Conditional Suppression of Cellular Genes: Lentivirus Vector-Mediated Drug-Inducible RNA Interference

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector

1996 • 4,854 citations

A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

2002 • 4,334 citations

Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors

2002 • 2,019 citations

Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo

1997 • 1,977 citations

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

2003 • 1,515 citations

Modulation of HIV-1 replication by RNA interference

2002 • 715 citations

Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5

2002 • 709 citations

Transduction of Human CD34 ⁺ Cells That Mediate Long-Term Engraftment of NOD/SCID Mice by HIV Vectors

1999 • 648 citations

Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors

1997 • 614 citations

Krüppel-associated boxes are potent transcriptional repression domains.

1994 • 612 citations

A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA

2003 • 547 citations

Transgenesis by lentiviral vectors: Lack of gene silencing in mammalian embryonic stem cells and preimplantation embryos

2002 • 529 citations

The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins.

1991 • 368 citations

Lentiviral-Mediated RNA Interference

2002 • 288 citations

Retroviral delivery of small interfering RNA into primary cells

2002 • 282 citations

Tetracycline-Reversible Silencing of Eukaryotic Promoters

1995 • 271 citations

Silencing of RNA Polymerases II and III-Dependent Transcription by the KRAB Protein Domain of KOX1, a Krüppel-Type Zinc Finger Factor

1997 • 84 citations

Regulatable systems: applications in gene therapy and replicating viruses

2000 • 79 citations

A variety of RNA polymerases II and III-dependent promoter classes is repressed by factors containing the Krüppel-associated/finger preceding box of zinc finger proteins

1999 • 22 citations