Urokinase-type plasminogen activator and malignancy

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

The plasminogen activator/plasmin system.

1991 • 1,196 citations

Purification and characterization of the plasminogen activator secreted by human melanoma cells in culture.

1981 • 792 citations

A cellular binding site for the Mr 55,000 form of the human plasminogen activator, urokinase.

1985 • 731 citations

Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro.

1990 • 466 citations

Enhanced production and extracellular deposition of the endothelial-type plasminogen activator inhibitor in cultured human lung fibroblasts by transforming growth factor-beta.

1986 • 443 citations

Urokinase-type plasminogen activator is expressed in stromal cells and its receptor in cancer cells at invasive foci in human colon adenocarcinomas.

1991 • 440 citations

Plasminogen activator inhibitors: hormonally regulated serpins

1990 • 409 citations

Urokinase (uPA) and its inhibitor PAI-1 are strong and independent prognostic factors in node-negative breast cancer

1993 • 367 citations

Growth factors in the regulation of pericellular proteolysis: a review.

1989 • 342 citations

Plasminogen Activation Initiated by Single-chain Urokinase-type Plasminogen Activator

1989 • 341 citations

Stromal expression of 72 kda type IV collagenase (MMP-2) and TIMP-2 mRNAs in colorectal neoplasia.

1992 • 333 citations

Urokinase-plasminogen activator, a new and independent prognostic marker in breast cancer.

1990 • 294 citations

Urokinase-plasminogen activator, a marker for aggressive breast carcinomas. Preliminary report

1988 • 294 citations

In vivo invasion of modified chorioallantoic membrane by tumor cells: the role of cell surface-bound urokinase.

1988 • 273 citations

Inhibition of receptor-bound urokinase by plasminogen-activator inhibitors.

1990 • 272 citations

Transforming growth factor-beta induction of type-1 plasminogen activator inhibitor. Pericellular deposition and sensitivity to exogenous urokinase.

1987 • 263 citations

Prognostic value of urokinase-type plasminogen activator in 671 primary breast cancer patients.

1992 • 239 citations

Clinical Relevance of the Urokinase-Type and Tissue-Type Plasminogen Activators and of Their Type 1 Inhibitor in Breast Cancer

1991 • 236 citations

Hepatocyte growth factor increases urokinase-type plasminogen activator (u-PA) and u-PA receptor expression in Madin-Darby canine kidney epithelial cells.

1992 • 219 citations

The human urokinase-plasminogen activator gene and its promoter

1985 • 211 citations

Urokinase-type plasminogen activator (u-PA) antigen is a predictor of early relapse in breast cancer

1990 • 189 citations

Localization of urokinase-type plasminogen activator in stromal cells in adenocarcinomas of the colon in humans.

1991 • 179 citations

Immunocytochemical localization of urokinase-type plasminogen activator in Lewis lung carcinoma.

1984 • 173 citations

Biochemical and biological aspects of the plasminogen activation system

1990 • 165 citations

Immunological identity of urokinase and ovarian carcinoma plasminogen activator released in tissue culture

1976 • 161 citations

The role of urokinase-type plasminogen activator in aggressive tumor cell behavior

1990 • 158 citations

Age dependence of ischaemic heart syndromes and the contribution of haemostatic deviations

1992 • 146 citations

Regulation of urokinase receptors in monocytelike U937 cells by phorbol ester phorbol myristate acetate.

1989 • 142 citations

Increase of urokinase-type plasminogen activator gene expression in human lung and breast carcinomas.

1987 • 136 citations

Multiparametric Prognostic Evaluation of Biological Factors in Primary Breast Cancer

1992 • 125 citations

Role of the urokinase receptor in facilitating extracellular matrix invasion by cultured colon cancer.

1991 • 123 citations

Plasminogen activator activity and composition in human breast cancer.

1982 • 123 citations

Expression of Human Recombinant Plasminogen Activators Enhances Invasion and Experimental Metastasis of H-ras-Transformed NIH 3T3 Cells

1989 • 120 citations

Regulation of the synthesis and activity of urokinase plasminogen activator in A549 human lung carcinoma cells by transforming growth factor-beta

1988 • 118 citations

Plasminogen activator secretion of human tumors in short-term organ culture, including a comparison of primary and metastatic colon tumors.

1983 • 116 citations

IFN-gamma, tumor necrosis factor-alpha, and urokinase regulate the expression of urokinase receptors on human monocytes.

