Uterine Estrogen Receptor-DNA Complexes: Effects of Different ERE Sequences, Ligands, and Receptor Forms

The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer

1988 • 1,233 citations

Nuclear receptors enhance our understanding of transcription regulation

1988 • 1,062 citations

Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen.

1990 • 772 citations

Inhibition of estrogen receptor-DNA binding by the "pure" antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerization.

1990 • 400 citations

Estrogen-responsive element of the human pS2 gene is an imperfectly palindromic sequence.

1989 • 330 citations

Activation, Transformation, and Subunit Structure of Steroid Hormone Receptors

1982 • 323 citations

Identification of two transactlvation domains in the mouse oestrogen receptor

1989 • 303 citations

Identification of an estrogen response element upstream of the human c-fosgene that binds the estrogen receptor and the AP-1 transcription factor

1990 • 296 citations

The 5′ flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA), the c-Ha-ras oncoprotein and the c-jun protein.

1989 • 260 citations

Identification of an estrogen-responsive element from the 5'-flanking region of the rat prolactin gene.

1987 • 231 citations

The progesterone receptor stimulates cell-free transcription by enhancing the formation of a stable preinitiation complex

1990 • 223 citations

Structural Determinants of a Glucocorticoid Receptor Recognition Element

1990 • 201 citations

Specific binding of estrogen receptor to the estrogen response element.

1989 • 199 citations

Steroid hormone antagonists at the receptor level: A role for the heat‐shock protein MW 90,000 (hsp 90)

1987 • 143 citations

Human estrogen receptor forms multiple protein-DNA complexes.

1990 • 126 citations

Identification of a functional intermediate in receptor activation in progesterone-dependent cell-free transcription

1990 • 110 citations

Estrogen receptor binding to a DNA response element in vitro is not dependent upon estradiol

1990 • 106 citations

Structural differences between the hormone and antihormone estrogen receptor complexes bound to the hormone response element.

1991 • 84 citations

An upstream region of the rat luteinizing hormone β gene binds estrogen receptor and confers estrogen responsiveness

1989 • 81 citations

Uterine Estrogen Receptor Interaction with Estrogen-Responsive DNA Sequencesin Vitro: Effects of Ligand Binding on Receptor-DNA Complexes

1990 • 73 citations

Modulation of the estrogen receptor's affinity for DNA by estradiol.

1985 • 73 citations

Dimerization among nuclear hormone receptors.

1990 • 71 citations

Characterization of the Subunit Nature of Nuclear Estrogen Receptors by Chemical Cross-Linking and Dense Amino Acid Labeling*

1985 • 56 citations

The human estrogen receptor has transcriptional activator and repressor functions in the absence of ligand.

1990 • 55 citations

Diethylstilbestrol Metabolites and Analogs

1989 • 50 citations

Nuclear estrogen receptor molecular heterogeneity in the mouse uterus.

1988 • 46 citations

Glucocorticoid receptor structure and the initial events in signal transduction.

1990 • 37 citations