Longchain n−3 polyunsaturated fatty acids and blood vessel function

Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial

1999 • 3,818 citations

EICOSAPENTAENOIC ACID AND PREVENTION OF THROMBOSIS AND ATHEROSCLEROSIS?

1978 • 1,689 citations

The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function

1984 • 1,616 citations

Fatty acid modulation of endothelial activation

2000 • 486 citations

Prostaglandin I3 is formed in vivo in man after dietary eicosapentaenoic acid

1984 • 476 citations

Docosahexaenoic Acid but Not Eicosapentaenoic Acid Lowers Ambulatory Blood Pressure and Heart Rate in Humans

1999 • 409 citations

Prevention of Sudden Cardiac Death by Dietary Pure ω-3 Polyunsaturated Fatty Acids in Dogs

1999 • 404 citations

Suppression of voltage-gated L-type Ca ²⁺ currents by polyunsaturated fatty acids in adult and neonatal rat ventricular myocytes

1997 • 384 citations

Dietary supplementation with marine omega-3 fatty acids improve systemic large artery endothelial function in subjects with hypercholesterolemia

2000 • 378 citations

Differential Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Vascular Reactivity of the Forearm Microcirculation in Hyperlipidemic, Overweight Men

2000 • 361 citations

Prostaglandin biosynthesis can be triggered by lipid peroxides

1979 • 357 citations

Dietary fish oil prevents ventricular fibrillation following coronary artery occlusion and reperfusion

1988 • 334 citations

Fish oil and cardiovascular disease: lipids and arterial function

2000 • 267 citations

Effect of fish oil on heart rate variability in survivors of myocardial infarction: a double blind randomised controlled trial

1996 • 250 citations

Prevention of fatal cardiac arrhythmias by polyunsaturated fatty acids

2000 • 239 citations

The cardiovascular protective role of docosahexaenoic acid

1996 • 198 citations

Heart rate variability and fatty acid content of blood cell membranes: a dose-response study with n−3 fatty acids

1999 • 195 citations

n−3 Fatty acids and the prevention of coronary atherosclerosis

2000 • 190 citations

Docosahexaenoic Acid Selectively Attenuates Induction of Vascular Cell Adhesion Molecule–1 and Subsequent Monocytic Cell Adhesion to Human Endothelial Cells Stimulated by Tumor Necrosis Factor–α

1995 • 187 citations

Effects of eicosapentaenoic acid and docosahexaenoic acid on plasma membrane fluidity of aortic endothelial cells

1999 • 187 citations

Fish Consumption, n-3 Fatty Acids in Cell Membranes, and Heart Rate Variability in Survivors of Myocardial Infarction With Left Ventricular Dysfunction

1997 • 184 citations

Fatty acids suppress voltage-gated Na ⁺ currents in HEK293t cells transfected with the α-subunit of the human cardiac Na ⁺ channel

1998 • 182 citations

Docosahexaenoic Acid, a Peroxisome Proliferator–Activated Receptor-α Ligand, Induces Apoptosis in Vascular Smooth Muscle Cells by Stimulation of p38 Mitogen-Activated Protein Kinase

2000 • 172 citations

Oxidative stress and cardiovascular complications in diabetes: isoprostanes as new markers on an old paradigm

2000 • 171 citations

Long-chain omega 3 fatty acids, blood lipids and cardiovascular risk reduction

2001 • 164 citations

Endothelial function as a determinant of vascular function and structure: A new therapeutic target

1997 • 160 citations

Control of endothelial leukocyte adhesion molecules by fatty acids

1996 • 158 citations

Eicosapentaenoic acid (EPA) induces Ca²⁺‐independent activation and translocation of endothelial nitric oxide synthase and endothelium‐dependent vasorelaxation

2001 • 157 citations

Eicosapentaenoic Acid Enhances Nitric Oxide Production by Cultured Human Endothelial Cells

1997 • 145 citations

Vascular prostacyclin is increased in patients ingesting omega-3 polyunsaturated fatty acids before coronary artery bypass graft surgery.

