Upregulation of osteoblast apoptosis by malignant plasma cells: a role in myeloma bone disease

Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation

1998 • 5,369 citations

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

1998 • 4,184 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

A clinical staging system for multiple myeloma correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival

1975 • 3,051 citations

Identification and characterization of a new member of the TNF family that induces apoptosis

1995 • 2,890 citations

The Biology of Chemokines and their Receptors

2000 • 2,416 citations

Apoptosis

2002 • 2,190 citations

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1995 • 2,028 citations

Increased bone formation in osteocalcin-deficient mice

1996 • 1,692 citations

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

1996 • 1,281 citations

Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis

1990 • 963 citations

The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand.

1996 • 894 citations

Multiple Myeloma: Increasing Evidence for a Multistep Transformation Process

1998 • 761 citations

Human bone cellsin vitro

1985 • 696 citations

A Coordinated Change in Chemokine Responsiveness Guides Plasma Cell Movements

2001 • 620 citations

Osteoblast Programmed Cell Death (Apoptosis): Modulation by Growth Factors and Cytokines

1998 • 585 citations

Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B

1996 • 582 citations

Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression

2001 • 525 citations

Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment

2001 • 419 citations

Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma

2000 • 397 citations

Production of Lymphotoxin, a Bone-Resorbing Cytokine, by Cultured Human Myeloma Cells

1987 • 386 citations

Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma

2001 • 385 citations

Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity

2002 • 309 citations

Apoptotic Role of Fas/Fas Ligand System in the Regulation of Erythropoiesis

1999 • 262 citations

Primary Myeloma Cells Growing in SCID-hu Mice: A Model for Studying the Biology and Treatment of Myeloma and Its Manifestations

1998 • 261 citations

Recruitment of new osteoblasts and osteoclasts is the earliest critical event in the pathogenesis of human multiple myeloma.

1991 • 256 citations

'Role of bone marrow stromal cells in the growth of human multiple myeloma

1991 • 223 citations

Augmented interleukin‐1 production and hla–dr expression in the synovium of rheumatoid arthritis patients

1988 • 222 citations

Syndecan-1 Is a Multifunctional Regulator of Myeloma Pathobiology: Control of Tumor Cell Survival, Growth, and Bone Cell Differentiation

1998 • 204 citations

Cell–cell contact between marrow stromal cells and myeloma cells via VCAM-1 and α4β1-integrin enhances production of osteoclast-stimulating activity

2000 • 201 citations

Abnormal bone remodelling in patients with myelomatosis and normal biochemical indices of bone resorption

1992 • 201 citations

'Role of bone marrow stromal cells in the growth of human multiple myeloma

1991 • 194 citations

Cell–cell contact between marrow stromal cells and myeloma cells via VCAM-1 and α4β1-integrin enhances production of osteoclast-stimulating activity

2000 • 178 citations

Expression of CD56/Neural Cell Adhesion Molecule Correlates with the Presence of Lytic Bone Lesions in Multiple Myeloma and Distinguishes Myeloma from Monoclonal Gammopathy of Undetermined Significance and Lymphomas with Plasmacytoid Differentiation

2002 • 171 citations

Myeloma bone disease

2001 • 167 citations

Tumor necrosis factor-α and interleukin-1β increase the Fas-mediated apoptosis of human osteoblasts

1999 • 151 citations

Constitutive Expression of Fas (Apo-1/CD95) Ligand on Multiple Myeloma Cells: A Potential Mechanism of Tumor-Induced Suppression of Immune Surveillance

1997 • 139 citations

TNF-α Increases Expression of IL-6 and ICAM-1 Genes Through Activation of NF-κB in Osteoblast-like ROS17/2.8 Cells

1998 • 126 citations

Changing responsiveness to chemokines allows medullary plasmablasts to leave lymph nodes

2001 • 122 citations

Hepatocyte Growth Factor (HGF) Induces Interleukin-11 Secretion From Osteoblasts: A Possible Role for HGF in Myeloma-Associated Osteolytic Bone Disease

1999 • 118 citations

Osteoblasts are regulated by the cellular adhesion through ICAM-1 and VCAM-1

1995 • 118 citations

Proinflammatory cytokines and chemokine production and expression by human osteoblasts isolated from patients with rheumatoid arthritis and osteoarthritis.

1999 • 108 citations

Negative regulation of erythroblast maturation by Fas-L+/TRAIL+ highly malignant plasma cells: a major pathogenetic mechanism of anemia in multiple myeloma

2002 • 105 citations

The expression of monocyte chemoattractant protein-1 and other chemokines by osteoblasts

1999 • 87 citations

Abnormal serum bone gla protein levels in multiple myeloma: Crucial role of bone formation and prognostic implications

1990 • 85 citations

Fas and Fas Ligand Interaction Is Necessary for Human Osteoblast Apoptosis

1997 • 83 citations

Comparison of Interleukin-1β Expression by In Situ Hybridization in Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma

1999 • 82 citations

Induction of apoptosis in murine clonal osteoblasts expressed by human T-cell leukemia virus type I tax by NF-κPB and TNF-α

1996 • 74 citations

Osteoblast stimulation in multiple myeloma lacking lytic bone lesions

1990 • 60 citations

Fas-L up-regulation by highly malignant myeloma plasma cells: role in the pathogenesis of anemia and disease progression

2001 • 60 citations

The critical role of interleukin-6, interleukin-1B and macrophage colony-stimulating factor in the pathogenesis of bone lesions in multiple myeloma

1992 • 50 citations

Modulation of resistance to anti-APO-1-induced apoptosis in osteosarcoma cells by cytokines

1997 • 37 citations

Breast Cancer Cells Release Factors That Induce Apoptosis in Human Bone Marrow Stromal Cells

2001 • 33 citations

Fas/Fas ligand (FasL)-deregulated apoptosis and IL-6 insensitivity in highly malignant myeloma cells

1998 • 31 citations

Production of parathyroid hormone‐related protein by cultured human myeloma cells

1994 • 26 citations

The Control of Proliferation, Survival and Apoptosis in Human Multiple Myeloma Cells in vitro

1999 • 24 citations

Tumor necrosis factor-alpha and interferon-gamma in serum of multiple myeloma patients.

1990 • 18 citations

Multiple myeloma cells and cells of the human osteoclast lineage share morphological and cell surface markers

1998 • 9 citations