Lentiviral-Mediated RNA Interference

A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

2002 • 4,334 citations

RNA interference is mediated by 21- and 22-nucleotide RNAs

2001 • 3,271 citations

RNAi

2000 • 2,596 citations

Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors

2002 • 2,019 citations

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

2002 • 1,526 citations

Neurodegeneration Prevented by Lentiviral Vector Delivery of GDNF in Primate Models of Parkinson's Disease

2000 • 1,255 citations

A DNA vector-based RNAi technology to suppress gene expression in mammalian cells

2002 • 1,117 citations

RNA interference in adult mice

2002 • 1,060 citations

RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells

2002 • 1,037 citations

Self-Inactivating Lentiviral Vectors with Enhanced Transgene Expression as Potential Gene Transfer System in Parkinson's Disease

2000 • 293 citations

RNA interference in mammalian cells using siRNAs synthesized with T7 RNA polymerase

2002 • 275 citations

Lentiviral-Mediated Delivery of Mutant Huntingtin in the Striatum of Rats Induces a Selective Neuropathology Modulated by Polyglutamine Repeat Size, Huntingtin Expression Levels, and Protein Length

2002 • 215 citations

Lentiviral Vector-Mediated Delivery of Short Hairpin RNA Results in Persistent Knockdown of Gene Expression in Mouse Brain

2003 • 119 citations

In vivo knockdown of gene expression in brain cancer with intravenous RNAi in adult rats

2003 • 114 citations

The utility of siRNA transcripts produced by RNA polymerase i in down regulating viral gene expression and replication of negative- and positive-strand RNA viruses

2003 • 82 citations

RNA interference and human disease

2003 • 82 citations

RNA interference: on the road to an alternate therapeutic strategy!

2003 • 78 citations

Gene silencing in mammalian cells by PCR‐based short hairpin RNA

2003 • 53 citations

Inhibition of GM-CSF Receptor Function by Stable RNA Interference in a NOD/SCID Mouse Hematopoietic Stem Cell Transplantation Model

2003 • 33 citations

RNA‐Interference‐Based Silencing of Mammalian Gene Expression

2003 • 10 citations

Recent Applications of RNA Interference (RNAi) in Mammalian Systems

2007 • 5 citations