1990 • 141 citations

n-3 fatty acids and urinary excretion of nitric oxide metabolites in humans

1997 • 136 citations

Antioxidants and the bioactivity of endothelium-derived nitric oxide

2000 • 134 citations

Oxidants, nitric oxide and prostanoids in the developing ocular vasculature: a basis for ischemic retinopathy

2000 • 129 citations

THE ISOPROSTANES: UNIQUE PROSTAGLANDIN-LIKE PRODUCTS OF FREE-RADICAL-INITIATED LIPID PEROXIDATION*

1999 • 121 citations

Effect of ω3 fatty acids on oxidative stress in humans: GC–MS measurement of urinary F₂-isoprostane excretion

2000 • 116 citations

Inhibition of cardiac sodium currents in adult rat myocytes by n‐3 polyunsaturated fatty acids

1999 • 115 citations

Structural requirements for inhibition of cytokine-induced endothelial activation by unsaturated fatty acids

1998 • 110 citations

Partitioning of polyunsaturated fatty acids, which prevent cardiac arrhythmias, into phospholipid cell membranes

2001 • 99 citations

Dietary docosahexaenoic acid is retroconverted in man to eicosapentaenoic acid, which can be quickly transformed to prostaglandin I3

1987 • 86 citations

n-3 Polyunsaturated fatty acids and the cardiovascular system

2000 • 79 citations

Eicosapentaenoic acid and docosahexaenoic acid are antagonists at the thromboxane A₂/prostaglandin H₂ receptor in human platelets

1989 • 78 citations

HOW DO FISH OILS AFFECT VASCULAR FUNCTION?

1995 • 77 citations

Eicosapentaenoic acid and docosahexaenoic acid suppress the proliferation of vascular smooth muscle cells

1993 • 73 citations

Differential effects of dietary fish oil on myocardial prostaglandin I2 and thromboxane A2 production

1991 • 71 citations

Omega-3 polyunsaturated fatty acids augment endothelium-dependent vasorelaxation by enhanced release of EDRF and vasodilator prostaglandins.

1991 • 65 citations

Reduction in human neutrophil superoxide anion generation by n-3 polyunsaturated fatty acids: Role of cyclooxygenase products and endothelium-derived relaxing factor

1994 • 64 citations

Eicosapentaenoic acid suppressed the proliferation of vascular smooth muscle cells through modulation of various steps of growth signals

1996 • 63 citations

DOCOSAHEXAENOIC AND EICOSAPENTAENOIC ACIDS INHIBIT IN VITRO HUMAN LYMPHOCYTE-ENDOTHELIAL CELL ADHESION

1996 • 63 citations

Marine oils and cardiovascular reactivity

1994 • 60 citations

Docosahexaenoic Acid-Induced Vasorelaxation in Hypertensive Rats: Mechanisms of Action

2000 • 60 citations

Dietary fish oil reduces leukocyte/endothelium interaction following systemic administration of oxidatively modified low density lipoprotein.

1991 • 58 citations

Release of Isoprostanes by Human Pulmonary Artery in Organ Culture: A Cyclo-oxygenase and Nitric Oxide Dependent Pathway

1997 • 57 citations

Lipids and cardiac arrhythmia

1994 • 56 citations

Eicosapentaenoic and Docosahexaenoic Acids Reduce PGH Synthase 1 Expression in Bovine Aortic Endothelial Cells

1997 • 56 citations

The endothelium in acute coronary syndromes.

