Glucose Down-regulates the Expression of the Peroxisome Proliferator-activated Receptor-α Gene in the Pancreatic β-Cell

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism*

1999 • 2,880 citations

Fatty acid-induced β cell apoptosis: A link between obesity and diabetes

1998 • 1,142 citations

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.

1992 • 1,128 citations

Lipotoxicity in the Pathogenesis of Obesity-Dependent NIDDM: Genetic and Clinical Implications

1995 • 1,026 citations

The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene.

1992 • 903 citations

Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion.

2000 • 895 citations

IPF1, a homeodomain-containing transactivator of the insulin gene.

1993 • 882 citations

Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and β-pancreatic islet cells

1988 • 786 citations

Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion

1987 • 773 citations

The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP

2000 • 770 citations

What if Minkowski Had Been Ageusic? An Alternative Angle on Diabetes

1992 • 664 citations

Direct antidiabetic effect of leptin through triglyceride depletion of tissues

1997 • 664 citations

PPARγ, the ultimate thrifty gene

1999 • 609 citations

Fatty acids, lipotoxicity and insulin secretion

1999 • 563 citations

Chronic Hyperglycemia Triggers Loss of Pancreatic β Cell Differentiation in an Animal Model of Diabetes

1999 • 551 citations

An improved and simplified radioisotopic assay for the determination of free and esterified carnitine

1976 • 536 citations

Are the β-Cell Signaling Molecules Malonyl-CoA and Cystolic Long-Chain Acyl-CoA Implicated in Multiple Tissue Defects of Obesity and NIDDM?

1996 • 466 citations

Fatty Acids Activate Transcription of the Muscle Carnitine Palmitoyltransferase I Gene in Cardiac Myocytes via the Peroxisome Proliferator-activated Receptor α

1998 • 451 citations

Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion.

1992 • 440 citations

Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism.

2000 • 423 citations

Metabolic Fate of Glucose in Purified Islet Cells

1997 • 421 citations

Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells

1999 • 405 citations

Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy

1996 • 321 citations

REGULATION OF THE EXPRESSION OF LIPOGENIC ENZYME GENES BY CARBOHYDRATE

1997 • 294 citations

Fatty Acids Decrease IDX-1 Expression in Rat Pancreatic Islets and Reduce GLUT2, Glucokinase, Insulin, and Somatostatin Levels

1997 • 286 citations

Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.

1998 • 256 citations

Troglitazone Lowers Islet Fat and Restores Beta Cell Function of Zucker Diabetic Fatty Rats

1998 • 252 citations

Troglitazone prevents mitochondrial alterations, β cell destruction, and diabetes in obese prediabetic rats

1999 • 238 citations

REPRODUCIBLE HIGH YIELD OF RAT ISLETS BY STATIONARY IN VITRO DIGESTION FOLLOWING PANCREATIC DUCTAL OR PORTAL VENOUS COLLAGENASE INJECTION1

1987 • 220 citations

Mechanisms of inhibition of insulin release

1996 • 199 citations

New insights into pancreatic β-cell metabolic signaling in insulin secretion

1996 • 197 citations

Glucose stimulation of lipogenic enzyme gene expression in cultured white adipose tissue. A role for glucose 6-phosphate.

1992 • 184 citations

Increased Lipogenic Capacity of the Islets of Obese Rats: A Role in the Pathogenesis of NIDDM

1997 • 180 citations

Role of peroxisome proliferator-activated receptor α in disease of pancreatic β cells

1998 • 178 citations

Regulation of insulin gene expression by glucose and calcium in transfected primary islet cultures.

1990 • 174 citations

The reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression.

1995 • 149 citations

Long-term exposure of beta-INS cells to high glucose concentrations increases anaplerosis, lipogenesis, and lipogenic gene expression.

1998 • 147 citations

Fatty Acids Rapidly Induce the Carnitine Palmitoyltransferase I Gene in the Pancreatic β-Cell Line INS-1

1997 • 142 citations

Transcriptional Glucose Signaling through The Glucose Response Element Is Mediated by the Pentose Phosphate Pathway

1996 • 142 citations

Palmitate and oleate induce the immediate-early response genes c-fos and nur-77 in the pancreatic beta-cell line INS-1.

1999 • 142 citations

Induction by Glucose of Genes Coding for Glycolytic Enzymes in a Pancreatic β-Cell Line (INS-1)

1997 • 135 citations

Genetic, metabolic and clinical characteristics of maturity onset diabetes of the young

1998 • 131 citations

Glucose and glucoincretin peptides synergize to induce c-fos, c-jun, junB, zif-268, and nur-77 gene expression in pancreatic beta(INS-1) cells.

1998 • 130 citations

Glucose regulates acetyl-CoA carboxylase gene expression in a pancreatic beta-cell line (INS-1).

1993 • 128 citations

The pyruvate kinase gene as a model for studies of glucose-dependent regulation of gene expression in the endocrine pancreatic beta-cell type.

1993 • 126 citations

Caloric restriction in obese pre-diabetic rats prevents beta-cell depletion, loss of beta-cell GLUT 2 and glucose incompetence

1995 • 107 citations

Long-Chain Fatty Acids Inhibit Acetyl-CoA Carboxylase Gene Expression in the Pancreatic β-Cell Line INS-1

1997 • 101 citations

Glucose and glucoincretin peptides synergize to induce c‐fos, c‐jun,junB,zif‐268, and nur‐77gene expression in pancreatic β(INS‐1) cells

1998 • 97 citations

Glucose regulation of gene expression

1998 • 53 citations

Essentiality of intron control in the induction of c‐fosby glucose and glucoincretin peptides in INS‐1 β‐cells

2000 • 38 citations

The inhibitory effect of glucose on phosphoenolpyruvate carboxykinase gene expression in cultured hepatocytes is transcriptional and requires glucose metabolism

1999 • 36 citations

Pancreatic-specific expression of the glucose transporter type 2 gene: identification of cis-elements and islet-specific trans-acting factors.

1995 • 35 citations

Species differences in induction of hepatic enzymes by BM 17.0744, an activator of peroxisome proliferator-activated receptor alpha (PPARα)

1999 • 29 citations