1988 • 101 citations

Type‐1 plasminogen activator inhibitor in human breast carcinomas

1992 • 100 citations

Mouse L cells expressing human prourokinase-type plasminogen activator: effects on extracellular matrix degradation and invasion.

1989 • 99 citations

Immunohistochemical evidence of urokinase-type plasminogen activator in primary and metastatic tumors of pulmonary adenocarcinoma.

1991 • 96 citations

Differential protease expression by cutaneous squamous and basal cell carcinomas.

1991 • 95 citations

Expression of human recombinant plasminogen activators enhances invasion and experimental metastasis of H-ras-transformed NIH 3T3 cells.

1989 • 95 citations

The content of urokinase‐type plasminogen activator antigen as a prognostic factor in urinary bladder cancer

1992 • 94 citations

The placental type plasminogen activator inhibitor, PAI 2

1987 • 91 citations

Examination of the role of the urokinase receptor in human colon cancer mediated laminin degradation.

1989 • 90 citations

Estradiol preferentially enhances extracellular tissue plasminogen activators of MCF-7 breast cancer cells.

1984 • 77 citations

The urokinase receptor and regulation of cell surface plasminogen activation

1990 • 75 citations

Plasminogen activator inhibitor-type 1 in Lewis lung carcinoma

1990 • 74 citations

Plasminogen activators and cancer.

1990 • 73 citations

Characterization of plasminogen activators from normal human breast and colon and from breast and colon carcinomas

1984 • 72 citations

Transcriptional and posttranscriptional activation of urokinase plasminogen activator gene expression in metastatic tumor cells.

1992 • 61 citations

Human plasma fibronectin as a substrate for human urokinase

1989 • 58 citations

Invasion of brain tissue by primary glioma: Evidence for the involvement of urokinase-type plasminogen activator as an activator of type iv collagenase

1992 • 58 citations

The control of the synthesis and secretion of plasminogen activator by rat sertoli cells in culture

1982 • 57 citations

Multiple forms of plasminogen activator in human breast tumors.

1985 • 56 citations

Endogenous receptor-bound urokinase mediates tissue invasion of the human lung carcinoma cell lines A549 and Calu-1.

1992 • 55 citations

Plasminogen receptors in the mediation of pericellular proteolysis

1990 • 55 citations

Plasmin binding to the plasminogen receptor enhances catalytic efficiency and activates the receptor for subsequent ligand binding

1991 • 49 citations

Fibrinolytic properties of single chain urokinase-type plasminogen activator (Pro-urokinase)

1990 • 49 citations

Comparative study of plasminogen activators in cancers and normal mucosae of human urinary bladder.

1989 • 49 citations

Transforming growth factor beta stimulates urokinase-type plasminogen activator and DNA synthesis, but not prostaglandin E2 production, in human synovial fibroblasts.

1991 • 47 citations

Plasminogen activator gene expression is induced by the src oncogene product and tumor promoters.

1990 • 47 citations

Immunolocalization of urokinase-type plasminogen activator in adenomas and carcinomas of the colorectum

1991 • 42 citations

Examination of the effects of epidermal growth factor on the production of urokinase and the expression of the plasminogen activator receptor in a human colon cancer cell line.

1989 • 42 citations

Plasminogen Activators in Human Malignant Melanoma<xref ref-type="fn" rid="FN2">2</xref>

1984 • 40 citations

Plasminogen activators in human colorectal neoplasia.

1986 • 39 citations

Plasminogen activators in human gastric cancers: Correlation with DNA ploidy and immunohistochemical staining

1991 • 38 citations

Urokinase-plasminogen activator in breast cancer

1991 • 34 citations

Induction of urokinase activity and malignant phenotype in bladder carcinoma cells after transfection of the activated Ha-ras oncogene

1989 • 26 citations

Urokinase‐type plasminogen activator biosynthesis is induced by the EJ‐Ha‐ras oncogene in CL26 mouse colon carcinoma cells

1989 • 24 citations

Rapid elevation of plasminogen activator activity in rat tissues by prolactin

1984 • 22 citations

Plasminogen activators in human breast cancer cell lines: Hormonal regulation and properties

1988 • 16 citations

Urokinase—the enzyme responsible for invasion and metastasis in human breast carcinoma?

1987 • 15 citations

Determination of the effects of epidermal growth factor on urokinase secretion and urokinase receptor display in a well-differentiated human colon carcinoma cell line.

1989 • 14 citations

Hormone control of total plasminogen activator activity is specific to malignant DMBA-induced rat mammary tumours

1992 • 10 citations

Deleted Work

1955 • 0 citations