1998 • 53 citations

Clinical studies on the effects of n‐3 fatty acids on cells and eicosanoids in the cardiovascular system

1989 • 51 citations

Enhanced coronary vasoconstriction to oxidative stress product, 8-epi-prostaglandinF2α, in experimental hypercholesterolemia

1999 • 49 citations

In vivo formation of metabolites of prostaglandins I2 and I3 in the marmoset monkey (Callithrix jacchus) following dietary supplementation with tuna fish oil

1989 • 47 citations

Mechanisms of vasorelaxation induced by eicosapentaenoic acid (20:5n‐3) in WKY rat aorta

2000 • 44 citations

Pharmacological Effects of HMG CoA Reductase Inhibitors Other Than Lipoprotein Modulation

1999 • 44 citations

Dietary polyunsaturated fatty acid and antioxidant modulation of vascular dysfunction in the spontaneously hypertensive rat

2001 • 40 citations

Low dose of eicosapentaenoic acid inhibits the exaggerated growth of vascular smooth muscle cells from spontaneously hypertensive rats through suppression of transforming growth factor-β

1999 • 35 citations

Docosapentaenoic acid (22:5,n-3): metabolism and effect on prostacyclin production in endothelial cells

1996 • 32 citations

Acute non‐insulin‐like stimulation of rat muscle glucose metabolism by troglitazone in vitro

1997 • 32 citations

Dietary fish oil administration retards the development of hypertension and influences vascular neuroeffector function in the stroke prone spontaneously hypertensive rat (SHRSP)

1991 • 32 citations

Fish Oils Modulate Blood Pressure and Vascular Contractility in the Rat and Vascular Contractility in the Primate

1995 • 31 citations

Dietary lipid modification of myocardial eicosanoids following ischemia and reperfusion in the rat

1995 • 30 citations

Blockade by N‐3 polyunsaturated fatty acid of the Kv4.3 current stably expressed in Chinese hamster ovary cells

1999 • 30 citations

Omega-3 Fatty Acids Alter Soluble Coronary Heart Disease Patients Markers of Endothelial Function in

2009 • 29 citations

Mechanisms of enhanced production of PGI2 in cultured rat vascular smooth muscle cells enriched with eicosapentaenoic acid

1997 • 26 citations

Influence of cellular incorporation of n-3 eicosapentaenoic acid on intracellular Ca2+ concentration and membrane potential in vascular smooth muscle cells

1998 • 25 citations

Inhibitory effects of ω‐3 polyunsaturated fatty acids on receptor‐mediated non‐selective cation currents in rat A7r5 vascular smooth muscle cells

1997 • 24 citations

Thromboxane A2 and the development of hypertension in spontaneously hypertensive rats

1988 • 22 citations

Highly purified eicosapentaenoic acid attenuates tissue damage in experimental myocardial infarction.

1993 • 21 citations

Differences between in vivo and in vitro production of eicosanoids following long-term dietary fish oil supplementation in the rat

1991 • 20 citations

Dietary Fish Oil Administration Retards Blood Pressure Development and Influences Vascular Properties in the Spontaneously Hypertensive Rat (SHR) but not in the Stroke Prone-Spontaneously Hypertensive Rat (SHR-SP)

1994 • 16 citations

Identification of a Nonendothelial Cell Thromboxane-Like Constrictor Response and Its Interaction with the Renin-Angiotensin System in the Aorta of Spontaneously Hypertensive Rats

1994 • 14 citations

Eicosapentaenoic Acid Inhibits Mitogen-Induced Endothelin-1 Production and DNA Synthesis in Cultured Bovine Mesangial Cells

1998 • 14 citations

Eicosapentaenoic Acid and Docosahexaenoic Acid Inhibit DNA Synthesis through Inhibiting cdk2 Kinase in Vascular Smooth Muscle Cells

1997 • 12 citations

Fish oil supplementation attenuates free radical generation in short-term coronary occlusion-reperfusion in cholesterol-fed rabbits

1994 • 11 citations

Influence of Polyunsaturated Fatty Acids on Vasoconstrictions Induced by 8-iso-PGF<sub>2α</sub> and 8-iso-PGE<sub>2</sub>

2000 • 8 citations