma with Perilymphatic Interleukin-2

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Impairment of T-Cell Activation in Head and Neck Cancer In Situ and In Vitro

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A trial of IRX-2 in patients with squamous cell carcinomas of the head and neck

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Immunobiology and immunotherapy of head and neck cancer

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Combination Immunotherapy of Squamous Cell Carcinoma of the Head and Neck

2000 • 32 citations

Histologic findings in patients with head and neck squamous cell carcinoma receiving perilymphatic natural cytokine mixture (IRX-2) prior to surgery.

1998 • 31 citations

Tumor-Infiltrating Lymphocytes Contain Higher Numbers of Type 1 Cytokine Expressors and DR+ T Cells Compared with Lymphocytes from Tumor Draining Lymph Nodes and Peripheral Blood in Patients with Cancer of the Uterine Cervix

2001 • 31 citations

Effect of Tumor-Infiltrating Lymphocyte Subsets on Prognosis and Susceptibility to Interferon Therapy in Patients with Renal Cell Carcinoma

2002 • 28 citations

A natural cytokine mixture (IRX-2) and interference with immune suppression induce immune mobilization and regression of head and neck cancer

1998 • 28 citations

Lack of MHC class I surface expression on neoplastic cells and poor activation of the secretory pathway of cytotoxic cells in oral squamous cell carcinomas

1999 • 26 citations

Infiltrating leukocyte populations and T-lymphocyte subsets in head and neck squamous cell carcinomas from patients receiving perilymphatic injections of recombinant interleukin 2. A pathologic and immunophenotypic study.

1990 • 20 citations

The Effect of Leukocyte Interleukin Injection (Multikine®) Treatment on the Peritumoral and Intratumoral Subpopulation of Mononuclear Cells and on Tumor Epithelia: A Possible New Approach to Augmenting Sensitivity to Radiation Therapy and Chemotherapy in Oral Cancer—A Multicenter Phase I/II Clinical Trial

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The phenotypic changes in tumour infiltrating lymphocytes and tumour cells following intra‐arterial infusion of interleukin‐2 in patients with squamous cell carcinoma

1995 • 15 citations

Immunology and growth characteristics of ocular basal cell carcinoma

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Molecular pathology of tumor metastasis III

2003 • 10 citations

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