Modulators of cellular protein phosphorylation alter thetrans-activation function of human progesterone receptor and the biological activity of progesterone antagonists

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.

1990 • 1,510 citations

Steroid Receptor Family: Structure and Functions

1990 • 820 citations

Dopaminergic and Ligand-Independent Activation of Steroid Hormone Receptors

1991 • 577 citations

Coupling of dual signaling pathways: epidermal growth factor action involves the estrogen receptor.

1992 • 486 citations

Endocrine Pharmacology of Antiestrogens as Antitumor Agents*

1990 • 403 citations

Regulation of Progesterone Receptor-Mediated Transcription by Phosphorylation

1990 • 365 citations

Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation.

1992 • 363 citations

Agonistic and antagonistic activities of RU486 on the functions of the human progesterone receptor.

1990 • 333 citations

Phosphorylation of Steroid Hormone Receptors*

1992 • 243 citations

Acquired Tamoxifen Resistance: Correlation With Reduced Breast Tumor Levels of Tamoxifen and Isomerization of Trans-4-Hydroxytamoxifen

1991 • 233 citations

Down-regulation and Phosphorylation of Glucocorticoid Receptors in Cultured Cells

1989 • 223 citations

Dopamine Activation of an Orphan of the Steroid Receptor Superfamily

1991 • 217 citations

The Molecular Biology of RU486. Is There a Role for Antiprogestins in the Treatment of Breast Cancer?*

1992 • 212 citations

Identification of phosphorylated sites in the mouse glucocorticoid receptor.

1991 • 208 citations

The progesterone antagonist RU486 acquires agonist activity upon stimulation of cAMP signaling pathways.

1993 • 208 citations

Adrenal Steroid Antagonism

1984 • 208 citations

Progesterone Receptor Regulation in Uterine Cells:Stimulation by Estrogen, Cyclic Adenosine 3′,5′-Monophosphate, and Insulin-Like Growth Factor I andSuppression by Antiestrogens and Protein KinaseInhibitors*

1991 • 203 citations

A Rapid, Sensitive, and Inexpensive Assay for Chloramphenicol Acetyltransferase

1987 • 196 citations

Two types of antiprogestins identified by their differential action in transcriptionally active extracts from T47D cells

1991 • 182 citations

Regulation of gene expression by the thyroid hormone receptor

1990 • 166 citations

Receptors bound to antiprogestin form abortive complexes with hormone responsive elements

1988 • 164 citations

RU 38486: An Original Multifaceted Antihormone in Vivo

1984 • 163 citations

Immunologic analysis of human breast cancer progesterone receptors. 1. Immunoaffinity purification of transformed receptors and production of monoclonal antibodies

1987 • 162 citations

Modulation of glucocorticoid receptor function by protein kinase A.

1992 • 162 citations

Human Progesterone Receptor Complexed with the Antagonist RU 486 Binds to Hormone Response Elements in a Structurally Altered Form

1989 • 138 citations

Dimerization of mammalian progesterone receptors occurs in the absence of DNA and is related to the release of the 90-kDa heat shock protein.

1991 • 133 citations

Estrogen receptor phosphorylation. Hormonal dependence and consequence on specific DNA binding.

1992 • 132 citations

Hormonal regulation and identification of chicken progesterone receptor phosphorylation sites.

1990 • 131 citations

Differential DNA-binding abilites of estrogen receptor occupied with two classes of antiestrogens: studies using human estrogen receptor overexpressed in mammalian cells

1991 • 128 citations

Phosphorylation on Tyrosine ofin VitroSynthesized Human Estrogen Receptor Activates Its Hormone Binding

1989 • 122 citations

Hormone-induced progesterone receptor phosphorylation consists of sequential DNA-independent and DNA-dependent stages: analysis with zinc finger mutants and the progesterone antagonist ZK98299.

1992 • 119 citations

Effects of hormone and cellular modulators of protein phosphorylation on transcriptional activity, DNA binding, and phosphorylation of human progesterone receptors.

1992 • 117 citations

Phosphotryptic Peptide Analysis of Human Progesterone Receptors

1989 • 95 citations

Retinoic acid receptor-beta: immunodetection and phosphorylation on tyrosine residues.

1992 • 86 citations

Ligands induce conformational changes in the carboxyl-terminus of progesterone receptors which are detected by a site-directed antipeptide monoclonal antibody.

1992 • 81 citations

A Quantitative Comparison of Dual Control of a Hormone Response Element by Progestins and Glucocorticoids in the Same Cell Line

1989 • 80 citations

Human Progesterone Receptor Binding to Mouse Mammary Tumor Virus Deoxyribonucleic Acid: Dependence on Hormone and Nonreceptor Nuclear Factor(s)

1989 • 73 citations

Human Progesterone Receptor Transformation and Nuclear Down-Regulation are Independent of Phosphorylation

1988 • 73 citations

Uterine Estrogen Receptor Interaction with Estrogen-Responsive DNA Sequencesin Vitro: Effects of Ligand Binding on Receptor-DNA Complexes

1990 • 73 citations

Uterine Estrogen Receptorin Vivo: Phosphorylation of Nuclear Specific Forms on Serine Residues

1991 • 72 citations

Ligand and DNA-dependent phosphorylation of human progesterone receptor in vitro.

1992 • 69 citations

Higher levels of control: modulation of steroid hormone-regulated gene transcription.

1992 • 67 citations

Effects of okadaic acid, a protein phosphatase inhibitor, on glucocorticoid receptor-mediated enhancement.

1992 • 64 citations

Progesterone Induction of Metallothionein-II_AGene Expression

1988 • 60 citations

Chicken progesterone receptor is phosphorylated by a DNA-dependent protein kinase during in vitro transcription assays.

1992 • 60 citations

Progesterone enhances target gene transcription by receptor free of heat shock proteins hsp90, hsp56, and hsp70.

1991 • 59 citations

Phosphorylation of steroid hormone receptors

1990 • 57 citations

Effects of the steroid antagonist RU486 on dimerization of the human progesterone receptor

1992 • 52 citations

Hormone-Dependent Regulation of Chicken Progesterone Receptor Deoxyribonucleic Acid Binding and Phosphorylation*

1989 • 49 citations

Uterine Estrogen Receptor-DNA Complexes: Effects of Different ERE Sequences, Ligands, and Receptor Forms

1991 • 46 citations

Dimerization of the Chicken Progesterone Receptorin VitroCan Occur in the Absence of Hormone and DNA

1990 • 44 citations

Cellular progesterone receptor phosphorylation in response to ligands activating protein kinases

1987 • 31 citations

Mechanisms controlling steroid receptor binding to specific DNA sequences

1991 • 25 citations