Senile plaques in temporal lobe epilepsy

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

The molecular pathology of Alzheimer's disease

1991 • 2,603 citations

Observations on the brains of demented old people

1970 • 2,066 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

Excitatory amino acid neurotoxicity and neurodegenerative disease

1990 • 1,781 citations

Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy

1985 • 1,730 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

1987 • 1,316 citations

EPILEPSY AND THE TEMPORAL LOBES

1966 • 1,256 citations

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

1988 • 1,093 citations

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

1993 • 909 citations

Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing

1990 • 895 citations

The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease

1991 • 801 citations

Observations on the brains of non-demented old people

1968 • 656 citations

Amyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's Disease

1989 • 651 citations

β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1990 • 620 citations

Distribution of Alzheimer‐type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease

1992 • 617 citations

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.

1987 • 589 citations

An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.

1991 • 516 citations

Excitatory amino acids and Alzheimer's disease

1989 • 485 citations

The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome

1989 • 463 citations

A case‐control study of Alzheimer's disease in Australia

1990 • 449 citations

Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact.

1988 • 444 citations

Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor

1992 • 432 citations

Expression of β amyloid protein precursor mRNAs: Recognition of a novel alternatively spliced form and quantitation in alzheimer's disease using PCR

1990 • 426 citations

A4 amyloid protein deposition and the diagnosis of Alzheimer's disease

1988 • 367 citations

The pathological association between down syndrome and Alzheimer disease

1988 • 334 citations

Down's Syndrome and Alzheimer's disease: a review

1986 • 316 citations

Cortical senile plaques in coronary artery disease, aging and Alzheimer's disease

1990 • 263 citations

Neuronal localization of amyloid beta protein precursor mRNA in normal human brain and in Alzheimer's disease.

1987 • 222 citations

Diffuse type of senile plaques in the brains of Alzheimer-type dementia

1988 • 218 citations

Alzheimer changes in nondemented patients younger than sixty‐five: Possible early stages of Alzheimer's disease and senile dementia of Alzheimer type

1985 • 209 citations

Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex

1991 • 206 citations

Risk factors for Alzheimer's disease

1987 • 185 citations

The Seminal Role of β-Amyloid in the Pathogenesis of Alzheimer Disease

1992 • 182 citations

Large amounts of neocortical βA4 deposits without neuritic plaques nor tangles in a psychometrically assessed, non-demented person

1990 • 174 citations

Clinical risk factors for Alzheimer's disease

1991 • 168 citations

Neuropathology of status epilepticus in humans.

1983 • 166 citations

Immunocytochemical localization of the precursor protein for β-amyloid in the rat central nervous system

1988 • 153 citations

Identification of a stable fragment of the Alzheimer amyloid precursor containing the beta-protein in brain microvessels.

1992 • 141 citations

Age-related changes in the density and morphology of plaques and neurofibrillary tangles in Down syndrome brain

1989 • 125 citations

Risk Factors for Alzheimer's Disease: Overview of the EURODEM Collaborative Re-Analysis of Case-Control Studies

1991 • 125 citations

History of dementia and Parkinson's disease in 1st‐degree relatives of patients with Alzheimer's disease

1989 • 118 citations

Alzheimer beta/A4 amyloid precursor protein in human brain: aging-associated increases in holoprotein and in a proteolytic fragment.

1991 • 105 citations

Distinctive, rapid, and easy labeling of diffuse plaques in the Alzheimer brains by a new methenamine silver stain

1990 • 89 citations

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and neuritic plaque amyloid peptides

1988 • 87 citations

Modern Trends in Neurology

1971 • 87 citations

The Dementia of Down's Syndrome and its Relevance to Aetiological Studies of Alzheimer's Disease

1982 • 85 citations

THE TOPOGRAPHIC DISTRIBUTION OF SENILE PLAQUES AND NEUROFIBRILLARY TANGLES IN THE BRAINS OF NON‐DEMENTED PERSONS OF DIFFERENT AGES

1987 • 81 citations

Induction of amyloid precursor protein mRNA after heat shock in cultured human lymphoblastoid cells

1991 • 78 citations

Widespread expression of amyloid beta-protein precursor gene in rat brain.

1989 • 78 citations

Localization of the putative precursor of Alzheimer's disease-specific amyloid at nuclear envelopes of adult human muscle.

1988 • 76 citations

Effect of pre- and postmortem variables on specific mRNA levels in human brain

1991 • 74 citations

Regional accumulation of amyloid protein precursor in the gerbil brain following transient cerebral ischemia

1992 • 55 citations

Deposition of amyloid ? protein in non-Alzheimer dementias: evidence for a neuronal origin of parenchymal deposits of ? protein in neurodegenerative disease

1992 • 44 citations

The neuropathology of temporal lobe epilepsy.

1970 • 27 citations

βA4 deposition in the temporal cortex of adults with Down's syndrome

1992 • 21 citations

AMYLOID (A4) PROTEIN DEPOSITION IN BRAIN IN PROGRESSIVE SUPRANUCLEAR PALSY (PSP)

1988 • 16 citations

DEPOSITION OF AMYLOID (A4) PROTEIN IN THE CEREBRAL CORTEX IN PARKINSON??S DISEASE (PD)

1988 • 7 citations

FAMILIAL AND SPORADIC CEREBRAL AMYLOID ANGIOPATHY

1988 • 3 citations